EA200500084A1 - Фармацевтическая композиция для чрескожной доставки активного агента - Google Patents
Фармацевтическая композиция для чрескожной доставки активного агентаInfo
- Publication number
- EA200500084A1 EA200500084A1 EA200500084A EA200500084A EA200500084A1 EA 200500084 A1 EA200500084 A1 EA 200500084A1 EA 200500084 A EA200500084 A EA 200500084A EA 200500084 A EA200500084 A EA 200500084A EA 200500084 A1 EA200500084 A1 EA 200500084A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- active agent
- physiologically active
- pharmaceutical composition
- volatile solvent
- skin
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Представлена фармацевтическая композиция для чрескожной доставки, содержащая один или более физиологически активных агентов, один или более агентов, способствующих проникновению через кожу, и летучий фармацевтически приемлемый носитель, содержащий летучий растворитель, причем физиологически активный агент и агент, способствующий проникновению через кожу, образуют аморфное отложение при испарении летучего растворителя, данное аморфное отложение образует резервуар в ороговевающем слое кожи, и при этом композиция имеет такой профиль скорости высвобождения физиологически активного агента, который обеспечивает соотношение максимальной концентрации (C) и средней концентрации (C) физиологически активного агента в интервале между введениями препарата в пределах от 1 до 10.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39108102P | 2002-06-25 | 2002-06-25 | |
PCT/AU2003/000787 WO2004000263A1 (en) | 2002-06-25 | 2003-06-24 | Transdermal delivery rate control using amorphous pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500084A1 true EA200500084A1 (ru) | 2005-06-30 |
EA009024B1 EA009024B1 (ru) | 2007-10-26 |
Family
ID=30000668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500084A EA009024B1 (ru) | 2002-06-25 | 2003-06-24 | Фармацевтическая композиция для чрескожной доставки активного агента (варианты) |
Country Status (12)
Country | Link |
---|---|
US (4) | US8357393B2 (ru) |
EP (2) | EP1534235B1 (ru) |
JP (2) | JP5160018B2 (ru) |
KR (2) | KR20050045946A (ru) |
AU (1) | AU2003240301B2 (ru) |
BR (1) | BRPI0312007B1 (ru) |
CA (1) | CA2489865C (ru) |
EA (1) | EA009024B1 (ru) |
ES (1) | ES2589077T3 (ru) |
HK (1) | HK1077192A1 (ru) |
NZ (1) | NZ537360A (ru) |
WO (1) | WO2004000263A1 (ru) |
Families Citing this family (40)
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AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
US20050186141A1 (en) * | 2002-06-25 | 2005-08-25 | Acrux Dds Pty Ltd. | Transdermal aerosol compositions |
KR20050045946A (ko) | 2002-06-25 | 2005-05-17 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
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PL2219603T3 (pl) * | 2007-11-02 | 2014-10-31 | Acrux Dds Pty Ltd | Układ transdermalnego dostarczania |
KR100929560B1 (ko) * | 2008-01-09 | 2009-12-03 | 에코 퍼시픽 엘티디 | 그라니세트론을 함유한 매트릭스 형태의 경피 흡수제 |
US20100178307A1 (en) * | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
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CN103930105B (zh) * | 2010-12-02 | 2019-11-01 | 尼克美控股公司 | 2-(n,n-二甲基氨基)-丙酸十二烷基酯的活性对映体 |
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-
2003
- 2003-06-24 KR KR1020047021362A patent/KR20050045946A/ko not_active Application Discontinuation
- 2003-06-24 BR BRPI0312007-4A patent/BRPI0312007B1/pt not_active IP Right Cessation
- 2003-06-24 EA EA200500084A patent/EA009024B1/ru not_active IP Right Cessation
- 2003-06-24 WO PCT/AU2003/000787 patent/WO2004000263A1/en active Application Filing
- 2003-06-24 KR KR1020107009520A patent/KR20100055542A/ko active Search and Examination
- 2003-06-24 EP EP03729716.5A patent/EP1534235B1/en not_active Revoked
- 2003-06-24 CA CA2489865A patent/CA2489865C/en not_active Expired - Fee Related
- 2003-06-24 EP EP10010704A patent/EP2266533A3/en not_active Withdrawn
- 2003-06-24 JP JP2004514440A patent/JP5160018B2/ja not_active Expired - Fee Related
- 2003-06-24 NZ NZ537360A patent/NZ537360A/en not_active IP Right Cessation
- 2003-06-24 ES ES03729716.5T patent/ES2589077T3/es not_active Expired - Lifetime
- 2003-06-24 AU AU2003240301A patent/AU2003240301B2/en not_active Ceased
-
2004
- 2004-12-07 US US11/004,926 patent/US8357393B2/en not_active Expired - Fee Related
-
2005
- 2005-10-14 HK HK05109101.2A patent/HK1077192A1/zh not_active IP Right Cessation
-
2009
- 2009-12-18 US US12/642,301 patent/US20100166674A1/en not_active Abandoned
-
2012
- 2012-04-12 JP JP2012090664A patent/JP5568108B2/ja not_active Expired - Fee Related
- 2012-12-11 US US13/710,761 patent/US8784878B2/en not_active Expired - Fee Related
-
2014
- 2014-06-16 US US14/305,529 patent/US20150094290A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2266533A3 (en) | 2011-12-14 |
JP5160018B2 (ja) | 2013-03-13 |
JP2006501172A (ja) | 2006-01-12 |
EP2266533A2 (en) | 2010-12-29 |
EP1534235A4 (en) | 2008-06-18 |
KR20050045946A (ko) | 2005-05-17 |
JP2012162557A (ja) | 2012-08-30 |
US8784878B2 (en) | 2014-07-22 |
EA009024B1 (ru) | 2007-10-26 |
JP5568108B2 (ja) | 2014-08-06 |
HK1077192A1 (zh) | 2006-02-10 |
EP1534235A1 (en) | 2005-06-01 |
US8357393B2 (en) | 2013-01-22 |
US20130316996A1 (en) | 2013-11-28 |
NZ537360A (en) | 2006-09-29 |
CA2489865A1 (en) | 2003-12-31 |
WO2004000263A1 (en) | 2003-12-31 |
KR20100055542A (ko) | 2010-05-26 |
AU2003240301A1 (en) | 2004-01-06 |
CA2489865C (en) | 2012-05-08 |
US20050175680A1 (en) | 2005-08-11 |
AU2003240301B2 (en) | 2008-02-14 |
US20100166674A1 (en) | 2010-07-01 |
ES2589077T3 (es) | 2016-11-10 |
BRPI0312007B1 (pt) | 2015-04-14 |
EP1534235B1 (en) | 2016-07-27 |
BR0312007A (pt) | 2005-04-12 |
US20150094290A1 (en) | 2015-04-02 |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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