CA2632078C - Methods of inducing terminal differentiation - Google Patents

Methods of inducing terminal differentiation Download PDF

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Publication number
CA2632078C
CA2632078C CA 2632078 CA2632078A CA2632078C CA 2632078 C CA2632078 C CA 2632078C CA 2632078 CA2632078 CA 2632078 CA 2632078 A CA2632078 A CA 2632078A CA 2632078 C CA2632078 C CA 2632078C
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Prior art keywords
saha
ray diffraction
degrees
crystalline
theta
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Expired - Lifetime
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CA 2632078
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English (en)
French (fr)
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CA2632078A1 (en
Inventor
Thomas A. Miller
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Merck HDAC Research LLC
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Merck HDAC Research LLC
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Application filed by Merck HDAC Research LLC filed Critical Merck HDAC Research LLC
Publication of CA2632078A1 publication Critical patent/CA2632078A1/en
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Publication of CA2632078C publication Critical patent/CA2632078C/en
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    • AHUMAN NECESSITIES
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    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
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    • A61K31/13Amines
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/164Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
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    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
CA 2632078 2002-03-04 2003-03-04 Methods of inducing terminal differentiation Expired - Lifetime CA2632078C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36175902P 2002-03-04 2002-03-04
US60/361,759 2002-03-04
CA 2478094 CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA 2478094 Division CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Publications (2)

Publication Number Publication Date
CA2632078A1 CA2632078A1 (en) 2003-09-18
CA2632078C true CA2632078C (en) 2012-08-14

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Family Applications (3)

Application Number Title Priority Date Filing Date
CA 2632078 Expired - Lifetime CA2632078C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation
CA 2478094 Expired - Lifetime CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation
CA2671976A Expired - Lifetime CA2671976C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

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Application Number Title Priority Date Filing Date
CA 2478094 Expired - Lifetime CA2478094C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation
CA2671976A Expired - Lifetime CA2671976C (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Country Status (18)

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US (7) US20040072735A1 (US20040072735A1-20040415-C00060.png)
EP (4) EP1487426B1 (US20040072735A1-20040415-C00060.png)
JP (4) JP4732693B2 (US20040072735A1-20040415-C00060.png)
KR (2) KR100892016B1 (US20040072735A1-20040415-C00060.png)
CN (3) CN103393630A (US20040072735A1-20040415-C00060.png)
AU (1) AU2003213684C1 (US20040072735A1-20040415-C00060.png)
BR (1) BR0308250A (US20040072735A1-20040415-C00060.png)
CA (3) CA2632078C (US20040072735A1-20040415-C00060.png)
ES (1) ES2532607T3 (US20040072735A1-20040415-C00060.png)
HK (1) HK1072362A1 (US20040072735A1-20040415-C00060.png)
IL (3) IL163909A0 (US20040072735A1-20040415-C00060.png)
MX (1) MXPA04008577A (US20040072735A1-20040415-C00060.png)
NO (2) NO329984B1 (US20040072735A1-20040415-C00060.png)
NZ (3) NZ550185A (US20040072735A1-20040415-C00060.png)
PL (1) PL372239A1 (US20040072735A1-20040415-C00060.png)
RU (3) RU2394022C2 (US20040072735A1-20040415-C00060.png)
WO (1) WO2003075839A2 (US20040072735A1-20040415-C00060.png)
ZA (2) ZA200407942B (US20040072735A1-20040415-C00060.png)

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