CA2487679A1 - Inhibitors of jak and cdk2 protein kinases - Google Patents
Inhibitors of jak and cdk2 protein kinases Download PDFInfo
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- CA2487679A1 CA2487679A1 CA002487679A CA2487679A CA2487679A1 CA 2487679 A1 CA2487679 A1 CA 2487679A1 CA 002487679 A CA002487679 A CA 002487679A CA 2487679 A CA2487679 A CA 2487679A CA 2487679 A1 CA2487679 A1 CA 2487679A1
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US38453802P | 2002-05-30 | 2002-05-30 | |
| US60/384,538 | 2002-05-30 | ||
| PCT/US2003/016900 WO2003101989A1 (en) | 2002-05-30 | 2003-05-30 | Inhibitors of jak and cdk2 protein kinases |
Publications (1)
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| CA2487679A1 true CA2487679A1 (en) | 2003-12-11 |
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| CA002487679A Abandoned CA2487679A1 (en) | 2002-05-30 | 2003-05-30 | Inhibitors of jak and cdk2 protein kinases |
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| US (1) | US7122552B2 (enExample) |
| EP (1) | EP1507779A1 (enExample) |
| JP (2) | JP2005528443A (enExample) |
| KR (1) | KR20050013562A (enExample) |
| CN (1) | CN1665810A (enExample) |
| AU (1) | AU2003231880A1 (enExample) |
| CA (1) | CA2487679A1 (enExample) |
| MX (1) | MXPA04011956A (enExample) |
| NO (1) | NO20045677L (enExample) |
| PL (1) | PL374023A1 (enExample) |
| RU (1) | RU2004138819A (enExample) |
| WO (1) | WO2003101989A1 (enExample) |
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| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN103169708B (zh) | 2002-07-29 | 2018-02-02 | 里格尔药品股份有限公司 | 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| JP4886511B2 (ja) | 2003-07-30 | 2012-02-29 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法 |
| AU2011253635B2 (en) * | 2003-09-17 | 2014-10-30 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
| KR101151653B1 (ko) * | 2003-09-17 | 2012-06-28 | 얀센 파마슈티카 엔.브이. | 융합된 헤테로사이클릭 화합물 |
| WO2005068473A1 (en) * | 2003-12-17 | 2005-07-28 | Sgx Pharmaceuticals, Inc. | Bicyclic pyrazolo-fused compounds as protein kinase modulators |
| WO2005123111A2 (en) * | 2004-06-21 | 2005-12-29 | Exelixis, Inc. | Maxs as modifiers of the axin pathway and methods of use |
| CA2581623A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| ES2337496T3 (es) * | 2005-01-19 | 2010-04-26 | Rigel Pharmaceuticals, Inc. | Profarmacos de compuestos de 2,4-pirimidindiamina y sus usos. |
| US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| JP5225079B2 (ja) | 2005-06-08 | 2013-07-03 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋ経路の阻害のための組成物および方法 |
| US8962643B2 (en) * | 2006-02-24 | 2015-02-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| CA2650140A1 (en) | 2006-04-14 | 2007-10-25 | Mriganka Sur | Identifying and modulating molecular pathways that mediate nervous system plasticity |
| JP4960450B2 (ja) * | 2006-07-14 | 2012-06-27 | ノバルティス アーゲー | Ａｌｋ−５阻害剤としてのピリミジン誘導体 |
| KR20090082453A (ko) * | 2006-11-01 | 2009-07-30 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물 |
| WO2008135786A1 (en) * | 2007-05-04 | 2008-11-13 | Astrazeneca Ab | Amino-thiazolyl- pyrimidine derivatives and their use for the treatment of cancer |
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| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
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| JP5063815B2 (ja) * | 2008-11-25 | 2012-10-31 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 抗腫瘍および抗神経変性剤としての二環式ピラゾールおよびイソオキサゾール誘導体 |
| EP2396004A4 (en) * | 2009-02-11 | 2012-07-25 | Reaction Biology Corp | SELECTIVE KINASE HEMMER |
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| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
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| HRP20181976T1 (hr) * | 2012-03-29 | 2019-01-25 | The Trustees Of Columbia University In The City Of New York | Postupci za liječenje poremećaja gubitka kose |
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| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
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| US10759865B2 (en) | 2017-08-22 | 2020-09-01 | Eyal Levit | Treatment of diabetes mellitus |
| WO2019046316A1 (en) * | 2017-08-28 | 2019-03-07 | Acurastem Inc. | PIKFYVE KINASE INHIBITORS |
| CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
| MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
| EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP3955920A1 (en) | 2019-04-16 | 2022-02-23 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN114605390B (zh) * | 2020-12-04 | 2024-08-16 | 上海凌达生物医药有限公司 | 具有cdk激酶抑制活性的化合物、其药物组合物和用途 |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
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| DK27383A (da) | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
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2003
- 2003-05-30 EP EP03756252A patent/EP1507779A1/en not_active Ceased
- 2003-05-30 WO PCT/US2003/016900 patent/WO2003101989A1/en not_active Ceased
- 2003-05-30 CN CN038159589A patent/CN1665810A/zh active Pending
- 2003-05-30 US US10/449,742 patent/US7122552B2/en not_active Expired - Fee Related
- 2003-05-30 MX MXPA04011956A patent/MXPA04011956A/es unknown
- 2003-05-30 KR KR10-2004-7019397A patent/KR20050013562A/ko not_active Withdrawn
- 2003-05-30 PL PL03374023A patent/PL374023A1/xx not_active Application Discontinuation
- 2003-05-30 RU RU2004138819/04A patent/RU2004138819A/ru not_active Application Discontinuation
- 2003-05-30 CA CA002487679A patent/CA2487679A1/en not_active Abandoned
- 2003-05-30 JP JP2004509680A patent/JP2005528443A/ja active Pending
- 2003-05-30 AU AU2003231880A patent/AU2003231880A1/en not_active Withdrawn
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2004
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| US7122552B2 (en) | 2006-10-17 |
| JP2011006494A (ja) | 2011-01-13 |
| NO20045677L (no) | 2005-02-28 |
| WO2003101989A1 (en) | 2003-12-11 |
| NO20045677D0 (no) | 2004-12-28 |
| AU2003231880A1 (en) | 2003-12-19 |
| RU2004138819A (ru) | 2005-06-10 |
| PL374023A1 (en) | 2005-09-19 |
| MXPA04011956A (es) | 2005-03-31 |
| CN1665810A (zh) | 2005-09-07 |
| EP1507779A1 (en) | 2005-02-23 |
| JP2005528443A (ja) | 2005-09-22 |
| US20030236244A1 (en) | 2003-12-25 |
| KR20050013562A (ko) | 2005-02-04 |
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