CA2541634A1 - Inhibitors of serine proteases, particularly hcv ns3-ns4a protease - Google Patents

Inhibitors of serine proteases, particularly hcv ns3-ns4a protease Download PDF

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Publication number
CA2541634A1
CA2541634A1 CA002541634A CA2541634A CA2541634A1 CA 2541634 A1 CA2541634 A1 CA 2541634A1 CA 002541634 A CA002541634 A CA 002541634A CA 2541634 A CA2541634 A CA 2541634A CA 2541634 A1 CA2541634 A1 CA 2541634A1
Authority
CA
Canada
Prior art keywords
ring
aliphatic
cycloalkyl
aryl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002541634A
Other languages
English (en)
French (fr)
Inventor
Kevin M. Cottrell
Robert B. Perni
Janos Pitlik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Incorporated
Kevin M. Cottrell
Robert B. Perni
Janos Pitlik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated, Kevin M. Cottrell, Robert B. Perni, Janos Pitlik filed Critical Vertex Pharmaceuticals Incorporated
Publication of CA2541634A1 publication Critical patent/CA2541634A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
CA002541634A 2003-10-10 2004-10-08 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease Abandoned CA2541634A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51015603P 2003-10-10 2003-10-10
US60/510,156 2003-10-10
US51376803P 2003-10-23 2003-10-23
US60/513,768 2003-10-23
PCT/US2004/033238 WO2005037860A2 (en) 2003-10-10 2004-10-08 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Publications (1)

Publication Number Publication Date
CA2541634A1 true CA2541634A1 (en) 2005-04-28

Family

ID=34467967

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002541634A Abandoned CA2541634A1 (en) 2003-10-10 2004-10-08 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Country Status (14)

Country Link
US (2) US7208600B2 (US08039623-20111018-C00115.png)
EP (2) EP1692157B1 (US08039623-20111018-C00115.png)
JP (2) JP2007532474A (US08039623-20111018-C00115.png)
KR (2) KR20120010278A (US08039623-20111018-C00115.png)
CN (1) CN101857631A (US08039623-20111018-C00115.png)
AU (1) AU2004282148A1 (US08039623-20111018-C00115.png)
CA (1) CA2541634A1 (US08039623-20111018-C00115.png)
IL (1) IL174863A0 (US08039623-20111018-C00115.png)
MX (1) MXPA06004006A (US08039623-20111018-C00115.png)
NO (1) NO20062101L (US08039623-20111018-C00115.png)
NZ (1) NZ546663A (US08039623-20111018-C00115.png)
RU (1) RU2006115558A (US08039623-20111018-C00115.png)
TW (1) TW200528472A (US08039623-20111018-C00115.png)
WO (1) WO2005037860A2 (US08039623-20111018-C00115.png)

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US8039623B2 (en) 2011-10-18
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US7208600B2 (en) 2007-04-24
TW200528472A (en) 2005-09-01
WO2005037860A2 (en) 2005-04-28
JP2011246487A (ja) 2011-12-08
EP1692157B1 (en) 2013-04-17
NO20062101L (no) 2006-07-05
EP1692157A2 (en) 2006-08-23
AU2004282148A1 (en) 2005-04-28
RU2006115558A (ru) 2007-11-20
US20050137140A1 (en) 2005-06-23
JP2007532474A (ja) 2007-11-15
KR20120010278A (ko) 2012-02-02
MXPA06004006A (es) 2006-06-28
KR20060130027A (ko) 2006-12-18
US20070161789A1 (en) 2007-07-12
CN101857631A (zh) 2010-10-13
IL174863A0 (en) 2008-02-09
EP2361925A1 (en) 2011-08-31

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