IL172376A0 - Process for the preparation of racemic 2{[2-(4- hydroxyphenyl)ethyl]thio}-3-[4-(2-{4- [(methylsulphonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid - Google Patents

Process for the preparation of racemic 2{[2-(4- hydroxyphenyl)ethyl]thio}-3-[4-(2-{4- [(methylsulphonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid

Info

Publication number
IL172376A0
IL172376A0 IL172376A IL17237605A IL172376A0 IL 172376 A0 IL172376 A0 IL 172376A0 IL 172376 A IL172376 A IL 172376A IL 17237605 A IL17237605 A IL 17237605A IL 172376 A0 IL172376 A0 IL 172376A0
Authority
IL
Israel
Prior art keywords
ethyl
methylsulphonyl
racemic
thio
hydroxyphenyl
Prior art date
Application number
IL172376A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Eva Lotte Lindstedt Alstermark
Kjell Andersson
Sorensen Henrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Eva Lotte Lindstedt Alstermark, Kjell Andersson, Sorensen Henrik filed Critical Astrazeneca Ab
Publication of IL172376A0 publication Critical patent/IL172376A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL172376A 2003-06-19 2005-12-05 Process for the preparation of racemic 2{[2-(4- hydroxyphenyl)ethyl]thio}-3-[4-(2-{4- [(methylsulphonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid IL172376A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0314260.1A GB0314260D0 (en) 2003-06-19 2003-06-19 Therapeutic agents
PCT/GB2004/002599 WO2004113285A1 (en) 2003-06-19 2004-06-16 Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid

Publications (1)

Publication Number Publication Date
IL172376A0 true IL172376A0 (en) 2009-02-11

Family

ID=27636892

Family Applications (1)

Application Number Title Priority Date Filing Date
IL172376A IL172376A0 (en) 2003-06-19 2005-12-05 Process for the preparation of racemic 2{[2-(4- hydroxyphenyl)ethyl]thio}-3-[4-(2-{4- [(methylsulphonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid

Country Status (14)

Country Link
US (1) US7429675B2 (enExample)
EP (1) EP1638929A1 (enExample)
JP (1) JP2006527751A (enExample)
KR (1) KR20060010840A (enExample)
CN (1) CN1835918A (enExample)
AU (1) AU2004249487A1 (enExample)
BR (1) BRPI0411450A (enExample)
CA (1) CA2529252A1 (enExample)
GB (1) GB0314260D0 (enExample)
IL (1) IL172376A0 (enExample)
MX (1) MXPA05013716A (enExample)
NO (1) NO20055883L (enExample)
WO (1) WO2004113285A1 (enExample)
ZA (1) ZA200509944B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
PL375074A1 (en) 2002-06-20 2005-11-14 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
GB0314075D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0427524D0 (en) 2004-12-16 2005-01-19 Astrazeneca Ab Chemical process
KR101558005B1 (ko) * 2007-03-08 2015-10-06 알비레오 에이비 2-치환-3-페닐프로피온산 유도체 및 염증성 장 질환 치료에서의 그의 용도
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197530A (ja) 1985-02-25 1986-09-01 Mitsubishi Gas Chem Co Inc ラセミ化法
EP0193113B1 (en) * 1985-02-25 1992-01-22 Mitsubishi Gas Chemical Company, Inc. Process for optically isomerizing optically active alpha-amino acid amides and process for producing optically active alpha-amino acids
TW472047B (en) * 1994-02-04 2002-01-11 Merck & Co Inc Process for making HIV protease inhibitors
MA26634A1 (fr) * 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
SE0104333D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date
NO20055883L (no) 2006-01-09
CA2529252A1 (en) 2004-12-29
MXPA05013716A (es) 2006-03-08
EP1638929A1 (en) 2006-03-29
US7429675B2 (en) 2008-09-30
US20060167309A1 (en) 2006-07-27
KR20060010840A (ko) 2006-02-02
BRPI0411450A (pt) 2006-07-18
GB0314260D0 (en) 2003-07-23
WO2004113285A1 (en) 2004-12-29
CN1835918A (zh) 2006-09-20
JP2006527751A (ja) 2006-12-07
AU2004249487A1 (en) 2004-12-29
ZA200509944B (en) 2006-12-27

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