CA2458808A1 - Aminopyrrole compounds as antiinflammatory agents - Google Patents

Aminopyrrole compounds as antiinflammatory agents Download PDF

Info

Publication number
CA2458808A1
CA2458808A1 CA002458808A CA2458808A CA2458808A1 CA 2458808 A1 CA2458808 A1 CA 2458808A1 CA 002458808 A CA002458808 A CA 002458808A CA 2458808 A CA2458808 A CA 2458808A CA 2458808 A1 CA2458808 A1 CA 2458808A1
Authority
CA
Canada
Prior art keywords
compound
disease
formula
phenyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002458808A
Other languages
English (en)
French (fr)
Inventor
David Michael Goldstein
David Mark Rotstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2458808A1 publication Critical patent/CA2458808A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002458808A 2001-08-30 2002-08-26 Aminopyrrole compounds as antiinflammatory agents Abandoned CA2458808A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31616901P 2001-08-30 2001-08-30
US60/316,169 2001-08-30
PCT/EP2002/009505 WO2003020715A1 (en) 2001-08-30 2002-08-26 Aminopyrrole compounds as antiinflammatory agents

Publications (1)

Publication Number Publication Date
CA2458808A1 true CA2458808A1 (en) 2003-03-13

Family

ID=23227809

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002458808A Abandoned CA2458808A1 (en) 2001-08-30 2002-08-26 Aminopyrrole compounds as antiinflammatory agents

Country Status (16)

Country Link
US (1) US6696471B2 (enExample)
EP (1) EP1423378B1 (enExample)
JP (1) JP2005506324A (enExample)
KR (1) KR20040029075A (enExample)
CN (1) CN1281603C (enExample)
AR (1) AR037140A1 (enExample)
AT (1) ATE309239T1 (enExample)
AU (1) AU2002331179B2 (enExample)
BR (1) BR0212077A (enExample)
CA (1) CA2458808A1 (enExample)
DE (1) DE60207273T2 (enExample)
ES (1) ES2252509T3 (enExample)
MX (1) MXPA04001810A (enExample)
PL (1) PL373115A1 (enExample)
RU (1) RU2315045C2 (enExample)
WO (1) WO2003020715A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20080113016A1 (en) * 2004-07-26 2008-05-15 Gary Steven Firestein Method for Prevention or Treatment of Inflammatory Disease
CA2681420A1 (en) * 2007-03-20 2008-09-25 Cadila Pharmaceuticals Limited P38 inhibitors
DK3368052T3 (da) 2015-10-27 2022-03-14 Childrens Hospital Med Ct Anvendelse af mapk-hæmmere for at nedbringe tabet af hæmatopoietiske stamceller under ex vivo-dyrkning og -genmanipulation
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
ES2927715T3 (es) 2017-10-05 2022-11-10 Fulcrum Therapeutics Inc Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
AU3044197A (en) 1996-07-11 1998-02-09 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
WO1998007425A1 (en) * 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
PL344004A1 (en) 1998-05-05 2001-09-10 Hoffmann La Roche Pyrazole derivatives as p-38 map kinase inhibitors
WO1999058523A1 (en) * 1998-05-14 1999-11-18 G.D. Searle & Co. 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS

Also Published As

Publication number Publication date
ES2252509T3 (es) 2006-05-16
DE60207273T2 (de) 2006-07-20
DE60207273D1 (de) 2005-12-15
PL373115A1 (en) 2005-08-08
EP1423378A1 (en) 2004-06-02
EP1423378B1 (en) 2005-11-09
AR037140A1 (es) 2004-10-27
CN1547578A (zh) 2004-11-17
RU2315045C2 (ru) 2008-01-20
US6696471B2 (en) 2004-02-24
AU2002331179B2 (en) 2008-04-17
ATE309239T1 (de) 2005-11-15
US20030130319A1 (en) 2003-07-10
RU2004109817A (ru) 2005-10-20
CN1281603C (zh) 2006-10-25
MXPA04001810A (es) 2004-07-08
WO2003020715A1 (en) 2003-03-13
JP2005506324A (ja) 2005-03-03
KR20040029075A (ko) 2004-04-03
BR0212077A (pt) 2004-09-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued