CA2619817A1 - Thermodynamically stable polymorph of an azabicyclohexane - Google Patents

Thermodynamically stable polymorph of an azabicyclohexane Download PDF

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Publication number
CA2619817A1
CA2619817A1 CA002619817A CA2619817A CA2619817A1 CA 2619817 A1 CA2619817 A1 CA 2619817A1 CA 002619817 A CA002619817 A CA 002619817A CA 2619817 A CA2619817 A CA 2619817A CA 2619817 A1 CA2619817 A1 CA 2619817A1
Authority
CA
Canada
Prior art keywords
polymorph
polymorph form
acid addition
azabicyclo
hexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002619817A
Other languages
English (en)
French (fr)
Inventor
Eric J. Hagen
Kevin Halloran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOV Pharmaceutical Inc
Original Assignee
Euthymics Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euthymics Bioscience Inc filed Critical Euthymics Bioscience Inc
Publication of CA2619817A1 publication Critical patent/CA2619817A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CA002619817A 2004-08-18 2005-08-17 Thermodynamically stable polymorph of an azabicyclohexane Abandoned CA2619817A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
US10/920,748 2004-08-18
PCT/US2005/029420 WO2006023659A2 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Publications (1)

Publication Number Publication Date
CA2619817A1 true CA2619817A1 (en) 2006-03-02

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002619817A Abandoned CA2619817A1 (en) 2004-08-18 2005-08-17 Thermodynamically stable polymorph of an azabicyclohexane

Country Status (14)

Country Link
EP (1) EP1786417A4 (ja)
JP (1) JP2008510715A (ja)
KR (3) KR20130108489A (ja)
CN (1) CN101052393A (ja)
AU (1) AU2005277351A1 (ja)
BR (1) BRPI0515193A (ja)
CA (1) CA2619817A1 (ja)
IL (1) IL181185A (ja)
MX (1) MX2007001827A (ja)
NO (1) NO20071372L (ja)
NZ (1) NZ589033A (ja)
RU (1) RU2007109817A (ja)
WO (1) WO2006023659A2 (ja)
ZA (1) ZA200701570B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
BRPI0613943B1 (pt) 2005-07-27 2021-06-22 Otsuka America Pharmaceutical, Inc Composto, composição farmacêutica o compreendendo, usos de um composto e de uma composição farmacêutica, bem como composição neurobiologicamente ativa
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
JP2013544850A (ja) * 2010-12-03 2013-12-19 ユーシミクス バイオサイエンス，インク． モノアミン神経伝達物質によって影響を受ける病態の処置における（＋）−１−（３，４−ジクロロフェニル）−３−アザビシクロ［３．１．０］ヘキサンの調製および使用
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
EP2994129A4 (en) * 2013-05-07 2017-01-25 Euthymic Bioscience, Inc. Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive and alcohol-related disorders
KR101567003B1 (ko) 2013-12-27 2015-11-06 경희대학교 산학협력단 골편 고정장치 및 골편 절단을 위한 드릴 어셈블리
CA2989431C (en) 2015-06-17 2023-08-29 Franklin Bymaster Crystalline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Also Published As

Publication number Publication date
CN101052393A (zh) 2007-10-10
NZ589033A (en) 2012-06-29
JP2008510715A (ja) 2008-04-10
IL181185A (en) 2012-10-31
ZA200701570B (en) 2008-08-27
WO2006023659A3 (en) 2006-12-07
AU2005277351A1 (en) 2006-03-02
EP1786417A4 (en) 2009-05-20
KR20130108489A (ko) 2013-10-02
WO2006023659A2 (en) 2006-03-02
RU2007109817A (ru) 2008-09-27
NO20071372L (no) 2007-05-18
MX2007001827A (es) 2007-04-23
KR20130004370A (ko) 2013-01-09
EP1786417A2 (en) 2007-05-23
IL181185A0 (en) 2007-07-04
KR20070054208A (ko) 2007-05-28
BRPI0515193A (pt) 2008-07-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20180817