CA2613187A1 - Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody - Google Patents
Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody Download PDFInfo
- Publication number
- CA2613187A1 CA2613187A1 CA002613187A CA2613187A CA2613187A1 CA 2613187 A1 CA2613187 A1 CA 2613187A1 CA 002613187 A CA002613187 A CA 002613187A CA 2613187 A CA2613187 A CA 2613187A CA 2613187 A1 CA2613187 A1 CA 2613187A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- therapeutic antibody
- target antigen
- sample
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05014618.2 | 2005-07-06 | ||
| EP05014618 | 2005-07-06 | ||
| EP06004447 | 2006-03-06 | ||
| EP06004447.6 | 2006-03-06 | ||
| PCT/EP2006/006524 WO2007003420A1 (en) | 2005-07-06 | 2006-07-05 | Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2613187A1 true CA2613187A1 (en) | 2007-01-11 |
Family
ID=36922121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002613187A Abandoned CA2613187A1 (en) | 2005-07-06 | 2006-07-05 | Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070009976A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2194380A3 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008545145A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20080016939A (cg-RX-API-DMAC7.html) |
| AR (1) | AR053948A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006265275A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0612591A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2613187A1 (cg-RX-API-DMAC7.html) |
| CR (1) | CR9635A (cg-RX-API-DMAC7.html) |
| EC (1) | ECSP088081A (cg-RX-API-DMAC7.html) |
| IL (1) | IL188317A0 (cg-RX-API-DMAC7.html) |
| MA (1) | MA29730B1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008000277A (cg-RX-API-DMAC7.html) |
| MY (1) | MY157955A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20076662L (cg-RX-API-DMAC7.html) |
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Families Citing this family (23)
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| AU2001264696B2 (en) | 2000-05-19 | 2007-01-04 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an ErbB antagonist cancer therapy |
| ZA200701234B (en) * | 2004-07-22 | 2008-12-31 | Genentech Inc | HER2 antibody composition |
| US7936392B2 (en) | 2004-10-01 | 2011-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging arrangements and methods therefor |
| WO2007092545A2 (en) | 2006-02-07 | 2007-08-16 | The Board Of Trustees Of The Leland Stanford Junior University | Variable imaging arrangements and methods therefor |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CA2596133C (en) | 2005-02-23 | 2016-11-15 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| US8358354B2 (en) | 2009-01-26 | 2013-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Correction of optical abberations |
| CA2677108A1 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her inhibitor |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| PT4403228T (pt) | 2011-10-14 | 2025-10-07 | Hoffmann La Roche | Utilizações do inibidor da dimerização de her2 pertuzumab e artigo de fabrico que inclui o mesmo |
| KR101327542B1 (ko) * | 2012-03-15 | 2013-11-08 | 광주과학기술원 | 양자점 기반의 경쟁 면역분석법 및 다중 유세포 분석법을 이용한 시료 중 오염물질의 검출 방법 |
| AU2012232949B2 (en) * | 2012-09-28 | 2014-07-03 | Willowtree Holdings Pty Ltd | Temporary bulkhead |
| US9815904B2 (en) | 2013-04-16 | 2017-11-14 | Genetech, Inc. | Pertuzumab variants and evaluation thereof |
| KR20160141857A (ko) | 2014-04-25 | 2016-12-09 | 제넨테크, 인크. | 트라스투주맙-mcc-dm1 및 퍼투주맙을 이용하는 초기 유방암의 치료방법 |
| PT3302551T (pt) | 2015-05-30 | 2024-08-21 | H Hoffnabb La Roche Ag | Métodos de tratamento do cancro da mama metastático positivo para her2 não tratado previamente |
| WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| US20180221481A1 (en) | 2016-12-28 | 2018-08-09 | Genentech, Inc. | Treatment of advanced her2 expressing cancer |
| LT3570884T (lt) | 2017-01-17 | 2020-12-10 | Genentech, Inc. | Poodinės her2 antikūnų kompozicijos |
| JP6992081B2 (ja) | 2017-03-02 | 2022-02-03 | ジェネンテック， インコーポレイテッド | Ｈｅｒ２陽性乳癌のアジュバント治療 |
| WO2018200505A1 (en) | 2017-04-24 | 2018-11-01 | Genentech, Inc. | Erbb2/her2 mutations in the transmbrane or juxtamembrane domain |
| MX2022015884A (es) | 2020-06-29 | 2023-04-03 | Genentech Inc | Combinacion de dosis fija de pertuzumab mas trastuzumab. |
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|---|---|---|---|---|
| GB2095818B (en) | 1981-03-27 | 1985-10-02 | Exxon Research Engineering Co | Staged adsorption/resorption heat pump |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| CA2103059C (en) * | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
| CN101412758A (zh) | 1996-10-18 | 2009-04-22 | 基因技术股份有限公司 | 抗ErbB2抗体 |
| JP4424987B2 (ja) | 2001-09-20 | 2010-03-03 | ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム | Ｅｌｉｓａアッセイを用いた循環する治療抗体、抗原および抗原／抗体複合体の測定 |
| AU2003273218C1 (en) * | 2002-07-15 | 2019-01-17 | F. Hoffmann - La Roche Ag | Methods for identifying tumors that are responsive to treatment with anti-ErbB2 antibodies |
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- 2006-07-05 EP EP10157725A patent/EP2194380A3/en not_active Withdrawn
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- 2007-12-28 NO NO20076662A patent/NO20076662L/no not_active Application Discontinuation
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2008
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- 2008-02-01 MA MA30617A patent/MA29730B1/fr unknown
Also Published As
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| EP1902315A1 (en) | 2008-03-26 |
| AR053948A1 (es) | 2007-05-23 |
| MX2008000277A (es) | 2008-03-24 |
| KR20080016939A (ko) | 2008-02-22 |
| CR9635A (es) | 2008-02-20 |
| MY157955A (en) | 2016-08-30 |
| NZ564471A (en) | 2010-04-30 |
| US20070009976A1 (en) | 2007-01-11 |
| ECSP088081A (es) | 2008-02-20 |
| NO20076662L (no) | 2008-04-03 |
| AU2006265275A1 (en) | 2007-01-11 |
| JP2008545145A (ja) | 2008-12-11 |
| MA29730B1 (fr) | 2008-09-01 |
| EP2194380A3 (en) | 2010-07-14 |
| BRPI0612591A2 (pt) | 2010-11-23 |
| EP2194380A2 (en) | 2010-06-09 |
| TW200741203A (en) | 2007-11-01 |
| WO2007003420A1 (en) | 2007-01-11 |
| IL188317A0 (en) | 2008-04-13 |
| RU2008103608A (ru) | 2009-08-20 |
| TWI312864B (en) | 2009-08-01 |
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