CA2466130A1 - Systems and methods for freezing and storing biopharmaceutical material - Google Patents
Systems and methods for freezing and storing biopharmaceutical material Download PDFInfo
- Publication number
- CA2466130A1 CA2466130A1 CA002466130A CA2466130A CA2466130A1 CA 2466130 A1 CA2466130 A1 CA 2466130A1 CA 002466130 A CA002466130 A CA 002466130A CA 2466130 A CA2466130 A CA 2466130A CA 2466130 A1 CA2466130 A1 CA 2466130A1
- Authority
- CA
- Canada
- Prior art keywords
- container
- control unit
- temperature control
- biopharmaceutical material
- biopharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000463 material Substances 0.000 title claims abstract description 183
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 170
- 238000007710 freezing Methods 0.000 title claims abstract description 87
- 230000008014 freezing Effects 0.000 title claims abstract description 87
- 238000000034 method Methods 0.000 title claims description 29
- 238000012546 transfer Methods 0.000 claims abstract description 56
- 238000010257 thawing Methods 0.000 claims abstract description 34
- 239000012530 fluid Substances 0.000 claims abstract description 11
- 238000004891 communication Methods 0.000 claims abstract description 4
- 230000004044 response Effects 0.000 claims description 7
- 238000005304 joining Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 239000013078 crystal Substances 0.000 description 21
- 210000001787 dendrite Anatomy 0.000 description 14
- 239000007788 liquid Substances 0.000 description 14
- 238000001816 cooling Methods 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- 230000001105 regulatory effect Effects 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 7
- 239000007791 liquid phase Substances 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- -1 polypropylene Polymers 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 239000004952 Polyamide Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000005138 cryopreservation Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000001627 detrimental effect Effects 0.000 description 3
- 230000005496 eutectics Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000004781 supercooling Methods 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 239000004708 Very-low-density polyethylene Substances 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000009828 non-uniform distribution Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229920001866 very low density polyethylene Polymers 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D31/00—Other cooling or freezing apparatus
- F25D31/001—Plate freezers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
- A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/80—Freezing; Subsequent thawing; Cooling
- A23B2/805—Materials not being transported through or in the apparatus with or without shaping, e.g. in the form of powders, granules or flakes
- A23B2/8055—Materials not being transported through or in the apparatus with or without shaping, e.g. in the form of powders, granules or flakes with packages or with shaping in the form of blocks or portions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/80—Freezing; Subsequent thawing; Cooling
- A23B2/82—Thawing subsequent to freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
- A61M1/0277—Frames constraining or supporting bags, e.g. during freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B2600/00—Control issues
- F25B2600/07—Remote controls
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
- F25D2331/80—Type of cooled receptacles
- F25D2331/801—Bags
- F25D2331/8014—Bags for medical use
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/20—Carts specially adapted for transporting objects to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/30—Quick freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2500/00—Problems to be solved
- F25D2500/02—Geometry problems
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Combustion & Propulsion (AREA)
- Biomedical Technology (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Environmental Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Packages (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33462201P | 2001-11-01 | 2001-11-01 | |
| US60/334,622 | 2001-11-01 | ||
| PCT/US2002/035137 WO2003037083A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing and storing biopharmacuetical material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2466130A1 true CA2466130A1 (en) | 2003-05-08 |
Family
ID=23308033
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466130A Abandoned CA2466130A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing and storing biopharmaceutical material |
| CA002466122A Abandoned CA2466122A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing, storing and thawing biopharmaceutical material |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466122A Abandoned CA2466122A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing, storing and thawing biopharmaceutical material |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1441586B1 (enExample) |
| JP (2) | JP2005507692A (enExample) |
| CN (3) | CN1242670C (enExample) |
| AT (2) | ATE330466T1 (enExample) |
| CA (2) | CA2466130A1 (enExample) |
| DE (2) | DE60212680T2 (enExample) |
| DK (2) | DK1441585T3 (enExample) |
| ES (2) | ES2265057T3 (enExample) |
| WO (2) | WO2003037082A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2266857T3 (es) * | 2002-09-23 | 2007-03-01 | Integrated Biosystems Inc. | Sistemas y procedimientos para congelar, almacenar, transportar y descongelar material biofarmaceutico. |
| CN1726375A (zh) * | 2002-12-13 | 2006-01-25 | 综合生物系统公司 | 用于生物药物和生物制剂的小量冻融系统 |
| DE102004015090A1 (de) | 2004-03-25 | 2005-11-03 | Hüttinger Elektronik Gmbh + Co. Kg | Bogenentladungserkennungseinrichtung |
| JP4939405B2 (ja) | 2005-04-28 | 2012-05-23 | 株式会社大塚製薬工場 | 薬液容器収容体およびその製造方法 |
| WO2007023907A1 (ja) * | 2005-08-24 | 2007-03-01 | Transcu Ltd. | 冷凍型イオントフォレーシス用電極構造体 |
| WO2007065141A2 (en) * | 2005-12-02 | 2007-06-07 | Smithkline Beecham Corporation | Freezing and storage container for biopharmaceutical drug products |
| WO2007103917A2 (en) * | 2006-03-06 | 2007-09-13 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| SG175625A1 (en) * | 2006-10-27 | 2011-11-28 | Otsuka Pharma Co Ltd | Drug solution having reduced dissolved oxygen content, method of producing the same and drug solution containing unit having reduced dissolved oxygen content |
| EP2240012B1 (en) * | 2007-12-21 | 2015-10-07 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US8177123B2 (en) * | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US9301520B2 (en) | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| EP2389063B1 (de) | 2009-01-20 | 2012-10-24 | F. Hoffmann-La Roche AG | Kryobehälter |
| US20110017743A1 (en) * | 2009-07-22 | 2011-01-27 | Honeywell International Inc. | Sealable container linings and sealable containers |
| US8371132B2 (en) * | 2009-11-23 | 2013-02-12 | Sartorius Stedim North America Inc. | Systems and methods for use in freezing, thawing, and storing biopharmaceutical materials |
| IT1397926B1 (it) * | 2010-02-12 | 2013-02-04 | Angelantoni Ind Spa | Congelatore rapido per sacche con rilevazione della temperatura delle sacche. |
| PT105405B (pt) * | 2010-11-26 | 2014-08-21 | Univ Lisboa | Processo e aparelho de congelação em pratos para obtenção de matrizes de gelo com distribuição de solutos uniforme |
| EP2691719A4 (en) * | 2011-03-28 | 2015-05-27 | Praxair Technology Inc | MASS INFRINGEMENT OF BIOPHARMAZEUTIKA |
| CN102322725B (zh) * | 2011-09-13 | 2013-06-12 | 东莞市品翔饮水设备有限公司 | 制冰、制冷、制热直饮机 |
| DE102012007904B4 (de) * | 2012-04-23 | 2015-08-27 | Fresenius Medical Care Deutschland Gmbh | Beutel mit verbundenem biegesteifen Kunststoffteil |
| US9357766B2 (en) * | 2012-07-10 | 2016-06-07 | Lifeline Scientific, Inc. | Organ transport apparatus with a document compartment and a tamper evident seal |
| US9441893B2 (en) * | 2012-07-25 | 2016-09-13 | Grifols, S.A. | Thawing vessel for biological products |
| KR102074024B1 (ko) | 2012-10-31 | 2020-02-05 | 플루리스템 리미티드 | 생물학적 물질을 해동하기 위한 방법 및 장치 |
| FR3003644B1 (fr) | 2013-03-22 | 2015-03-20 | Sartorius Stedim North America Inc | Controle de l'etat de congelation d'un fluide biopharmaceutique se trouvant dans un conteneur. |
| FR3003550B1 (fr) | 2013-03-22 | 2016-05-06 | Sartorius Stedim North America Inc | Installation et procede pour la preparation d'un conteneur charge avec un fluide biopharmaceutique. |
| CN103392691B (zh) * | 2013-08-14 | 2015-09-23 | 北京瑞健高科生物科技有限公司 | 一种生物组织处理、灭菌及保存的容器和方法 |
| PT107427B (pt) * | 2014-01-28 | 2021-01-04 | Inst Superior Tecnico | Sistema e método de preservação, armazenamento e transporte de materiais biológicos. |
| CA3187726A1 (en) | 2014-08-08 | 2016-02-11 | Fremon Scientific, Inc. | Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance |
| EP3199023B1 (en) | 2016-01-27 | 2021-01-20 | Sartorius Stedim North America Inc. | Method and system for freezing biopharmaceutical fluid |
| JP6696870B2 (ja) * | 2016-09-23 | 2020-05-20 | 大陽日酸株式会社 | 液体用バッグの急速凍結方法および急速凍結装置 |
| US11304874B2 (en) * | 2016-11-04 | 2022-04-19 | Sartorius Stedim North America, Inc. | Protecting body for a flexible pouch, system for containing a biopharmaceutical fluid and methods for using such a system |
| JP6872369B2 (ja) * | 2017-01-11 | 2021-05-19 | 藤森工業株式会社 | 注出口付き包装袋 |
| CN108353890B (zh) * | 2018-02-13 | 2021-01-26 | 京东方科技集团股份有限公司 | 一种生物片材固定装置 |
| CN108357763B (zh) | 2018-02-13 | 2019-07-16 | 京东方科技集团股份有限公司 | 一种生物片材存储装置 |
| CN112165859B (zh) * | 2018-03-29 | 2023-03-21 | W.L.戈尔及同仁股份有限公司 | 用于冷冻、储存、输送和解冻生物产品储存袋的承载件 |
| EP3773412A4 (en) * | 2018-04-11 | 2022-02-16 | BioLife Solutions, Inc. | SYSTEM AND METHODS FOR PROTECTING CRYOPRESERVATION POUCHES |
| WO2019217488A1 (en) | 2018-05-07 | 2019-11-14 | Fremon Scientific, Inc. | Thawing biological substances |
| NL2023121B1 (en) * | 2019-05-13 | 2020-12-01 | Nutritious Juices & Soups B V | Food product dispensing system |
| CN111503978A (zh) * | 2020-04-27 | 2020-08-07 | 上海东富龙科技股份有限公司 | 一种用于生物制药材料冷冻、解冻工艺的装置 |
| CN111503997B (zh) * | 2020-04-27 | 2022-02-08 | 上海东富龙科技股份有限公司 | 一种用于生物制药材料冷冻、解冻或混合工艺处理的冻融系统 |
| CN111503959A (zh) * | 2020-04-27 | 2020-08-07 | 上海东富龙科技股份有限公司 | 一种用于生物制药材料冷冻、解冻工艺处理的冻融机 |
| US11571359B2 (en) * | 2020-07-30 | 2023-02-07 | Sartorius Stedim North America | Storage/containment unit for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body |
| US11590056B2 (en) | 2020-07-30 | 2023-02-28 | Sartorius Stedim North America | Freeze/thaw containment system for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body |
| US11590055B2 (en) | 2020-07-30 | 2023-02-28 | Sartorius Stedim North America | Storage/containment unit for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body |
| EP3960640A1 (en) | 2020-08-28 | 2022-03-02 | Sartorius Stedim Biotech GmbH | Safety device for a single-use mixing or storage system |
| US12239127B2 (en) | 2021-07-28 | 2025-03-04 | Sartorius Stedim North America Inc. | Thermal capacitors, systems, and methods for rapid freezing or heating of biological materials |
| JP7649231B2 (ja) * | 2021-11-10 | 2025-03-19 | 大陽日酸株式会社 | 予備凍結用ラック及び予備凍結方法 |
| CN114471754A (zh) * | 2021-12-27 | 2022-05-13 | 利穗科技(苏州)有限公司 | 一种用于生物材料水溶液的容器 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557870A1 (de) * | 1975-12-22 | 1977-06-23 | Linde Ag | Verfahren und vorrichtung zum tiefgefrieren von biologischen substanzen |
| DE3238535A1 (de) * | 1982-10-18 | 1984-04-19 | Planer Products Ltd., Sunbury-on-Thames, Middlesex | Verfahren und apparat zum gesteuerten kuehlen eines produktes |
| GB2196830B (en) * | 1986-11-06 | 1990-08-29 | Gkn Vending Services Ltd | Storing pre-cooked food for vending |
| CN2084914U (zh) * | 1990-10-30 | 1991-09-18 | 中国医科大学附属第三医院 | 多功能变温贮血器 |
| US5891617A (en) * | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
| JP3037595B2 (ja) * | 1995-10-13 | 2000-04-24 | 岐阜プラスチック工業株式会社 | 運搬容器 |
| NL1004619C2 (nl) * | 1996-11-26 | 1998-05-27 | Instituut Voor Dierhouderij En | Inrichting en werkwijze voor het invriezen van levende cellen, in het bijzonder sperma. |
-
2002
- 2002-11-01 DE DE60212680T patent/DE60212680T2/de not_active Expired - Lifetime
- 2002-11-01 EP EP02778703A patent/EP1441586B1/en not_active Expired - Lifetime
- 2002-11-01 DK DK02778702T patent/DK1441585T3/da active
- 2002-11-01 AT AT02778703T patent/ATE330466T1/de not_active IP Right Cessation
- 2002-11-01 CN CNB028218582A patent/CN1242670C/zh not_active Expired - Fee Related
- 2002-11-01 DK DK02778703T patent/DK1441586T3/da active
- 2002-11-01 CN CNB2005100978176A patent/CN1315374C/zh not_active Expired - Fee Related
- 2002-11-01 WO PCT/US2002/035135 patent/WO2003037082A1/en not_active Ceased
- 2002-11-01 AT AT02778702T patent/ATE326841T1/de not_active IP Right Cessation
- 2002-11-01 JP JP2003539440A patent/JP2005507692A/ja active Pending
- 2002-11-01 CA CA002466130A patent/CA2466130A1/en not_active Abandoned
- 2002-11-01 WO PCT/US2002/035137 patent/WO2003037083A1/en not_active Ceased
- 2002-11-01 CN CNB028218566A patent/CN1229018C/zh not_active Expired - Lifetime
- 2002-11-01 ES ES02778702T patent/ES2265057T3/es not_active Expired - Lifetime
- 2002-11-01 CA CA002466122A patent/CA2466122A1/en not_active Abandoned
- 2002-11-01 DE DE60211731T patent/DE60211731T2/de not_active Expired - Lifetime
- 2002-11-01 EP EP02778702A patent/EP1441585B1/en not_active Expired - Lifetime
- 2002-11-01 JP JP2003539439A patent/JP2005523843A/ja active Pending
- 2002-11-01 ES ES02778703T patent/ES2266588T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003037082A9 (en) | 2004-01-15 |
| WO2003037082A1 (en) | 2003-05-08 |
| CN1229018C (zh) | 2005-11-30 |
| ATE326841T1 (de) | 2006-06-15 |
| DE60211731T2 (de) | 2007-05-16 |
| ES2266588T3 (es) | 2007-03-01 |
| CN1242670C (zh) | 2006-02-22 |
| DE60212680T2 (de) | 2007-06-28 |
| JP2005523843A (ja) | 2005-08-11 |
| EP1441585A1 (en) | 2004-08-04 |
| WO2003037083A1 (en) | 2003-05-08 |
| DE60212680D1 (de) | 2006-08-03 |
| CN1315374C (zh) | 2007-05-16 |
| CN1582112A (zh) | 2005-02-16 |
| HK1087889A1 (en) | 2006-10-27 |
| HK1074748A1 (en) | 2005-11-25 |
| ES2265057T3 (es) | 2007-02-01 |
| CN1582111A (zh) | 2005-02-16 |
| ATE330466T1 (de) | 2006-07-15 |
| DK1441586T3 (da) | 2006-10-23 |
| EP1441586B1 (en) | 2006-06-21 |
| WO2003037083A9 (en) | 2004-01-15 |
| DK1441585T3 (da) | 2006-10-02 |
| DE60211731D1 (de) | 2006-06-29 |
| CA2466122A1 (en) | 2003-05-08 |
| CN1732776A (zh) | 2006-02-15 |
| EP1441585B1 (en) | 2006-05-24 |
| HK1074749A1 (en) | 2005-11-25 |
| EP1441586A1 (en) | 2004-08-04 |
| JP2005507692A (ja) | 2005-03-24 |
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