CN101466693B - 用作人乳头瘤病毒抑制剂的哌啶衍生物 - Google Patents

用作人乳头瘤病毒抑制剂的哌啶衍生物 Download PDF

Info

Publication number
CN101466693B
CN101466693B CN2007800218616A CN200780021861A CN101466693B CN 101466693 B CN101466693 B CN 101466693B CN 2007800218616 A CN2007800218616 A CN 2007800218616A CN 200780021861 A CN200780021861 A CN 200780021861A CN 101466693 B CN101466693 B CN 101466693B
Authority
CN
China
Prior art keywords
phenyl
methyl
bromo
methoxyl group
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800218616A
Other languages
English (en)
Chinese (zh)
Other versions
CN101466693A (zh
Inventor
M·布卢门菲尔德
D·孔佩尔
J-M·戈捷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anaconda Pharma SAS
Original Assignee
Anaconda Pharma SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anaconda Pharma SAS filed Critical Anaconda Pharma SAS
Publication of CN101466693A publication Critical patent/CN101466693A/zh
Application granted granted Critical
Publication of CN101466693B publication Critical patent/CN101466693B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2007800218616A 2006-05-19 2007-05-18 用作人乳头瘤病毒抑制剂的哌啶衍生物 Expired - Fee Related CN101466693B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0604496A FR2901273B1 (fr) 2006-05-19 2006-05-19 Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant
FR0604496 2006-05-19
PCT/EP2007/054843 WO2007135106A1 (fr) 2006-05-19 2007-05-18 Derives de piperidine comme inhibiteurs du virus du papillome humain

Publications (2)

Publication Number Publication Date
CN101466693A CN101466693A (zh) 2009-06-24
CN101466693B true CN101466693B (zh) 2012-12-12

Family

ID=37575135

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800218616A Expired - Fee Related CN101466693B (zh) 2006-05-19 2007-05-18 用作人乳头瘤病毒抑制剂的哌啶衍生物

Country Status (13)

Country Link
US (3) US8207373B2 (enExample)
EP (1) EP2024350B1 (enExample)
JP (1) JP5399237B2 (enExample)
CN (1) CN101466693B (enExample)
AR (1) AR061027A1 (enExample)
BR (1) BRPI0711208A2 (enExample)
CA (1) CA2652469C (enExample)
DK (1) DK2024350T3 (enExample)
ES (1) ES2436772T3 (enExample)
FR (1) FR2901273B1 (enExample)
MX (1) MX2008014771A (enExample)
PT (1) PT2024350E (enExample)
WO (1) WO2007135106A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2923825B1 (fr) * 2007-11-20 2013-05-03 Anaconda Pharma Nouveaux inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant.
FR2990134B1 (fr) * 2012-05-07 2014-11-21 Anaconda Pharma Composition pharmaceutique d'un inhibiteur du virus du papillome
FR3000490B1 (fr) 2012-12-27 2015-03-13 Anaconda Pharma Procede de synthese d'une hydrazine utile dans le traitement du virus du papillome
ES2796276T3 (es) * 2015-02-05 2020-11-26 Ab Science Compuestos con actividad antitumoral
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives
CN105582083A (zh) * 2015-09-08 2016-05-18 石友爱 一种治疗鲍温样丘疹病的中药
CN108530310B (zh) * 2017-03-02 2025-01-28 中国科学院上海药物研究所 2-(取代苯杂基)芳香甲酸类fto抑制剂，其制备方法及其应用
CN109748903B (zh) * 2017-11-01 2021-08-10 北京协和制药二厂 吡法齐明的制备方法
EP3594206A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-quinoline derivatives for treating a rna virus infection
EP3594205A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
JP2020127293A (ja) * 2019-02-05 2020-08-20 ファナック株式会社 ロータコアの製造装置及びロータコアの製造方法、並びにロータ構造
CN110041223B (zh) * 2019-06-03 2021-10-22 西北师范大学 以肼类化合物为原料氧化合成偶氮类化合物的方法
EP3999493B1 (en) 2019-07-19 2023-12-20 Abivax Aryl-n-aryl derivatives for treating a rna virus infection
CN114276273B (zh) * 2021-12-29 2024-06-21 维思普新材料（苏州）有限公司 一种基于四苯基肼类衍生物的有机电致发光材料及其电子器件

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1347318A (zh) * 1999-03-19 2002-05-01 沃泰克斯药物股份有限公司 Impdh酶抑制剂
WO2004108673A2 (en) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292429A (en) * 1978-03-08 1981-09-29 Ciba-Geigy Corporation Imidazole urea and amido compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1347318A (zh) * 1999-03-19 2002-05-01 沃泰克斯药物股份有限公司 Impdh酶抑制剂
WO2004108673A2 (en) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus

Also Published As

Publication number Publication date
DK2024350T3 (da) 2013-12-09
FR2901273B1 (fr) 2010-12-24
CA2652469C (fr) 2016-05-03
EP2024350B1 (fr) 2013-09-18
US8207373B2 (en) 2012-06-26
US20170079968A1 (en) 2017-03-23
JP5399237B2 (ja) 2014-01-29
MX2008014771A (es) 2008-11-28
US9974779B2 (en) 2018-05-22
US20180021318A9 (en) 2018-01-25
US20090209586A1 (en) 2009-08-20
US20120220633A1 (en) 2012-08-30
US9452991B2 (en) 2016-09-27
WO2007135106A1 (fr) 2007-11-29
JP2009537595A (ja) 2009-10-29
BRPI0711208A2 (pt) 2011-03-22
PT2024350E (pt) 2013-12-11
EP2024350A1 (fr) 2009-02-18
ES2436772T3 (es) 2014-01-07
CA2652469A1 (fr) 2007-11-29
AR061027A1 (es) 2008-07-30
FR2901273A1 (fr) 2007-11-23
CN101466693A (zh) 2009-06-24

Similar Documents

Publication Publication Date Title
CN101466693A (zh) 用作人乳头瘤病毒抑制剂的哌啶衍生物
EP0570594B1 (en) Hydroxamic acid derivative based on aromatic sulfonamide
CN114174283B (zh) 作为nmt抑制剂的化合物及其应用
CA2682393A1 (en) 5-membered heterocyclic derivative and use thereof for medical purposes
CN110041327A (zh) 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN103086935B (zh) 二苯硒醚、二苯硒亚砜、二苯硒砜类化合物及其用途
WO2008054454A2 (en) Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents
CN108033952B (zh) 含有三唑环的苯丙氨酸衍生物及其制备方法与应用
US20100240660A1 (en) New histone deacetylases inhibitors
WO2008107320A1 (fr) Derives de piperidine et de piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
CN112390781B (zh) 二芳基取代的1,1-乙烯类化合物、制备方法及用途
WO2021188949A1 (en) 3-diarylmethylenes and uses thereof
JP5547082B2 (ja) 新規なヒトパピローマウイルス阻害剤およびそれを含有する医薬組成物
WO1998052919A1 (en) Phthalimide derivatives and pharmaceutical containing said derivatives
CN109796418B (zh) 含有4-苯基-1,2,3-三氮唑的苯丙氨酸衍生物及其制备方法与应用
CN101070300B (zh) 柠檬烯类似物及其制备方法和用途
CN115677703A (zh) 吡啶酮类化合物及其用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121212

Termination date: 20180518