NO20045677D0 - Inhibitorer av JAK- og CDK2-proteinkinaser - Google Patents
Inhibitorer av JAK- og CDK2-proteinkinaserInfo
- Publication number
- NO20045677D0 NO20045677D0 NO20045677A NO20045677A NO20045677D0 NO 20045677 D0 NO20045677 D0 NO 20045677D0 NO 20045677 A NO20045677 A NO 20045677A NO 20045677 A NO20045677 A NO 20045677A NO 20045677 D0 NO20045677 D0 NO 20045677D0
- Authority
- NO
- Norway
- Prior art keywords
- jak
- inhibitors
- protein kinases
- cdk2 protein
- cdk2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38453802P | 2002-05-30 | 2002-05-30 | |
PCT/US2003/016900 WO2003101989A1 (en) | 2002-05-30 | 2003-05-30 | Inhibitors of jak and cdk2 protein kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20045677D0 true NO20045677D0 (no) | 2004-12-28 |
NO20045677L NO20045677L (no) | 2005-02-28 |
Family
ID=29712051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20045677A NO20045677L (no) | 2002-05-30 | 2004-12-28 | Inhibitorer av JAK- og CDK2-proteinkinaser |
Country Status (12)
Country | Link |
---|---|
US (1) | US7122552B2 (no) |
EP (1) | EP1507779A1 (no) |
JP (2) | JP2005528443A (no) |
KR (1) | KR20050013562A (no) |
CN (1) | CN1665810A (no) |
AU (1) | AU2003231880A1 (no) |
CA (1) | CA2487679A1 (no) |
MX (1) | MXPA04011956A (no) |
NO (1) | NO20045677L (no) |
PL (1) | PL374023A1 (no) |
RU (1) | RU2004138819A (no) |
WO (1) | WO2003101989A1 (no) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
EP1534286B1 (en) | 2002-07-29 | 2009-12-09 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
CN1849318B (zh) * | 2003-07-30 | 2011-10-12 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物预防和治疗自体免疫疾病的方法 |
CN103788089A (zh) | 2003-09-17 | 2014-05-14 | 詹森药业有限公司 | 作为血清素受体调节剂的稠合杂环化合物 |
AU2011253635B2 (en) * | 2003-09-17 | 2014-10-30 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
AU2004313947B2 (en) * | 2003-12-17 | 2011-03-31 | Sgx Pharmaceuticals, Inc. | Bicyclic pyrazolo-fused compounds as protein kinase modulators |
WO2005123111A2 (en) * | 2004-06-21 | 2005-12-29 | Exelixis, Inc. | Maxs as modifiers of the axin pathway and methods of use |
DE602006010979D1 (de) | 2005-01-19 | 2010-01-21 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
US7491732B2 (en) | 2005-06-08 | 2009-02-17 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
CA2642229C (en) | 2006-02-24 | 2015-05-12 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
JP2009533458A (ja) * | 2006-04-14 | 2009-09-17 | マサチューセッツ インスティテュート オブ テクノロジー | 神経系の可塑性を媒介する分子経路の同定および変調 |
CA2657227A1 (en) * | 2006-07-14 | 2008-01-17 | Novartis Ag | Pyrimidine derivatives as alk-5 inhibitors |
MX2009004771A (es) * | 2006-11-01 | 2009-06-17 | Vertex Pharma | Compuestos heteroaril triciclicos utiles como inhibidores de janus cinasa. |
CN101687863B (zh) * | 2007-05-04 | 2012-09-12 | 阿斯利康(瑞典)有限公司 | 氨基-噻唑基-嘧啶衍生物及其治疗癌症的用途 |
PT2265607T (pt) | 2008-02-15 | 2017-03-08 | Rigel Pharmaceuticals Inc | Compostos de pirimidina-2-amina e sua utilização como inibidores de jak cinases |
ES2546502T3 (es) | 2008-04-16 | 2015-09-24 | Portola Pharmaceuticals, Inc. | 2,6-Diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o JAK quinasas |
US8138339B2 (en) * | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
AU2009238590A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
JP5063815B2 (ja) * | 2008-11-25 | 2012-10-31 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 抗腫瘍および抗神経変性剤としての二環式ピラゾールおよびイソオキサゾール誘導体 |
US8592415B2 (en) * | 2009-02-11 | 2013-11-26 | Reaction Biology Corp. | Selective kinase inhibitors |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
JO3030B1 (ar) * | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
MX2012000709A (es) * | 2009-07-15 | 2012-03-16 | Abbott Lab | Inhibidores de pirrolopiridina de cinasas. |
RU2557982C2 (ru) * | 2009-07-28 | 2015-07-27 | Райджел Фармасьютикалз, Инк. | Композиции и способы ингибирования пути jak |
CA2771893A1 (en) * | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
TW201300360A (zh) | 2010-11-01 | 2013-01-01 | Portola Pharm Inc | 做為jak激酶調節劑之菸鹼醯胺 |
US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
WO2013149194A1 (en) * | 2012-03-29 | 2013-10-03 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
US9359308B2 (en) | 2011-11-23 | 2016-06-07 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
WO2013113762A1 (en) | 2012-01-31 | 2013-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cutaneous melanoma in a subject |
RS61664B1 (sr) | 2012-04-24 | 2021-04-29 | Vertex Pharma | Inhibitori dna-pk |
WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
HUE041544T2 (hu) | 2013-03-12 | 2019-05-28 | Vertex Pharma | DNS-PK inhibitorok |
PT3424920T (pt) | 2013-10-17 | 2020-07-07 | Vertex Pharma | Co-cristais de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolina-4-carboxamida e derivados deuterados dos mesmos como inibidores de adn-pk |
CN110229142A (zh) * | 2014-04-04 | 2019-09-13 | 希洛斯医药品股份有限公司 | 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂 |
KR20170118706A (ko) * | 2014-12-30 | 2017-10-25 | 노비라 테라퓨틱스, 인코포레이티드 | B형 간염 감염을 치료하는 유도체 및 그 방법 |
US10045981B2 (en) | 2015-11-24 | 2018-08-14 | Jakpharm, Llc | Selective kinase inhibitors |
WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
CA3038657A1 (en) | 2016-09-27 | 2018-04-05 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors |
US10759865B2 (en) | 2017-08-22 | 2020-09-01 | Eyal Levit | Treatment of diabetes mellitus |
US20200199136A1 (en) * | 2017-08-28 | 2020-06-25 | Acurastem Inc. | Pikfyve kinase inhibitors |
CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
WO2020212395A1 (en) | 2019-04-16 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN114605390B (zh) * | 2020-12-04 | 2024-08-16 | 上海凌达生物医药有限公司 | 具有cdk激酶抑制活性的化合物、其药物组合物和用途 |
WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK27383A (da) * | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
GB0016877D0 (en) * | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
-
2003
- 2003-05-30 EP EP03756252A patent/EP1507779A1/en not_active Ceased
- 2003-05-30 JP JP2004509680A patent/JP2005528443A/ja active Pending
- 2003-05-30 PL PL03374023A patent/PL374023A1/xx not_active Application Discontinuation
- 2003-05-30 MX MXPA04011956A patent/MXPA04011956A/es unknown
- 2003-05-30 US US10/449,742 patent/US7122552B2/en not_active Expired - Fee Related
- 2003-05-30 KR KR10-2004-7019397A patent/KR20050013562A/ko not_active Application Discontinuation
- 2003-05-30 WO PCT/US2003/016900 patent/WO2003101989A1/en active Application Filing
- 2003-05-30 CN CN038159589A patent/CN1665810A/zh active Pending
- 2003-05-30 CA CA002487679A patent/CA2487679A1/en not_active Abandoned
- 2003-05-30 AU AU2003231880A patent/AU2003231880A1/en not_active Withdrawn
- 2003-05-30 RU RU2004138819/04A patent/RU2004138819A/ru not_active Application Discontinuation
-
2004
- 2004-12-28 NO NO20045677A patent/NO20045677L/no not_active Application Discontinuation
-
2010
- 2010-10-15 JP JP2010233088A patent/JP2011006494A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2004138819A (ru) | 2005-06-10 |
MXPA04011956A (es) | 2005-03-31 |
CA2487679A1 (en) | 2003-12-11 |
CN1665810A (zh) | 2005-09-07 |
US20030236244A1 (en) | 2003-12-25 |
WO2003101989A1 (en) | 2003-12-11 |
EP1507779A1 (en) | 2005-02-23 |
AU2003231880A1 (en) | 2003-12-19 |
JP2011006494A (ja) | 2011-01-13 |
US7122552B2 (en) | 2006-10-17 |
KR20050013562A (ko) | 2005-02-04 |
NO20045677L (no) | 2005-02-28 |
JP2005528443A (ja) | 2005-09-22 |
PL374023A1 (en) | 2005-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |