CA2529252A1 - Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid - Google Patents
Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid Download PDFInfo
- Publication number
- CA2529252A1 CA2529252A1 CA002529252A CA2529252A CA2529252A1 CA 2529252 A1 CA2529252 A1 CA 2529252A1 CA 002529252 A CA002529252 A CA 002529252A CA 2529252 A CA2529252 A CA 2529252A CA 2529252 A1 CA2529252 A1 CA 2529252A1
- Authority
- CA
- Canada
- Prior art keywords
- ethyl
- phenyl
- phenoxy
- methylsulfonyl
- oxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314260.1A GB0314260D0 (en) | 2003-06-19 | 2003-06-19 | Therapeutic agents |
| GB0314260.1 | 2003-06-19 | ||
| PCT/GB2004/002599 WO2004113285A1 (en) | 2003-06-19 | 2004-06-16 | Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2529252A1 true CA2529252A1 (en) | 2004-12-29 |
Family
ID=27636892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002529252A Abandoned CA2529252A1 (en) | 2003-06-19 | 2004-06-16 | Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7429675B2 (enExample) |
| EP (1) | EP1638929A1 (enExample) |
| JP (1) | JP2006527751A (enExample) |
| KR (1) | KR20060010840A (enExample) |
| CN (1) | CN1835918A (enExample) |
| AU (1) | AU2004249487A1 (enExample) |
| BR (1) | BRPI0411450A (enExample) |
| CA (1) | CA2529252A1 (enExample) |
| GB (1) | GB0314260D0 (enExample) |
| IL (1) | IL172376A0 (enExample) |
| MX (1) | MXPA05013716A (enExample) |
| NO (1) | NO20055883L (enExample) |
| WO (1) | WO2004113285A1 (enExample) |
| ZA (1) | ZA200509944B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| WO2004000790A1 (en) | 2002-06-20 | 2003-12-31 | Astrazeneca Ab | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
| GB0314075D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0427524D0 (en) | 2004-12-16 | 2005-01-19 | Astrazeneca Ab | Chemical process |
| EP2125711B1 (en) * | 2007-03-08 | 2013-11-06 | Albireo Ab | 3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease |
| FR2986804A1 (fr) * | 2012-02-09 | 2013-08-16 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61197530A (ja) | 1985-02-25 | 1986-09-01 | Mitsubishi Gas Chem Co Inc | ラセミ化法 |
| DE3683512D1 (de) | 1985-02-25 | 1992-03-05 | Mitsubishi Gas Chemical Co | Verfahren zur optischen isomerisierung von optisch aktiver aminosaeure und verfahren zur herstellung von optisch aktiver aminosaeure. |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| MA26634A1 (fr) | 1998-06-04 | 2004-12-20 | Astra Ab | Nouveaux derives de l'acide 3-aryl propionique et analogues |
| SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
-
2003
- 2003-06-19 GB GBGB0314260.1A patent/GB0314260D0/en not_active Ceased
-
2004
- 2004-06-16 CN CNA2004800231458A patent/CN1835918A/zh active Pending
- 2004-06-16 US US10/561,161 patent/US7429675B2/en not_active Expired - Fee Related
- 2004-06-16 BR BRPI0411450-7A patent/BRPI0411450A/pt not_active IP Right Cessation
- 2004-06-16 CA CA002529252A patent/CA2529252A1/en not_active Abandoned
- 2004-06-16 WO PCT/GB2004/002599 patent/WO2004113285A1/en not_active Ceased
- 2004-06-16 AU AU2004249487A patent/AU2004249487A1/en not_active Abandoned
- 2004-06-16 EP EP04736920A patent/EP1638929A1/en not_active Withdrawn
- 2004-06-16 JP JP2006516435A patent/JP2006527751A/ja not_active Withdrawn
- 2004-06-16 MX MXPA05013716A patent/MXPA05013716A/es unknown
- 2004-06-16 KR KR1020057024130A patent/KR20060010840A/ko not_active Withdrawn
-
2005
- 2005-12-05 IL IL172376A patent/IL172376A0/en unknown
- 2005-12-07 ZA ZA200509944A patent/ZA200509944B/en unknown
- 2005-12-12 NO NO20055883A patent/NO20055883L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL172376A0 (en) | 2009-02-11 |
| ZA200509944B (en) | 2006-12-27 |
| KR20060010840A (ko) | 2006-02-02 |
| BRPI0411450A (pt) | 2006-07-18 |
| CN1835918A (zh) | 2006-09-20 |
| NO20055883L (no) | 2006-01-09 |
| GB0314260D0 (en) | 2003-07-23 |
| AU2004249487A1 (en) | 2004-12-29 |
| WO2004113285A1 (en) | 2004-12-29 |
| US20060167309A1 (en) | 2006-07-27 |
| MXPA05013716A (es) | 2006-03-08 |
| JP2006527751A (ja) | 2006-12-07 |
| US7429675B2 (en) | 2008-09-30 |
| EP1638929A1 (en) | 2006-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |