CA2572331A1 - C-met modulators and method of use - Google Patents
C-met modulators and method of use Download PDFInfo
- Publication number
- CA2572331A1 CA2572331A1 CA002572331A CA2572331A CA2572331A1 CA 2572331 A1 CA2572331 A1 CA 2572331A1 CA 002572331 A CA002572331 A CA 002572331A CA 2572331 A CA2572331 A CA 2572331A CA 2572331 A1 CA2572331 A1 CA 2572331A1
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- Prior art keywords
- optionally substituted
- compound according
- 6alkyl
- mmol
- ring system
- Prior art date
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- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58497704P | 2004-07-02 | 2004-07-02 | |
| US60/584,977 | 2004-07-02 | ||
| PCT/US2005/023364 WO2006014325A2 (en) | 2004-07-02 | 2005-07-01 | C-met modulators and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2572331A1 true CA2572331A1 (en) | 2006-02-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA002572331A Abandoned CA2572331A1 (en) | 2004-07-02 | 2005-07-01 | C-met modulators and method of use |
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| Country | Link |
|---|---|
| US (1) | US7977345B2 (enExample) |
| EP (1) | EP1773826A4 (enExample) |
| JP (1) | JP5368701B2 (enExample) |
| AU (1) | AU2005270068B2 (enExample) |
| CA (1) | CA2572331A1 (enExample) |
| WO (1) | WO2006014325A2 (enExample) |
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| CN116836176A (zh) * | 2022-03-23 | 2023-10-03 | 中国科学院上海药物研究所 | 青蒿素类化合物、其制备方法和应用 |
| CN115160340B (zh) * | 2022-06-07 | 2023-07-21 | 四川大学华西医院 | 一种具有ack1抑制活性的小分子化合物及其应用 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| EP4622961A1 (en) * | 2022-11-25 | 2025-10-01 | Synthon B.V. | A process for preparation of cabozantinib or tivozanib |
| TW202444365A (zh) | 2023-01-31 | 2024-11-16 | 漢達生技醫藥股份有限公司 | 改良之卡博替尼組合物及其使用方法 |
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| US3149111A (en) * | 1961-09-29 | 1964-09-15 | Burroughs Wellcome Co | Dinitrophenylmercaptopurines |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| GB9604361D0 (en) * | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| BR9916746A (pt) * | 1999-06-03 | 2005-01-11 | Abbott Lab | Compostos anti-inflamatórios que inibem adesão de célula |
| US7135466B2 (en) * | 1999-12-24 | 2006-11-14 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives and drugs containing the same |
| MX242553B (es) | 2000-10-20 | 2006-12-06 | Eisai Co Ltd | Derivados aromaticos que contienen nitrogeno. |
| US7425564B2 (en) | 2001-06-22 | 2008-09-16 | Kirin Beer Kabushiki Kaisha | Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same |
| JP4224979B2 (ja) * | 2002-04-09 | 2009-02-18 | 大正製薬株式会社 | インターロイキン１２抑制剤 |
| RU2004135386A (ru) * | 2002-05-06 | 2005-07-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Тиадиазолы или оксадиазолы и их применение в качестве ингибиторов протеинкиназы jak |
| GB0219746D0 (en) | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
| WO2005005389A2 (en) | 2003-07-07 | 2005-01-20 | Merck Patent Gmbh | Malonamide derivatives |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
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- 2005-07-01 CA CA002572331A patent/CA2572331A1/en not_active Abandoned
- 2005-07-01 JP JP2007520386A patent/JP5368701B2/ja not_active Expired - Fee Related
- 2005-07-01 AU AU2005270068A patent/AU2005270068B2/en not_active Ceased
- 2005-07-01 EP EP05763620A patent/EP1773826A4/en not_active Withdrawn
- 2005-07-01 WO PCT/US2005/023364 patent/WO2006014325A2/en not_active Ceased
- 2005-07-01 US US11/571,140 patent/US7977345B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008505181A (ja) | 2008-02-21 |
| AU2005270068A1 (en) | 2006-02-09 |
| AU2005270068B2 (en) | 2012-04-19 |
| US20070179130A1 (en) | 2007-08-02 |
| EP1773826A2 (en) | 2007-04-18 |
| US7977345B2 (en) | 2011-07-12 |
| WO2006014325A3 (en) | 2007-03-01 |
| EP1773826A4 (en) | 2009-06-03 |
| WO2006014325A2 (en) | 2006-02-09 |
| JP5368701B2 (ja) | 2013-12-18 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150702 |