CA2566363C - High affinity ny-eso t cell receptor - Google Patents
High affinity ny-eso t cell receptor Download PDFInfo
- Publication number
- CA2566363C CA2566363C CA2566363A CA2566363A CA2566363C CA 2566363 C CA2566363 C CA 2566363C CA 2566363 A CA2566363 A CA 2566363A CA 2566363 A CA2566363 A CA 2566363A CA 2566363 C CA2566363 C CA 2566363C
- Authority
- CA
- Canada
- Prior art keywords
- ser
- leu
- tcr
- gly
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108091008874 T cell receptors Proteins 0.000 title claims abstract description 492
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title claims abstract description 486
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 52
- 230000027455 binding Effects 0.000 claims abstract description 36
- 210000004027 cell Anatomy 0.000 claims description 93
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 62
- 206010028980 Neoplasm Diseases 0.000 claims description 39
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- 238000000034 method Methods 0.000 claims description 33
- 125000005647 linker group Chemical group 0.000 claims description 32
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- 229940124597 therapeutic agent Drugs 0.000 claims description 23
- 235000001014 amino acid Nutrition 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 19
- 229920001223 polyethylene glycol Polymers 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 17
- 241000282414 Homo sapiens Species 0.000 claims description 14
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims description 14
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims description 14
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 11
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims description 10
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims description 10
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 10
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