CA2508722A1 - Controlled-release of an active substance into a high fat environment - Google Patents
Controlled-release of an active substance into a high fat environment Download PDFInfo
- Publication number
- CA2508722A1 CA2508722A1 CA002508722A CA2508722A CA2508722A1 CA 2508722 A1 CA2508722 A1 CA 2508722A1 CA 002508722 A CA002508722 A CA 002508722A CA 2508722 A CA2508722 A CA 2508722A CA 2508722 A1 CA2508722 A1 CA 2508722A1
- Authority
- CA
- Canada
- Prior art keywords
- use environment
- composition
- release
- fold
- controlled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43286002P | 2002-12-11 | 2002-12-11 | |
| US60/432,860 | 2002-12-11 | ||
| PCT/IB2003/005629 WO2004052343A1 (en) | 2002-12-11 | 2003-11-28 | Controlled-release of an active substance into a high fat environment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2508722A1 true CA2508722A1 (en) | 2004-06-24 |
Family
ID=32508002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002508722A Abandoned CA2508722A1 (en) | 2002-12-11 | 2003-11-28 | Controlled-release of an active substance into a high fat environment |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040121015A1 (https=) |
| EP (1) | EP1572163A1 (https=) |
| JP (1) | JP2006510655A (https=) |
| KR (1) | KR20050088311A (https=) |
| CN (1) | CN1726012A (https=) |
| AR (1) | AR042340A1 (https=) |
| AU (1) | AU2003283688A1 (https=) |
| BR (1) | BR0317275A (https=) |
| CA (1) | CA2508722A1 (https=) |
| CO (1) | CO5570656A2 (https=) |
| MX (1) | MXPA05005812A (https=) |
| NO (1) | NO20053068L (https=) |
| NZ (1) | NZ539915A (https=) |
| PL (1) | PL377479A1 (https=) |
| RU (1) | RU2308263C2 (https=) |
| TW (1) | TWI257302B (https=) |
| WO (1) | WO2004052343A1 (https=) |
| ZA (1) | ZA200503812B (https=) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030086972A1 (en) * | 2000-08-09 | 2003-05-08 | Appel Leah E. | Hydrogel-driven drug dosage form |
| FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| KR20050005437A (ko) * | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| US20090088465A1 (en) * | 2004-12-02 | 2009-04-02 | Stephen Craig Dyar | Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same |
| US20080138428A1 (en) * | 2005-01-28 | 2008-06-12 | Pfizer Inc. | Fast-Disintegrating Microporous Binders |
| US8431156B2 (en) * | 2005-02-22 | 2013-04-30 | Sun Pharma Advanced Research Company Ltd. | Pharmaceutical composition |
| JP5666087B2 (ja) * | 2005-04-06 | 2015-02-12 | アダマス・ファーマシューティカルズ・インコーポレーテッド | Cns関連疾患の治療のための方法及び組成物 |
| EP2671507A3 (en) | 2005-04-28 | 2014-02-19 | Proteus Digital Health, Inc. | Pharma-informatics system |
| US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
| US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
| US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
| US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
| US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
| FR2886150B1 (fr) * | 2005-05-24 | 2007-08-24 | Flamel Technologies Sa | Forme pharmaceutique orale a base d'au moins un principe actif dont la solubilite varie en fonction des conditions de ph gastrique |
| US8547248B2 (en) | 2005-09-01 | 2013-10-01 | Proteus Digital Health, Inc. | Implantable zero-wire communications system |
| EP2013829A4 (en) | 2006-05-02 | 2010-07-07 | Proteus Biomedical Inc | PERSONALIZED THERAPEUTIC REGIMES FOR A PATIENT |
| WO2008066617A2 (en) | 2006-10-17 | 2008-06-05 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
| WO2008052136A2 (en) * | 2006-10-25 | 2008-05-02 | Proteus Biomedical, Inc. | Controlled activation ingestible identifier |
| EP2069004A4 (en) | 2006-11-20 | 2014-07-09 | Proteus Digital Health Inc | PERSONAL HEALTH SIGNAL RECEIVERS WITH ACTIVE SIGNAL PROCESSING |
| EP3785599B1 (en) | 2007-02-01 | 2022-08-03 | Otsuka Pharmaceutical Co., Ltd. | Ingestible event marker systems |
| US8956288B2 (en) * | 2007-02-14 | 2015-02-17 | Proteus Digital Health, Inc. | In-body power source having high surface area electrode |
| EP2124725A1 (en) | 2007-03-09 | 2009-12-02 | Proteus Biomedical, Inc. | In-body device having a multi-directional transmitter |
| EP2063771A1 (en) | 2007-03-09 | 2009-06-03 | Proteus Biomedical, Inc. | In-body device having a deployable antenna |
| US20080299188A1 (en) * | 2007-05-14 | 2008-12-04 | Pfizer Inc. | Controlled release dosage forms combining immediate release and sustainted release of low-solubility drug |
| US8115618B2 (en) | 2007-05-24 | 2012-02-14 | Proteus Biomedical, Inc. | RFID antenna for in-body device |
| ES2928197T3 (es) | 2007-09-25 | 2022-11-16 | Otsuka Pharma Co Ltd | Dispositivo intracorpóreo con amplificación de señal de dipolo virtual |
| US8789536B2 (en) | 2007-10-17 | 2014-07-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US20090105561A1 (en) * | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
| US8707964B2 (en) * | 2007-10-31 | 2014-04-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8808276B2 (en) * | 2007-10-23 | 2014-08-19 | The Invention Science Fund I, Llc | Adaptive dispensation in a digestive tract |
| US20090163894A1 (en) * | 2007-10-31 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
| US8808271B2 (en) * | 2007-10-31 | 2014-08-19 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| KR100920106B1 (ko) * | 2007-11-14 | 2009-10-01 | 경북대학교 산학협력단 | 구연산 실데나필을 경피적으로 전달하기 위한 조절 약물전달체 및 이를 포함하는 경피 패치 |
| CN101926097B (zh) | 2007-11-27 | 2016-10-05 | 普罗透斯数字保健公司 | 采用通信信道的穿体通信系统 |
| DK3235491T3 (da) | 2008-03-05 | 2021-02-08 | Otsuka Pharma Co Ltd | Spiselige hændelsesmarkeringsenheder og systemer med multimodus-kommunikation |
| DK2313002T3 (en) | 2008-07-08 | 2018-12-03 | Proteus Digital Health Inc | Data basis for edible event fields |
| CN104382598A (zh) | 2008-08-13 | 2015-03-04 | 普罗透斯数字保健公司 | 一种产生识别器的方法 |
| CN117530912A (zh) | 2008-08-15 | 2024-02-09 | 硬木药品公司 | 适合口服给药的鸟苷酸环化酶-c受体激动剂多肽的稳定的固体制剂 |
| AU2009313879B2 (en) * | 2008-11-13 | 2011-10-20 | Proteus Digital Health, Inc. | Ingestible therapy activator system and method |
| US8055334B2 (en) * | 2008-12-11 | 2011-11-08 | Proteus Biomedical, Inc. | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same |
| US9439566B2 (en) | 2008-12-15 | 2016-09-13 | Proteus Digital Health, Inc. | Re-wearable wireless device |
| US9659423B2 (en) | 2008-12-15 | 2017-05-23 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
| TWI503101B (zh) | 2008-12-15 | 2015-10-11 | 波提亞斯數位康健公司 | 與身體有關的接收器及其方法 |
| CA2750148C (en) | 2009-01-06 | 2017-02-07 | Proteus Biomedical, Inc. | Pharmaceutical dosages delivery system |
| AU2010203625A1 (en) | 2009-01-06 | 2011-07-21 | Proteus Digital Health, Inc. | Ingestion-related biofeedback and personalized medical therapy method and system |
| GB2480965B (en) | 2009-03-25 | 2014-10-08 | Proteus Digital Health Inc | Probablistic pharmacokinetic and pharmacodynamic modeling |
| BR122013009559A2 (pt) | 2009-04-28 | 2019-08-06 | Proteus Digital Health, Inc. | Marcadores de evento de ingerível altamente confiável e métodos para usar os mesmos |
| EP2432458A4 (en) | 2009-05-12 | 2014-02-12 | Proteus Digital Health Inc | ACCEPTABLE EVENT MARKER WITH SUGAR COMPONENT |
| CA2770077A1 (en) | 2009-08-06 | 2011-02-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| WO2011022732A2 (en) | 2009-08-21 | 2011-02-24 | Proteus Biomedical, Inc. | Apparatus and method for measuring biochemical parameters |
| TWI517050B (zh) | 2009-11-04 | 2016-01-11 | 普羅托斯數位健康公司 | 供應鏈管理之系統 |
| UA109424C2 (uk) | 2009-12-02 | 2015-08-25 | Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки | |
| KR101798128B1 (ko) | 2010-02-01 | 2017-11-16 | 프로테우스 디지털 헬스, 인코포레이티드 | 데이터 수집 시스템 |
| KR101193495B1 (ko) * | 2010-02-01 | 2012-10-23 | 한미사이언스 주식회사 | 슈도에페드린 및 레보세티리진을 포함하는 경구용 복합 조성물 |
| US8933030B2 (en) | 2010-02-17 | 2015-01-13 | Ironwwod Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| WO2011127252A2 (en) | 2010-04-07 | 2011-10-13 | Proteus Biomedical, Inc. | Miniature ingestible device |
| TWI557672B (zh) | 2010-05-19 | 2016-11-11 | 波提亞斯數位康健公司 | 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置 |
| DK2603232T3 (da) | 2010-08-11 | 2019-12-09 | Ironwood Pharmaceuticals Inc | Stabile formuleringer af linaclotid |
| US9107806B2 (en) | 2010-11-22 | 2015-08-18 | Proteus Digital Health, Inc. | Ingestible device with pharmaceutical product |
| EP2683291B1 (en) | 2011-03-11 | 2019-07-31 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
| US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| BR112014001397A2 (pt) | 2011-07-21 | 2017-02-21 | Proteus Biomedical Inc | dispositivo, sistema e método de comunicação móvel |
| US9708371B2 (en) | 2011-08-17 | 2017-07-18 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
| EP2874886B1 (en) | 2012-07-23 | 2023-12-20 | Otsuka Pharmaceutical Co., Ltd. | Techniques for manufacturing ingestible event markers comprising an ingestible component |
| US9268909B2 (en) | 2012-10-18 | 2016-02-23 | Proteus Digital Health, Inc. | Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device |
| JP2016508529A (ja) | 2013-01-29 | 2016-03-22 | プロテウス デジタル ヘルス, インコーポレイテッド | 高度に膨張可能なポリマーフィルムおよびこれを含む組成物 |
| US10175376B2 (en) | 2013-03-15 | 2019-01-08 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
| WO2014151929A1 (en) | 2013-03-15 | 2014-09-25 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
| JP6511439B2 (ja) | 2013-06-04 | 2019-05-15 | プロテウス デジタル ヘルス, インコーポレイテッド | データ収集および転帰の査定のためのシステム、装置、および方法 |
| US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
| WO2015042411A1 (en) | 2013-09-20 | 2015-03-26 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
| JP2016537924A (ja) | 2013-09-24 | 2016-12-01 | プロテウス デジタル ヘルス, インコーポレイテッド | 事前に正確に把握されていない周波数において受信された電磁信号に関する使用のための方法および装置 |
| US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
| US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
| SG10202101937PA (en) | 2016-07-22 | 2021-03-30 | Proteus Digital Health Inc | Electromagnetic sensing and detection of ingestible event markers |
| WO2018081337A1 (en) | 2016-10-26 | 2018-05-03 | Proteus Digital Health, Inc. | Methods for manufacturing capsules with ingestible event markers |
| CN111214456A (zh) * | 2020-03-10 | 2020-06-02 | 浙江普利药业有限公司 | 伏立康唑干混悬剂及其制备方法 |
| PE20231844A1 (es) * | 2020-07-30 | 2023-11-21 | Faes Farma Sa | Sistema de liberacion de farmacos descongestivos y bilastina |
| CN112198274B (zh) * | 2020-11-02 | 2022-04-05 | 北京市理化分析测试中心 | 一种检测氨酚伪麻片中盐酸伪麻黄碱的方法 |
| CN113514579A (zh) * | 2021-06-23 | 2021-10-19 | 远大生命科学(武汉)有限公司 | 一种依托咪酯乳状注射液体外释放曲线的测定方法 |
| CN115647000B (zh) * | 2022-10-26 | 2025-06-27 | 华能阜新风力发电有限责任公司 | 一种基于低温热解的风电叶片回收方法及其应用 |
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| US4014334A (en) * | 1976-02-02 | 1977-03-29 | Alza Corporation | Laminated osmotic system for dispensing beneficial agent |
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-
2003
- 2003-11-28 KR KR1020057010547A patent/KR20050088311A/ko not_active Ceased
- 2003-11-28 CN CNA2003801059820A patent/CN1726012A/zh active Pending
- 2003-11-28 MX MXPA05005812A patent/MXPA05005812A/es unknown
- 2003-11-28 BR BR0317275-9A patent/BR0317275A/pt not_active IP Right Cessation
- 2003-11-28 AU AU2003283688A patent/AU2003283688A1/en not_active Abandoned
- 2003-11-28 EP EP03775669A patent/EP1572163A1/en not_active Withdrawn
- 2003-11-28 NZ NZ539915A patent/NZ539915A/en unknown
- 2003-11-28 CA CA002508722A patent/CA2508722A1/en not_active Abandoned
- 2003-11-28 RU RU2005118101/15A patent/RU2308263C2/ru active
- 2003-11-28 JP JP2004558241A patent/JP2006510655A/ja not_active Withdrawn
- 2003-11-28 PL PL377479A patent/PL377479A1/pl not_active Application Discontinuation
- 2003-11-28 WO PCT/IB2003/005629 patent/WO2004052343A1/en not_active Ceased
- 2003-12-03 US US10/727,217 patent/US20040121015A1/en not_active Abandoned
- 2003-12-09 AR ARP030104525A patent/AR042340A1/es unknown
- 2003-12-10 TW TW092134835A patent/TWI257302B/zh not_active IP Right Cessation
-
2005
- 2005-05-11 ZA ZA200503812A patent/ZA200503812B/en unknown
- 2005-06-10 CO CO05056576A patent/CO5570656A2/es not_active Application Discontinuation
- 2005-06-22 NO NO20053068A patent/NO20053068L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2005118101A (ru) | 2006-01-20 |
| MXPA05005812A (es) | 2005-08-16 |
| CN1726012A (zh) | 2006-01-25 |
| AU2003283688A1 (en) | 2004-06-30 |
| TW200425888A (en) | 2004-12-01 |
| ZA200503812B (en) | 2006-07-26 |
| WO2004052343A1 (en) | 2004-06-24 |
| CO5570656A2 (es) | 2005-10-31 |
| US20040121015A1 (en) | 2004-06-24 |
| EP1572163A1 (en) | 2005-09-14 |
| JP2006510655A (ja) | 2006-03-30 |
| NO20053068D0 (no) | 2005-06-22 |
| BR0317275A (pt) | 2005-11-08 |
| RU2308263C2 (ru) | 2007-10-20 |
| KR20050088311A (ko) | 2005-09-05 |
| PL377479A1 (pl) | 2006-02-06 |
| NZ539915A (en) | 2007-09-28 |
| NO20053068L (no) | 2005-09-07 |
| TWI257302B (en) | 2006-07-01 |
| AR042340A1 (es) | 2005-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |