CA2522845A1 - Kinase inhibitor phosphonate conjugates - Google Patents
Kinase inhibitor phosphonate conjugates Download PDFInfo
- Publication number
- CA2522845A1 CA2522845A1 CA002522845A CA2522845A CA2522845A1 CA 2522845 A1 CA2522845 A1 CA 2522845A1 CA 002522845 A CA002522845 A CA 002522845A CA 2522845 A CA2522845 A CA 2522845A CA 2522845 A1 CA2522845 A1 CA 2522845A1
- Authority
- CA
- Canada
- Prior art keywords
- conjugate
- formula
- kinase
- compound
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940043355 kinase inhibitor Drugs 0.000 title claims description 13
- 239000003757 phosphotransferase inhibitor Substances 0.000 title claims description 13
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 title description 126
- 150000001875 compounds Chemical class 0.000 claims abstract description 335
- 238000000034 method Methods 0.000 claims abstract description 239
- 239000000203 mixture Substances 0.000 claims abstract description 92
- 108091000080 Phosphotransferase Proteins 0.000 claims abstract description 47
- 102000020233 phosphotransferase Human genes 0.000 claims abstract description 47
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 23
- 229910052760 oxygen Inorganic materials 0.000 claims description 112
- 229910052757 nitrogen Inorganic materials 0.000 claims description 91
- 125000004432 carbon atom Chemical group C* 0.000 claims description 85
- 125000006239 protecting group Chemical group 0.000 claims description 73
- 229940024606 amino acid Drugs 0.000 claims description 49
- 125000000217 alkyl group Chemical group 0.000 claims description 48
- 239000004480 active ingredient Substances 0.000 claims description 47
- 150000001413 amino acids Chemical class 0.000 claims description 47
- 239000003814 drug Substances 0.000 claims description 47
- 229910052717 sulfur Inorganic materials 0.000 claims description 45
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 40
- 125000001424 substituent group Chemical group 0.000 claims description 40
- 125000000623 heterocyclic group Chemical group 0.000 claims description 39
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Landscapes
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Applications Claiming Priority (37)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46556903P | 2003-04-25 | 2003-04-25 | |
| US46558803P | 2003-04-25 | 2003-04-25 | |
| US46546503P | 2003-04-25 | 2003-04-25 | |
| US46559403P | 2003-04-25 | 2003-04-25 | |
| US60/465,594 | 2003-04-25 | ||
| US60/465,588 | 2003-04-25 | ||
| US60/465,465 | 2003-04-25 | ||
| US60/465,569 | 2003-04-25 | ||
| US49568603P | 2003-08-15 | 2003-08-15 | |
| US49538203P | 2003-08-15 | 2003-08-15 | |
| US49568503P | 2003-08-15 | 2003-08-15 | |
| US49552703P | 2003-08-15 | 2003-08-15 | |
| US60/495,382 | 2003-08-15 | ||
| US60/495,527 | 2003-08-15 | ||
| US60/495,686 | 2003-08-15 | ||
| US60/495,685 | 2003-08-15 | ||
| US51397403P | 2003-10-24 | 2003-10-24 | |
| US51420703P | 2003-10-24 | 2003-10-24 | |
| US51433003P | 2003-10-24 | 2003-10-24 | |
| US51411503P | 2003-10-24 | 2003-10-24 | |
| US51392503P | 2003-10-24 | 2003-10-24 | |
| US51395603P | 2003-10-24 | 2003-10-24 | |
| US51432403P | 2003-10-24 | 2003-10-24 | |
| US51436803P | 2003-10-24 | 2003-10-24 | |
| US60/514,330 | 2003-10-24 | ||
| US60/514,207 | 2003-10-24 | ||
| US60/513,925 | 2003-10-24 | ||
| US60/513,974 | 2003-10-24 | ||
| US60/514,324 | 2003-10-24 | ||
| US60/513,956 | 2003-10-24 | ||
| US60/514,115 | 2003-10-24 | ||
| US60/514,368 | 2003-10-24 | ||
| US53193203P | 2003-12-22 | 2003-12-22 | |
| US60/531,932 | 2003-12-22 | ||
| US53605404P | 2004-01-12 | 2004-01-12 | |
| PCT/US2004/013062 WO2004096234A2 (en) | 2003-04-25 | 2004-04-26 | Kinase inhibitor phosphonate conjugates |
| US60/536,054 | 2004-12-02 |
Publications (1)
| Publication Number | Publication Date |
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| CA2522845A1 true CA2522845A1 (en) | 2004-11-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002522845A Abandoned CA2522845A1 (en) | 2003-04-25 | 2004-04-26 | Kinase inhibitor phosphonate conjugates |
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|---|---|
| US (2) | US7417055B2 (enExample) |
| EP (1) | EP1620109A2 (enExample) |
| JP (2) | JP2006524710A (enExample) |
| KR (1) | KR20060022647A (enExample) |
| AU (1) | AU2004233897A1 (enExample) |
| CA (1) | CA2522845A1 (enExample) |
| EA (1) | EA200501676A1 (enExample) |
| MX (1) | MXPA05011296A (enExample) |
| NO (1) | NO20055590L (enExample) |
| WO (1) | WO2004096234A2 (enExample) |
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-
2004
- 2004-04-26 EP EP04750806A patent/EP1620109A2/en not_active Withdrawn
- 2004-04-26 CA CA002522845A patent/CA2522845A1/en not_active Abandoned
- 2004-04-26 KR KR1020057020117A patent/KR20060022647A/ko not_active Withdrawn
- 2004-04-26 WO PCT/US2004/013062 patent/WO2004096234A2/en not_active Ceased
- 2004-04-26 EA EA200501676A patent/EA200501676A1/ru unknown
- 2004-04-26 JP JP2006513386A patent/JP2006524710A/ja not_active Withdrawn
- 2004-04-26 US US10/832,811 patent/US7417055B2/en not_active Expired - Fee Related
- 2004-04-26 AU AU2004233897A patent/AU2004233897A1/en not_active Abandoned
- 2004-04-26 MX MXPA05011296A patent/MXPA05011296A/es not_active Application Discontinuation
-
2005
- 2005-11-25 NO NO20055590A patent/NO20055590L/no not_active Application Discontinuation
-
2007
- 2007-04-24 JP JP2007114889A patent/JP2007291111A/ja not_active Withdrawn
-
2008
- 2008-07-02 US US12/167,038 patent/US20090181930A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004233897A1 (en) | 2004-11-11 |
| KR20060022647A (ko) | 2006-03-10 |
| JP2006524710A (ja) | 2006-11-02 |
| NO20055590L (no) | 2006-01-24 |
| MXPA05011296A (es) | 2006-01-24 |
| US20090181930A1 (en) | 2009-07-16 |
| NO20055590D0 (no) | 2005-11-25 |
| US7417055B2 (en) | 2008-08-26 |
| WO2004096234A2 (en) | 2004-11-11 |
| JP2007291111A (ja) | 2007-11-08 |
| US20050261253A1 (en) | 2005-11-24 |
| EP1620109A2 (en) | 2006-02-01 |
| WO2004096234A3 (en) | 2005-01-27 |
| EA200501676A1 (ru) | 2006-04-28 |
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