CA2489984A1 - Pharmaceutical compositions with improved dissolution - Google Patents

Info

Publication number

CA2489984A1

CA2489984A1 CA002489984A CA2489984A CA2489984A1 CA 2489984 A1 CA2489984 A1 CA 2489984A1 CA 002489984 A CA002489984 A CA 002489984A CA 2489984 A CA2489984 A CA 2489984A CA 2489984 A1 CA2489984 A1 CA 2489984A1

Authority

CA

Canada

Prior art keywords

celecoxib

pharmaceutical composition

pharmaceutical

excipient

salt

Prior art date

2002-06-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 238000004090 dissolution Methods 0.000 title claims abstract description 112
• 239000008194 pharmaceutical composition Substances 0.000 title claims description 124
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• 150000001875 compounds Chemical class 0.000 claims abstract description 111
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• 229960000590 celecoxib Drugs 0.000 claims description 275
• 239000000243 solution Substances 0.000 claims description 128
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• -1 alkaline earth metal salt Chemical class 0.000 claims description 86
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• 239000011734 sodium Substances 0.000 claims description 30
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 29
• 229910052708 sodium Inorganic materials 0.000 claims description 26
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 25
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