AU2003231880A1 - Inhibitors of jak and cdk2 protein kinases - Google Patents
Inhibitors of jak and cdk2 protein kinases Download PDFInfo
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- AU2003231880A1 AU2003231880A1 AU2003231880A AU2003231880A AU2003231880A1 AU 2003231880 A1 AU2003231880 A1 AU 2003231880A1 AU 2003231880 A AU2003231880 A AU 2003231880A AU 2003231880 A AU2003231880 A AU 2003231880A AU 2003231880 A1 AU2003231880 A1 AU 2003231880A1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US38453802P | 2002-05-30 | 2002-05-30 | |
| US60/384,538 | 2002-05-30 | ||
| PCT/US2003/016900 WO2003101989A1 (en) | 2002-05-30 | 2003-05-30 | Inhibitors of jak and cdk2 protein kinases |
Publications (1)
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| AU2003231880A1 true AU2003231880A1 (en) | 2003-12-19 |
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| US (1) | US7122552B2 (enExample) |
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| PL (1) | PL374023A1 (enExample) |
| RU (1) | RU2004138819A (enExample) |
| WO (1) | WO2003101989A1 (enExample) |
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| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| IL166241A0 (en) | 2002-07-29 | 2006-01-15 | Rigel Pharmaceuticals Inc | Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds |
| US8178671B2 (en) | 2003-07-30 | 2012-05-15 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds |
| AU2011253635B2 (en) * | 2003-09-17 | 2014-10-30 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
| WO2005040169A2 (en) * | 2003-09-17 | 2005-05-06 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as serotonin receptor modulators |
| US7473783B2 (en) | 2003-12-17 | 2009-01-06 | Sgx Pharmaceuticals, Inc. | Bicyclic pyrazolo protein kinase modulators |
| WO2005123111A2 (en) * | 2004-06-21 | 2005-12-29 | Exelixis, Inc. | Maxs as modifiers of the axin pathway and methods of use |
| CA2581454A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyrimidine compounds, process for their preparation and compositions containing them |
| EP1856135B1 (en) | 2005-01-19 | 2009-12-09 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| CN105348203B (zh) | 2005-06-08 | 2018-09-18 | 里格尔药品股份有限公司 | 抑制jak途径的组合物和方法 |
| US8962643B2 (en) * | 2006-02-24 | 2015-02-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| CA2650140A1 (en) * | 2006-04-14 | 2007-10-25 | Mriganka Sur | Identifying and modulating molecular pathways that mediate nervous system plasticity |
| EP2044056B1 (en) * | 2006-07-14 | 2012-08-22 | Novartis AG | Pyrimidine derivatives as alk-5 inhibitors |
| CA2668159A1 (en) * | 2006-11-01 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | Tricyclic heteroaryl compounds useful as inhibitors of janus kinase |
| US20100137398A1 (en) * | 2007-05-04 | 2010-06-03 | Novartis Ag | Use of hdac inhibitors for the treatment of gastrointestinal cancers |
| LT2265607T (lt) * | 2008-02-15 | 2017-03-27 | Rigel Pharmaceuticals, Inc. | Pirimidin-2-amino junginiai ir jų panaudojimas kaip jak kinazių slopiklių |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| WO2009131687A2 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| JP5063815B2 (ja) * | 2008-11-25 | 2012-10-31 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 抗腫瘍および抗神経変性剤としての二環式ピラゾールおよびイソオキサゾール誘導体 |
| WO2010093808A1 (en) * | 2009-02-11 | 2010-08-19 | Reaction Biology Corp. | Selective kinase inhibitors |
| US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| JO3030B1 (ar) * | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| WO2011008915A1 (en) * | 2009-07-15 | 2011-01-20 | Abbott Laboratories | Pyrrolopyridine inhibitors of kinases |
| WO2011017178A1 (en) * | 2009-07-28 | 2011-02-10 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2011025947A1 (en) * | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| JP6039683B2 (ja) | 2011-11-23 | 2016-12-07 | ポートラ ファーマシューティカルズ， インコーポレイテッド | ピラジンキナーゼ阻害剤 |
| WO2013113762A1 (en) | 2012-01-31 | 2013-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cutaneous melanoma in a subject |
| CN104334191A (zh) * | 2012-03-29 | 2015-02-04 | 纽约市哥伦比亚大学托管会 | 治疗毛发脱落疾病的方法 |
| SMT201800608T1 (it) | 2012-04-24 | 2019-01-11 | Vertex Pharma | Inibitori di dna-pk |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| EP2903970A4 (en) | 2012-10-08 | 2016-11-30 | Portola Pharm Inc | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS |
| AU2014244555B2 (en) | 2013-03-12 | 2018-06-28 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
| HUE041877T2 (hu) | 2013-10-17 | 2019-06-28 | Vertex Pharma | (S)-N-Metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propán-2-il)kinolin-4-karboxamid kokristályai és deuterált származékai DNS-PK inhibitorokként |
| DK3126352T3 (en) * | 2014-04-04 | 2019-01-21 | Syros Pharmaceuticals Inc | CYCLINE INDEPENDENT KINASE 7 INHIBITORS (CDK7) |
| US9550779B2 (en) * | 2014-12-30 | 2017-01-24 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis B infections |
| WO2017091681A1 (en) | 2015-11-24 | 2017-06-01 | Aclaris Therapeutics, Inc. | Selective kinase inhibitors |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| US11110108B2 (en) | 2016-09-27 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
| US10759865B2 (en) | 2017-08-22 | 2020-09-01 | Eyal Levit | Treatment of diabetes mellitus |
| WO2019046316A1 (en) * | 2017-08-28 | 2019-03-07 | Acurastem Inc. | PIKFYVE KINASE INHIBITORS |
| CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020212395A1 (en) | 2019-04-16 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN114605390B (zh) * | 2020-12-04 | 2024-08-16 | 上海凌达生物医药有限公司 | 具有cdk激酶抑制活性的化合物、其药物组合物和用途 |
| US12097261B2 (en) | 2021-05-07 | 2024-09-24 | Kymera Therapeutics, Inc. | CDK2 degraders and uses thereof |
| US20250283174A1 (en) | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
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| DK27383A (da) * | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
| GB0016877D0 (en) * | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
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2003
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- 2003-05-30 JP JP2004509680A patent/JP2005528443A/ja active Pending
- 2003-05-30 MX MXPA04011956A patent/MXPA04011956A/es unknown
- 2003-05-30 PL PL03374023A patent/PL374023A1/xx not_active Application Discontinuation
- 2003-05-30 KR KR10-2004-7019397A patent/KR20050013562A/ko not_active Withdrawn
- 2003-05-30 EP EP03756252A patent/EP1507779A1/en not_active Ceased
- 2003-05-30 US US10/449,742 patent/US7122552B2/en not_active Expired - Fee Related
- 2003-05-30 AU AU2003231880A patent/AU2003231880A1/en not_active Withdrawn
- 2003-05-30 CN CN038159589A patent/CN1665810A/zh active Pending
- 2003-05-30 CA CA002487679A patent/CA2487679A1/en not_active Abandoned
- 2003-05-30 RU RU2004138819/04A patent/RU2004138819A/ru not_active Application Discontinuation
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2010
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| MXPA04011956A (es) | 2005-03-31 |
| WO2003101989A1 (en) | 2003-12-11 |
| US20030236244A1 (en) | 2003-12-25 |
| RU2004138819A (ru) | 2005-06-10 |
| PL374023A1 (en) | 2005-09-19 |
| CN1665810A (zh) | 2005-09-07 |
| CA2487679A1 (en) | 2003-12-11 |
| EP1507779A1 (en) | 2005-02-23 |
| US7122552B2 (en) | 2006-10-17 |
| JP2005528443A (ja) | 2005-09-22 |
| NO20045677L (no) | 2005-02-28 |
| JP2011006494A (ja) | 2011-01-13 |
| KR20050013562A (ko) | 2005-02-04 |
| NO20045677D0 (no) | 2004-12-28 |
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| MK12 | Application lapsed section 141(1)/reg 8.3(2) - applicant filed a written notice of withdrawal |