CA2489865C - Transdermal delivery rate control using amorphous pharmaceutical compositions - Google Patents
Transdermal delivery rate control using amorphous pharmaceutical compositions Download PDFInfo
- Publication number
- CA2489865C CA2489865C CA2489865A CA2489865A CA2489865C CA 2489865 C CA2489865 C CA 2489865C CA 2489865 A CA2489865 A CA 2489865A CA 2489865 A CA2489865 A CA 2489865A CA 2489865 C CA2489865 C CA 2489865C
- Authority
- CA
- Canada
- Prior art keywords
- physiologically active
- active agent
- pharmaceutical composition
- penetration enhancer
- dermal penetration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 40
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- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 65
- 231100000223 dermal penetration Toxicity 0.000 claims abstract description 62
- 239000003623 enhancer Substances 0.000 claims abstract description 48
- 239000002904 solvent Substances 0.000 claims abstract description 23
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- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 2
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- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
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- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 2
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- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- GKQPCPXONLDCMU-CCEZHUSRSA-N lacidipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C1=CC=CC=C1\C=C\C(=O)OC(C)(C)C GKQPCPXONLDCMU-CCEZHUSRSA-N 0.000 claims description 2
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
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Landscapes
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Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| US20050186141A1 (en) * | 2002-06-25 | 2005-08-25 | Acrux Dds Pty Ltd. | Transdermal aerosol compositions |
| WO2004000263A1 (en) | 2002-06-25 | 2003-12-31 | Acrux Dds Pty Ltd | Transdermal delivery rate control using amorphous pharmaceutical compositions |
| US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
| DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
| US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
| US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| DK1426049T3 (da) * | 2002-12-02 | 2005-08-22 | Sanol Arznei Schwarz Gmbh | Iontophoretisk tilförsel af rotigotin til behandling af Parkinsons sygdom |
| DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| GB0306859D0 (en) * | 2003-03-25 | 2003-04-30 | Arachnova Therapeutics Ltd | Topical formulation and use of buspirone |
| GB0319874D0 (en) * | 2003-08-22 | 2003-09-24 | Glaxo Group Ltd | Novel formulation |
| US20060263421A1 (en) | 2005-05-18 | 2006-11-23 | Abeille Pharmaceuticals Inc | Transdermal Method and Patch for Nausea |
| KR20130114229A (ko) * | 2005-06-03 | 2013-10-16 | 애크럭스 디디에스 피티와이 리미티드 | 경피 약물 전달 방법 및 조성물 |
| EP1896038B1 (en) * | 2005-06-03 | 2016-11-09 | Acrux DDS Pty Ltd | Method and composition for testosterone transdermal delivery |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| SI2089417T1 (sl) | 2006-10-12 | 2015-04-30 | Bhi Limited Partnership | Metode, spojine, sestavki in vektorji za dostavo 3-amino-1-propansulfonske kisline |
| EA015473B1 (ru) | 2007-01-11 | 2011-08-30 | АКРУКС ДиДиЭс ПиТиУай ЭлТиДи | Инструмент для нанесения объема жидкости на обрабатываемую поверхность, система и способ трансдермального введения физиологически активного вещества в организм больного |
| AR068409A1 (es) * | 2007-09-14 | 2009-11-18 | Drugtech Corp | Composiciones farmaceuticas, transdermicas sin alcohol |
| AR068408A1 (es) * | 2007-09-14 | 2009-11-18 | Drugtech Corp | Pulverizacion de hormonas transdermicas |
| KR101662186B1 (ko) * | 2007-11-02 | 2016-10-04 | 애크럭스 디디에스 피티와이 리미티드 | 경피 전달 시스템 |
| KR100929560B1 (ko) * | 2008-01-09 | 2009-12-03 | 에코 퍼시픽 엘티디 | 그라니세트론을 함유한 매트릭스 형태의 경피 흡수제 |
| US20100178307A1 (en) * | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
| JP5820469B2 (ja) | 2010-04-30 | 2015-11-24 | テイコク ファーマ ユーエスエー インコーポレーテッド | プロピニルアミノインダンの経皮組成物 |
| EP2646015B1 (en) * | 2010-12-02 | 2020-04-22 | Ferring International Center S.A. | Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate |
| CA2827435C (en) * | 2011-02-15 | 2018-11-27 | Eli Lilly And Company | Methods for controlling pain in canines using a transdermal solution of fentanyl |
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-
2003
- 2003-06-24 WO PCT/AU2003/000787 patent/WO2004000263A1/en not_active Ceased
- 2003-06-24 JP JP2004514440A patent/JP5160018B2/ja not_active Expired - Fee Related
- 2003-06-24 EA EA200500084A patent/EA009024B1/ru not_active IP Right Cessation
- 2003-06-24 CA CA2489865A patent/CA2489865C/en not_active Expired - Fee Related
- 2003-06-24 AU AU2003240301A patent/AU2003240301B2/en not_active Ceased
- 2003-06-24 KR KR1020047021362A patent/KR20050045946A/ko not_active Ceased
- 2003-06-24 EP EP03729716.5A patent/EP1534235B1/en not_active Revoked
- 2003-06-24 EP EP10010704A patent/EP2266533A3/en not_active Withdrawn
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2004
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2009
- 2009-12-18 US US12/642,301 patent/US20100166674A1/en not_active Abandoned
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2012
- 2012-04-12 JP JP2012090664A patent/JP5568108B2/ja not_active Expired - Fee Related
- 2012-12-11 US US13/710,761 patent/US8784878B2/en not_active Expired - Fee Related
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2014
- 2014-06-16 US US14/305,529 patent/US20150094290A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1534235A1 (en) | 2005-06-01 |
| BRPI0312007B1 (pt) | 2015-04-14 |
| ES2589077T3 (es) | 2016-11-10 |
| EA009024B1 (ru) | 2007-10-26 |
| US20150094290A1 (en) | 2015-04-02 |
| JP5160018B2 (ja) | 2013-03-13 |
| EP2266533A3 (en) | 2011-12-14 |
| JP2012162557A (ja) | 2012-08-30 |
| JP5568108B2 (ja) | 2014-08-06 |
| BR0312007A (pt) | 2005-04-12 |
| EP1534235A4 (en) | 2008-06-18 |
| JP2006501172A (ja) | 2006-01-12 |
| KR20050045946A (ko) | 2005-05-17 |
| US20050175680A1 (en) | 2005-08-11 |
| CA2489865A1 (en) | 2003-12-31 |
| WO2004000263A1 (en) | 2003-12-31 |
| US20130316996A1 (en) | 2013-11-28 |
| US20100166674A1 (en) | 2010-07-01 |
| HK1077192A1 (en) | 2006-02-10 |
| AU2003240301A1 (en) | 2004-01-06 |
| EP1534235B1 (en) | 2016-07-27 |
| US8784878B2 (en) | 2014-07-22 |
| EA200500084A1 (ru) | 2005-06-30 |
| AU2003240301B2 (en) | 2008-02-14 |
| KR20100055542A (ko) | 2010-05-26 |
| EP2266533A2 (en) | 2010-12-29 |
| NZ537360A (en) | 2006-09-29 |
| US8357393B2 (en) | 2013-01-22 |
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