CA2487679A1 - Inhibitors of jak and cdk2 protein kinases - Google Patents
Inhibitors of jak and cdk2 protein kinases Download PDFInfo
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- CA2487679A1 CA2487679A1 CA002487679A CA2487679A CA2487679A1 CA 2487679 A1 CA2487679 A1 CA 2487679A1 CA 002487679 A CA002487679 A CA 002487679A CA 2487679 A CA2487679 A CA 2487679A CA 2487679 A1 CA2487679 A1 CA 2487679A1
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Landscapes
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- Neurosurgery (AREA)
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- Virology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38453802P | 2002-05-30 | 2002-05-30 | |
| US60/384,538 | 2002-05-30 | ||
| PCT/US2003/016900 WO2003101989A1 (en) | 2002-05-30 | 2003-05-30 | Inhibitors of jak and cdk2 protein kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2487679A1 true CA2487679A1 (en) | 2003-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002487679A Abandoned CA2487679A1 (en) | 2002-05-30 | 2003-05-30 | Inhibitors of jak and cdk2 protein kinases |
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|---|---|
| US (1) | US7122552B2 (enExample) |
| EP (1) | EP1507779A1 (enExample) |
| JP (2) | JP2005528443A (enExample) |
| KR (1) | KR20050013562A (enExample) |
| CN (1) | CN1665810A (enExample) |
| AU (1) | AU2003231880A1 (enExample) |
| CA (1) | CA2487679A1 (enExample) |
| MX (1) | MXPA04011956A (enExample) |
| NO (1) | NO20045677L (enExample) |
| PL (1) | PL374023A1 (enExample) |
| RU (1) | RU2004138819A (enExample) |
| WO (1) | WO2003101989A1 (enExample) |
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| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| BR0313059B8 (pt) | 2002-07-29 | 2021-07-27 | Rigel Pharmaceuticals | composto, e, composição farmacêutica |
| CN102358738A (zh) | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| AU2011253635B2 (en) * | 2003-09-17 | 2014-10-30 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
| DE602004019118D1 (de) | 2003-09-17 | 2009-03-05 | Janssen Pharmaceutica Nv | Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors |
| WO2005068473A1 (en) * | 2003-12-17 | 2005-07-28 | Sgx Pharmaceuticals, Inc. | Bicyclic pyrazolo-fused compounds as protein kinase modulators |
| WO2005123111A2 (en) * | 2004-06-21 | 2005-12-29 | Exelixis, Inc. | Maxs as modifiers of the axin pathway and methods of use |
| CA2581623A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| JP4801096B2 (ja) * | 2005-01-19 | 2011-10-26 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物のプロドラッグおよびそれらの使用 |
| US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP1904457B1 (en) | 2005-06-08 | 2017-09-06 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2008079521A2 (en) * | 2006-11-01 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | Tricyclic heteroaryl compounds useful as inhibitors of janus kinase |
| JP2009528295A (ja) | 2006-02-24 | 2009-08-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋ経路の阻害のための組成物および方法 |
| US8969295B2 (en) * | 2006-04-14 | 2015-03-03 | Massachusetts Institute Of Technology | Identifying and modulating molecular pathways that mediate nervous system plasticity |
| EP2044056B1 (en) * | 2006-07-14 | 2012-08-22 | Novartis AG | Pyrimidine derivatives as alk-5 inhibitors |
| US20100137398A1 (en) * | 2007-05-04 | 2010-06-03 | Novartis Ag | Use of hdac inhibitors for the treatment of gastrointestinal cancers |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| MX2010011463A (es) | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas. |
| JP2011518219A (ja) | 2008-04-22 | 2011-06-23 | ポートラ ファーマシューティカルズ， インコーポレイテッド | タンパク質キナーゼの阻害剤 |
| JP5063815B2 (ja) * | 2008-11-25 | 2012-10-31 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 抗腫瘍および抗神経変性剤としての二環式ピラゾールおよびイソオキサゾール誘導体 |
| JP2012517448A (ja) * | 2009-02-11 | 2012-08-02 | リアクション バイオロジー コープ． | 選択的キナーゼ阻害剤 |
| US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| JO3030B1 (ar) * | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
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| CA2768543C (en) * | 2009-07-28 | 2017-06-20 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| JP2013503189A (ja) * | 2009-08-28 | 2013-01-31 | アレイ バイオファーマ、インコーポレイテッド | Ｒａｆ阻害化合物およびその使用方法 |
| UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| EP2635557A2 (en) | 2010-11-01 | 2013-09-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| SG11201402570QA (en) | 2011-11-23 | 2014-06-27 | Portola Pharm Inc | Pyrazine kinase inhibitors |
| WO2013113762A1 (en) | 2012-01-31 | 2013-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cutaneous melanoma in a subject |
| ES2694681T3 (es) * | 2012-03-29 | 2018-12-26 | The Trustees Of Columbia University In The City Of New York | Métodos para tratar trastornos de pérdida capilar |
| SI3459942T1 (sl) | 2012-04-24 | 2021-05-31 | Vertex Pharmaceuticals Incorporated | Inhibitorji DNA-PK |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| US9676756B2 (en) | 2012-10-08 | 2017-06-13 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| HUE041544T2 (hu) | 2013-03-12 | 2019-05-28 | Vertex Pharma | DNS-PK inhibitorok |
| PT3424920T (pt) | 2013-10-17 | 2020-07-07 | Vertex Pharma | Co-cristais de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolina-4-carboxamida e derivados deuterados dos mesmos como inibidores de adn-pk |
| RU2016141934A (ru) * | 2014-04-04 | 2018-05-07 | Сирос Фармасьютикалз, Инк. | Ингибиторы циклин-зависимой киназы 7 (cdk7) |
| US9527845B2 (en) * | 2014-12-30 | 2016-12-27 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis B infections |
| US10045981B2 (en) | 2015-11-24 | 2018-08-14 | Jakpharm, Llc | Selective kinase inhibitors |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| JP2019529475A (ja) | 2016-09-27 | 2019-10-17 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｄｎａ損傷剤とｄｎａ−ｐｋ阻害剤との組合せ物を使用する、がんを処置するための方法 |
| US10759865B2 (en) | 2017-08-22 | 2020-09-01 | Eyal Levit | Treatment of diabetes mellitus |
| WO2019046316A1 (en) * | 2017-08-28 | 2019-03-07 | Acurastem Inc. | PIKFYVE KINASE INHIBITORS |
| CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| US20220202820A1 (en) | 2019-04-16 | 2022-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN114605390B (zh) * | 2020-12-04 | 2024-08-16 | 上海凌达生物医药有限公司 | 具有cdk激酶抑制活性的化合物、其药物组合物和用途 |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| EP4526469A1 (en) | 2022-05-16 | 2025-03-26 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
| WO2026024674A1 (en) | 2024-07-22 | 2026-01-29 | Genesis Therapeutics, Inc. | Methods of treating skp2-associated cancers |
| WO2026093435A1 (en) | 2024-10-31 | 2026-05-07 | Institut National de la Santé et de la Recherche Médicale | Use of jak inhibitors for enhancing the potency of immunotherapy in the treament of cancer |
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|---|---|---|---|---|
| DK27383A (da) * | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
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2003
- 2003-05-30 AU AU2003231880A patent/AU2003231880A1/en not_active Withdrawn
- 2003-05-30 US US10/449,742 patent/US7122552B2/en not_active Expired - Fee Related
- 2003-05-30 MX MXPA04011956A patent/MXPA04011956A/es unknown
- 2003-05-30 KR KR10-2004-7019397A patent/KR20050013562A/ko not_active Withdrawn
- 2003-05-30 EP EP03756252A patent/EP1507779A1/en not_active Ceased
- 2003-05-30 PL PL03374023A patent/PL374023A1/xx not_active Application Discontinuation
- 2003-05-30 WO PCT/US2003/016900 patent/WO2003101989A1/en not_active Ceased
- 2003-05-30 CA CA002487679A patent/CA2487679A1/en not_active Abandoned
- 2003-05-30 CN CN038159589A patent/CN1665810A/zh active Pending
- 2003-05-30 RU RU2004138819/04A patent/RU2004138819A/ru not_active Application Discontinuation
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2004
- 2004-12-28 NO NO20045677A patent/NO20045677L/no not_active Application Discontinuation
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04011956A (es) | 2005-03-31 |
| JP2005528443A (ja) | 2005-09-22 |
| PL374023A1 (en) | 2005-09-19 |
| CN1665810A (zh) | 2005-09-07 |
| RU2004138819A (ru) | 2005-06-10 |
| EP1507779A1 (en) | 2005-02-23 |
| WO2003101989A1 (en) | 2003-12-11 |
| US20030236244A1 (en) | 2003-12-25 |
| NO20045677D0 (no) | 2004-12-28 |
| JP2011006494A (ja) | 2011-01-13 |
| US7122552B2 (en) | 2006-10-17 |
| AU2003231880A1 (en) | 2003-12-19 |
| NO20045677L (no) | 2005-02-28 |
| KR20050013562A (ko) | 2005-02-04 |
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