CA2574060C - Immune modulating compounds from fungi - Google Patents

Immune modulating compounds from fungi Download PDF

Info

Publication number
CA2574060C
CA2574060C CA2574060A CA2574060A CA2574060C CA 2574060 C CA2574060 C CA 2574060C CA 2574060 A CA2574060 A CA 2574060A CA 2574060 A CA2574060 A CA 2574060A CA 2574060 C CA2574060 C CA 2574060C
Authority
CA
Canada
Prior art keywords
composition
polysaccharides
composition according
molecular weight
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2574060A
Other languages
English (en)
French (fr)
Other versions
CA2574060A1 (en
Inventor
Bjoern Kristiansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycanova As
Original Assignee
Glycanova As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/892,393 external-priority patent/US7514085B2/en
Application filed by Glycanova As filed Critical Glycanova As
Publication of CA2574060A1 publication Critical patent/CA2574060A1/en
Application granted granted Critical
Publication of CA2574060C publication Critical patent/CA2574060C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/071—Agaricus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2574060A 2004-07-16 2005-07-15 Immune modulating compounds from fungi Expired - Lifetime CA2574060C (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US10/892,393 US7514085B2 (en) 2004-07-16 2004-07-16 Immune modulating compounds from fungi
US10/892,393 2004-07-16
US69048205P 2005-06-15 2005-06-15
US69047705P 2005-06-15 2005-06-15
US69049605P 2005-06-15 2005-06-15
DKPA200500880 2005-06-15
US60/690,482 2005-06-15
US60/690,477 2005-06-15
DKPA200500881 2005-06-15
DKPA200500880 2005-06-15
DKPA200500881 2005-06-15
DKPA200500882 2005-06-15
US60/690,496 2005-06-15
DKPA200500882 2005-06-15
PCT/DK2005/000498 WO2006007848A2 (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi

Publications (2)

Publication Number Publication Date
CA2574060A1 CA2574060A1 (en) 2006-01-26
CA2574060C true CA2574060C (en) 2019-06-25

Family

ID=35414957

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2574060A Expired - Lifetime CA2574060C (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi

Country Status (8)

Country Link
EP (1) EP1774012A2 (enExample)
JP (3) JP2008525311A (enExample)
KR (1) KR20070057803A (enExample)
AU (1) AU2005263329A1 (enExample)
CA (1) CA2574060C (enExample)
IL (1) IL180713A0 (enExample)
TW (1) TW200607863A (enExample)
WO (1) WO2006007848A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20014256D0 (no) 2001-09-03 2001-09-03 Bjoern Kristiansen Fremstilling av immunstimulerende forbindelse
US7514085B2 (en) 2004-07-16 2009-04-07 Medimush A/S Immune modulating compounds from fungi
EP1896600A2 (en) 2005-06-15 2008-03-12 Medimush A/S Anti-cancer combination treatment and kit-of-part
WO2006133708A1 (en) * 2005-06-15 2006-12-21 Medimush A/S Bioactive agents produced by submerged cultivation of a basidiomycete cell
KR100825119B1 (ko) * 2006-12-29 2008-04-25 영남대학교 산학협력단 간질환의 예방 또는 치료용 약학조성물
WO2010130036A1 (en) * 2009-05-15 2010-11-18 Her Majesty The Queen In Right Of The Province Of Nova Scotia, As Represented By The Nova Scotia Agricultural College (Nsac) On Behalf Of The Minister Of Agriculture Stable functional beverage compositions and processes for making same
WO2015083982A1 (ko) * 2013-12-06 2015-06-11 한명순 설사 예방 및 개선용 조성물 및 이를 이용한 경구용 주사기 패키지
KR101695488B1 (ko) * 2013-12-06 2017-01-23 한명순 설사 예방 및 개선용 조성물 및 이를 이용한 경구용 주사기 패키지
CN107613997A (zh) 2015-01-18 2018-01-19 加维什-加利里生物应用有限公司 食用真菌的富含维生素d的提取物、和其组合物、和它们在治疗免疫相关失调中的应用
WO2017201615A1 (en) * 2016-05-23 2017-11-30 Orphaderm Limited Biophotonic compositions comprising a fungal-derived chromophore
KR20180093725A (ko) 2017-02-14 2018-08-22 강원대학교산학협력단 렌티난을 함유하는 패혈증의 치료 또는 개선용 약학적 조성물
CN108410944A (zh) * 2018-06-05 2018-08-17 郑州安图生物工程股份有限公司 一种检测艰难梭菌用培养基及其制备方法
TWI673058B (zh) * 2018-07-20 2019-10-01 金穎生物科技股份有限公司 靈芝複合多醣體組成物
CN110403962A (zh) * 2019-09-04 2019-11-05 湖南宇山玉月农业科技有限公司 一种真菌植物在防治鸡坏死性肠炎的应用
CN110656053B (zh) * 2019-11-01 2021-04-13 广东省微生物研究所（广东省微生物分析检测中心） 一种鳞伞属新菌种及其人工栽培方法和用途
FI130808B1 (en) * 2021-02-19 2024-03-27 Natural Resources Inst Finland Luke Fungi-derived composition, its production process and uses
IT202100029000A1 (it) 2021-11-16 2023-05-16 C I A M S R L Composizioni immunostimolanti per animali da compagnia
EP4486448A1 (en) 2022-03-04 2025-01-08 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
CN118267401B (zh) * 2024-03-28 2024-10-18 吉林农业大学 一种银耳蒂头多糖粪菌物及其在结肠炎中的应用
CN118325993B (zh) * 2024-04-16 2024-11-15 吉林农业大学 一种姬松茸活性肽及其制备方法和应用
CN118546801B (zh) * 2024-07-26 2024-10-01 烟台欣和企业食品有限公司 一株布拉迪酵母菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1572074A (en) * 1977-03-30 1980-07-23 Kirin Seagram Ltd Chemotherapeutic substances and methods of manufacturing same
JPS54148702A (en) * 1978-05-12 1979-11-21 Kirin Brewery Kss22b
JPS5653101A (en) * 1979-09-21 1981-05-12 Kirin Brewery Co Ltd Polysaccharide ks-2-d and its preparation
JPH0757761B2 (ja) * 1984-03-08 1995-06-21 株式会社林原生物化学研究所 β−グルカンとその製造方法及び用途
EP0292601A1 (en) * 1987-05-14 1988-11-30 Noda Shokukin Kogyo Co., Ltd. Anti aids drug extracted from lentinus edodes
FR2631829B1 (fr) * 1988-05-30 1992-04-03 Pasteur Institut Exopolysaccharides fongiques ayant une activite immunostimulante, leur procede d'obtention et composition therapeutique les contenant
JPH0725802B2 (ja) * 1988-11-28 1995-03-22 味の素株式会社 カードランまたはレンチナンの硫酸エステルまたはその塩の製造方法
JP3522772B2 (ja) * 1991-05-21 2004-04-26 台糖株式会社 ワクチンの免疫効果増強剤
JP3651697B2 (ja) * 1995-03-24 2005-05-25 株式会社アミノアップ化学 新規多糖体物質
CN1069650C (zh) * 1995-12-29 2001-08-15 中国科学院上海药物研究所 香菇多糖的分离纯化方法
AU6261999A (en) * 1998-09-25 2000-04-17 Collaborative Group, Ltd., The Very high molecular weight beta-glucans
NO20014256D0 (no) * 2001-09-03 2001-09-03 Bjoern Kristiansen Fremstilling av immunstimulerende forbindelse
US8173177B2 (en) * 2003-09-08 2012-05-08 Genyous Biomed International Inc. Compositions of botanical extracts for cancer therapy

Also Published As

Publication number Publication date
IL180713A0 (en) 2007-06-03
JP2012017347A (ja) 2012-01-26
JP2014005307A (ja) 2014-01-16
AU2005263329A1 (en) 2006-01-26
TW200607863A (en) 2006-03-01
JP5926226B2 (ja) 2016-05-25
EP1774012A2 (en) 2007-04-18
KR20070057803A (ko) 2007-06-07
JP2008525311A (ja) 2008-07-17
CA2574060A1 (en) 2006-01-26
JP5502830B2 (ja) 2014-05-28
WO2006007848A3 (en) 2006-02-23
WO2006007848A2 (en) 2006-01-26

Similar Documents

Publication Publication Date Title
US7682615B2 (en) Immune modulating compounds from fungi
CA2574060C (en) Immune modulating compounds from fungi
US20100086647A1 (en) Feed or food products comprising fungal material
TWI689585B (zh) 新穎乳酸菌株及包含新穎乳酸菌株之免疫賦活劑
KR100945587B1 (ko) 동충하초 균사체로 발효시켜 다양한 생리활성을 갖는 진세노사이드 대사체를 다량 함유하는 발효인삼 또는 발효홍삼의 제조방법
TW201021816A (en) Composition comprising a combination of an elder extract and a strain of L. paracasei, L. casei, L. bulgaricus or S. thermophilus
US20090005340A1 (en) Bioactive Agents Produced By Submerged Cultivation of a Basidiomycete Cell
US11191793B2 (en) Ganoderma lucidum polysaccharides composite composition
JP2005220065A (ja) 免疫賦活剤
TW201919657A (zh) 提昇免疫之組合物及方法
JP4499979B2 (ja) 病原菌感染抑制用組成物
KR100773059B1 (ko) 배당체 가수분해능을 가진 신규한 미생물, 이를 함유한 프로바이오틱스 및 이의 제조방법
KR20120019311A (ko) 면역기능을 증진시키기 위하여 조제한 인삼의 상황버섯 균사체 발효물로부터 분리된 다당류를 유효성분으로 포함하는 면역활성용 조성물
CN1536069B (zh) 大规模生产虫草菌和灵芝菌的方法
US20060178340A1 (en) Composition comprising soluble glucan oligomer from saccharomyces cerevisiae is2 for immune activation or prevention and treatment of cancer and the preparation method thereof
KR20180042936A (ko) 치마버섯 분리 균사체 배양액을 유효성분으로 함유하는 숙취해소 및 간질환의 예방 및 치료용 약학조성물
JP6842014B2 (ja) トロンボスポンジン１遺伝子発現亢進用組成物
KR20200092951A (ko) I형 알레르기용 조성물
KR102176839B1 (ko) 녹용 및 가시오갈피의 추출물을 포함하는 면역 증강용 조성물 및 그 제조방법
KR102025115B1 (ko) 면역력 개선 및 바이러스 질환 예방 효과를 지닌 유산균 발효액
KR102893878B1 (ko) 더위지기 추출물을 포함하는 면역증강용 조성물
CN110835378A (zh) 灵芝及酵母β-葡聚糖复合多糖体组合物
KR100593533B1 (ko) 펠리누스 질부스 균사체 추출물을 함유하는 면역 활성증강용 조성물
JP2016098191A (ja) 抗アレルギー剤

Legal Events

Date Code Title Description
EEER Examination request