CN1835918A - 外消旋2－{[2－(4－羟基苯基)乙基]硫基}－3－[4－(2－{4－[(甲磺酰基)氧基]苯氧基}乙基)苯基]－丙酸的制备方法 - Google Patents

外消旋2－{[2－(4－羟基苯基)乙基]硫基}－3－[4－(2－{4－[(甲磺酰基)氧基]苯氧基}乙基)苯基]－丙酸的制备方法 Download PDF

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Publication number
CN1835918A
CN1835918A CNA2004800231458A CN200480023145A CN1835918A CN 1835918 A CN1835918 A CN 1835918A CN A2004800231458 A CNA2004800231458 A CN A2004800231458A CN 200480023145 A CN200480023145 A CN 200480023145A CN 1835918 A CN1835918 A CN 1835918A
Authority
CN
China
Prior art keywords
ethyl
phenyl
methylsulfonyl
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800231458A
Other languages
English (en)
Chinese (zh)
Inventor
K·安德松
E·－L·林斯特德特－阿尔斯特马
H·索伦森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1835918A publication Critical patent/CN1835918A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNA2004800231458A 2003-06-19 2004-06-16 外消旋2－{[2－(4－羟基苯基)乙基]硫基}－3－[4－(2－{4－[(甲磺酰基)氧基]苯氧基}乙基)苯基]－丙酸的制备方法 Pending CN1835918A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0314260.1A GB0314260D0 (en) 2003-06-19 2003-06-19 Therapeutic agents
GB0314260.1 2003-06-19

Publications (1)

Publication Number Publication Date
CN1835918A true CN1835918A (zh) 2006-09-20

Family

ID=27636892

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800231458A Pending CN1835918A (zh) 2003-06-19 2004-06-16 外消旋2－{[2－(4－羟基苯基)乙基]硫基}－3－[4－(2－{4－[(甲磺酰基)氧基]苯氧基}乙基)苯基]－丙酸的制备方法

Country Status (14)

Country Link
US (1) US7429675B2 (enExample)
EP (1) EP1638929A1 (enExample)
JP (1) JP2006527751A (enExample)
KR (1) KR20060010840A (enExample)
CN (1) CN1835918A (enExample)
AU (1) AU2004249487A1 (enExample)
BR (1) BRPI0411450A (enExample)
CA (1) CA2529252A1 (enExample)
GB (1) GB0314260D0 (enExample)
IL (1) IL172376A0 (enExample)
MX (1) MXPA05013716A (enExample)
NO (1) NO20055883L (enExample)
WO (1) WO2004113285A1 (enExample)
ZA (1) ZA200509944B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI467019B (zh) * 2012-02-09 2015-01-01 Servier Lab （７ｓ）－３，４－二甲氧基雙環［４．２．０］辛－１，３，５－三烯－７－羧酸或其酯類之酵素合成方法及於依伐布雷定（ｉｖａｂｒａｄｉｎｅ）及其鹽類合成之應用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
TWI282784B (en) 2002-06-20 2007-06-21 Astrazeneca Ab Therapeutic agents
GB0314075D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0427524D0 (en) 2004-12-16 2005-01-19 Astrazeneca Ab Chemical process
JP5404429B2 (ja) * 2007-03-08 2014-01-29 アルビレオ・アクチボラグ ２−置換３−フェニルプロピオン酸誘導体および炎症性腸疾患の治療におけるそれらの使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197530A (ja) * 1985-02-25 1986-09-01 Mitsubishi Gas Chem Co Inc ラセミ化法
DE3683512D1 (de) 1985-02-25 1992-03-05 Mitsubishi Gas Chemical Co Verfahren zur optischen isomerisierung von optisch aktiver aminosaeure und verfahren zur herstellung von optisch aktiver aminosaeure.
TW472047B (en) * 1994-02-04 2002-01-11 Merck & Co Inc Process for making HIV protease inhibitors
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
MA26634A1 (fr) * 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE0104333D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI467019B (zh) * 2012-02-09 2015-01-01 Servier Lab （７ｓ）－３，４－二甲氧基雙環［４．２．０］辛－１，３，５－三烯－７－羧酸或其酯類之酵素合成方法及於依伐布雷定（ｉｖａｂｒａｄｉｎｅ）及其鹽類合成之應用

Also Published As

Publication number Publication date
MXPA05013716A (es) 2006-03-08
GB0314260D0 (en) 2003-07-23
AU2004249487A1 (en) 2004-12-29
KR20060010840A (ko) 2006-02-02
ZA200509944B (en) 2006-12-27
NO20055883L (no) 2006-01-09
US7429675B2 (en) 2008-09-30
BRPI0411450A (pt) 2006-07-18
US20060167309A1 (en) 2006-07-27
JP2006527751A (ja) 2006-12-07
WO2004113285A1 (en) 2004-12-29
EP1638929A1 (en) 2006-03-29
CA2529252A1 (en) 2004-12-29
IL172376A0 (en) 2009-02-11

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