WO2006007848A3 - Immune modulating compounds from fungi - Google Patents

Immune modulating compounds from fungi Download PDF

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Publication number
WO2006007848A3
WO2006007848A3 PCT/DK2005/000498 DK2005000498W WO2006007848A3 WO 2006007848 A3 WO2006007848 A3 WO 2006007848A3 DK 2005000498 W DK2005000498 W DK 2005000498W WO 2006007848 A3 WO2006007848 A3 WO 2006007848A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
fungi
immune modulating
modulating compounds
immune
Prior art date
Application number
PCT/DK2005/000498
Other languages
French (fr)
Other versions
WO2006007848A2 (en
Inventor
Bjoern Kristiansen
Original Assignee
Medimush As
Bjoern Kristiansen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/892,393 external-priority patent/US7514085B2/en
Priority to AU2005263329A priority Critical patent/AU2005263329A1/en
Priority to CN200580030988.5A priority patent/CN101018869B/en
Priority to EP05758000A priority patent/EP1774012A2/en
Priority to JP2007520666A priority patent/JP2008525311A/en
Priority to CA2574060A priority patent/CA2574060C/en
Application filed by Medimush As, Bjoern Kristiansen filed Critical Medimush As
Publication of WO2006007848A2 publication Critical patent/WO2006007848A2/en
Publication of WO2006007848A3 publication Critical patent/WO2006007848A3/en
Priority to US11/914,318 priority patent/US20100086647A1/en
Priority to MX2007014219A priority patent/MX2007014219A/en
Priority to EP06722942A priority patent/EP1885866A1/en
Priority to PCT/DK2006/000253 priority patent/WO2006119774A1/en
Priority to IL180713A priority patent/IL180713A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to compositions comprising polypeptides and polysaccharides. The compositions are in general immune modulating. The invention also discloses methods of producing these compositions using filamentous fungi cultivated in liquid medium. The compositions are useful for example in the treatment of immune compromised conditions.
PCT/DK2005/000498 2004-07-16 2005-07-15 Immune modulating compounds from fungi WO2006007848A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2005263329A AU2005263329A1 (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi
CN200580030988.5A CN101018869B (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi
EP05758000A EP1774012A2 (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi
JP2007520666A JP2008525311A (en) 2004-07-16 2005-07-15 Immunomodulatory compounds derived from fungi
CA2574060A CA2574060C (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi
US11/914,318 US20100086647A1 (en) 2005-05-13 2006-05-11 Feed or food products comprising fungal material
PCT/DK2006/000253 WO2006119774A1 (en) 2005-05-13 2006-05-11 Feed or food products comprising fungal material
EP06722942A EP1885866A1 (en) 2005-05-13 2006-05-11 Feed or food products comprising fungal material
MX2007014219A MX2007014219A (en) 2005-05-13 2006-05-11 Feed or food products comprising fungal material.
IL180713A IL180713A0 (en) 2004-07-16 2007-01-15 Immune modulating compounds from fungi

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US10/892,393 US7514085B2 (en) 2004-07-16 2004-07-16 Immune modulating compounds from fungi
US10/892,393 2004-07-16
US69048205P 2005-06-15 2005-06-15
US69047705P 2005-06-15 2005-06-15
US69049605P 2005-06-15 2005-06-15
DKPA200500880 2005-06-15
DKPA200500882 2005-06-15
US60/690,496 2005-06-15
US60/690,482 2005-06-15
DKPA200500880 2005-06-15
DKPA200500881 2005-06-15
DKPA200500882 2005-06-15
US60/690,477 2005-06-15
DKPA200500881 2005-06-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/914,318 Continuation-In-Part US20100086647A1 (en) 2005-05-13 2006-05-11 Feed or food products comprising fungal material

Publications (2)

Publication Number Publication Date
WO2006007848A2 WO2006007848A2 (en) 2006-01-26
WO2006007848A3 true WO2006007848A3 (en) 2006-02-23

Family

ID=35414957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2005/000498 WO2006007848A2 (en) 2004-07-16 2005-07-15 Immune modulating compounds from fungi

Country Status (8)

Country Link
EP (1) EP1774012A2 (en)
JP (3) JP2008525311A (en)
KR (1) KR20070057803A (en)
AU (1) AU2005263329A1 (en)
CA (1) CA2574060C (en)
IL (1) IL180713A0 (en)
TW (1) TW200607863A (en)
WO (1) WO2006007848A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249438B2 (en) 2001-09-03 2016-02-02 Glycanova As Production of fungal extracellular immune stimulating compounds

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133707A2 (en) * 2005-06-15 2006-12-21 Medimush A/S Anti-cancer combination treatment and kit-of-part
US20090005340A1 (en) * 2005-06-15 2009-01-01 Medimush A/S Bioactive Agents Produced By Submerged Cultivation of a Basidiomycete Cell
KR100825119B1 (en) * 2006-12-29 2008-04-25 영남대학교 산학협력단 Pharmaceutical composition for preventing and treating liver disease
CA2799569A1 (en) * 2009-05-15 2010-11-18 Her Majesty The Queen In Right Of The Province Of Nova Scotia, As Represented By The Nova Scotia Agricultural College (Nsac) On Behalf Of The Minister Of The Agriculture Stable functional beverage compositions and processes for making same
KR101695488B1 (en) * 2013-12-06 2017-01-23 한명순 Composition for preventing and improving of diarrohea, and oral syringe package using the same
WO2015083982A1 (en) * 2013-12-06 2015-06-11 한명순 Composition for preventing and improving diarrhea and oral syringe package using same
EP3244905A4 (en) 2015-01-18 2018-12-12 Gavish-Galilee Bio Applications Ltd Extracts of edible fungi enriched in vitamin d and compositions thereof and their use in the treatment of immune-related disorders
WO2017201615A1 (en) * 2016-05-23 2017-11-30 Orphaderm Limited Biophotonic compositions comprising a fungal-derived chromophore
KR20180093725A (en) 2017-02-14 2018-08-22 강원대학교산학협력단 Pharmaceutical composition for treating or improving sepsis containing lentinan
CN108410944A (en) * 2018-06-05 2018-08-17 郑州安图生物工程股份有限公司 A kind of detection clostridium difficile culture medium and preparation method thereof
TWI673058B (en) * 2018-07-20 2019-10-01 金穎生物科技股份有限公司 Ganoderma lucidum complex polysaccharide composition
CN110403962A (en) * 2019-09-04 2019-11-05 湖南宇山玉月农业科技有限公司 A kind of application of Mycophyta in prevention and treatment chicken necrotizing enterocolitis
CN110656053B (en) * 2019-11-01 2021-04-13 广东省微生物研究所（广东省微生物分析检测中心） Lepidium new strain and artificial cultivation method and application thereof
FI130808B1 (en) * 2021-02-19 2024-03-27 Natural Resources Inst Finland Luke Fungi-derived composition, its production process and uses
IT202100029000A1 (en) 2021-11-16 2023-05-16 C I A M S R L IMMUNOSTIMULANT COMPOSITIONS FOR PETS

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US4247541A (en) * 1978-05-12 1981-01-27 Kirin Brewery Company Limited Ks-2-b
EP0292601A1 (en) * 1987-05-14 1988-11-30 Noda Shokukin Kogyo Co., Ltd. Anti aids drug extracted from lentinus edodes
WO1989012106A1 (en) * 1988-05-30 1989-12-14 Institut Pasteur Fungal exopolysaccharides having an immunostimulating activity, production method and therapeutical composition containing them
JPH06172217A (en) * 1991-05-21 1994-06-21 Taito Kk Immune effect enhancer for vaccine
WO2003020944A2 (en) * 2001-09-03 2003-03-13 Medimush Aps Production of fungal extracellular immune stimulating compounds

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US4247541A (en) * 1978-05-12 1981-01-27 Kirin Brewery Company Limited Ks-2-b
EP0292601A1 (en) * 1987-05-14 1988-11-30 Noda Shokukin Kogyo Co., Ltd. Anti aids drug extracted from lentinus edodes
WO1989012106A1 (en) * 1988-05-30 1989-12-14 Institut Pasteur Fungal exopolysaccharides having an immunostimulating activity, production method and therapeutical composition containing them
JPH06172217A (en) * 1991-05-21 1994-06-21 Taito Kk Immune effect enhancer for vaccine
WO2003020944A2 (en) * 2001-09-03 2003-03-13 Medimush Aps Production of fungal extracellular immune stimulating compounds

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JONG S C ET AL: "Medicinal and therapeutic value of the shiitake mushroom.", ADVANCES IN APPLIED MICROBIOLOGY. 1993, vol. 39, 1993, pages 153 - 184, XP008056557, ISSN: 0065-2164 *
KIM S W ET AL: "MYCELIAL GROWTH AND EXO-BIOPOLYMER PRODUCTION BY SUBMERGED CULTURE OF VARIOUS EDIBLE MUSHROOMS UNDER DIFFERENT MEDIA", LETTERS IN APPLIED MICROBIOLOGY, OXFORD, GB, vol. 34, 2002, pages 56 - 61, XP001051185 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249438B2 (en) 2001-09-03 2016-02-02 Glycanova As Production of fungal extracellular immune stimulating compounds

Also Published As

Publication number Publication date
JP2008525311A (en) 2008-07-17
CA2574060A1 (en) 2006-01-26
JP5926226B2 (en) 2016-05-25
TW200607863A (en) 2006-03-01
AU2005263329A1 (en) 2006-01-26
JP5502830B2 (en) 2014-05-28
WO2006007848A2 (en) 2006-01-26
EP1774012A2 (en) 2007-04-18
JP2012017347A (en) 2012-01-26
CA2574060C (en) 2019-06-25
JP2014005307A (en) 2014-01-16
IL180713A0 (en) 2007-06-03
KR20070057803A (en) 2007-06-07

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