CA2448382C - Use of hepcidin as a regulator of iron homeostasis - Google Patents
Use of hepcidin as a regulator of iron homeostasis Download PDFInfo
- Publication number
- CA2448382C CA2448382C CA2448382A CA2448382A CA2448382C CA 2448382 C CA2448382 C CA 2448382C CA 2448382 A CA2448382 A CA 2448382A CA 2448382 A CA2448382 A CA 2448382A CA 2448382 C CA2448382 C CA 2448382C
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- Prior art keywords
- hepcidin
- iron
- mice
- usf2
- medicament
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Landscapes
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| EP01401537.4 | 2001-06-14 | ||
| EP01401537A EP1262187A1 (en) | 2001-05-25 | 2001-06-14 | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| EP02290795.0 | 2002-03-29 | ||
| EP02290795 | 2002-03-29 | ||
| PCT/EP2002/006924 WO2002098444A2 (en) | 2001-05-25 | 2002-05-24 | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
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| CA2448382A1 CA2448382A1 (en) | 2002-12-12 |
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| TR (1) | TR201806761T4 (enExample) |
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| CA2448382C (en) * | 2001-05-25 | 2013-02-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin as a regulator of iron homeostasis |
| EP1578254B1 (en) | 2002-11-19 | 2013-03-06 | DRG International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor |
| US8017737B2 (en) | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| US7411048B2 (en) | 2002-11-19 | 2008-08-12 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids |
| DE10349124A1 (de) | 2003-10-22 | 2005-05-19 | Roche Diagnostics Gmbh | Differenzialdiagnostik mit Hepcidin |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| KR100679100B1 (ko) * | 2004-10-29 | 2007-02-06 | 엘지.필립스 엘시디 주식회사 | 수평 전계 인가형 액정 표시 패널 및 그 제조방법 |
| US7968091B2 (en) | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| EP2371957A1 (en) * | 2006-04-12 | 2011-10-05 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to hepcidin |
| AU2007275638B2 (en) * | 2006-07-21 | 2014-01-16 | Amgen Inc. | Method of detecting and/ or measuring hepcidin in a sample |
| CA2663581C (en) | 2006-09-21 | 2016-03-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the hamp gene |
| JPWO2008047485A1 (ja) * | 2006-10-17 | 2010-02-18 | 直久 友杉 | 活性型ヘプシジンを指標とした、鉄代謝異常の診断方法 |
| PE20090722A1 (es) * | 2007-02-02 | 2009-07-13 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| US8895002B2 (en) | 2007-04-09 | 2014-11-25 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| JPWO2008146903A1 (ja) * | 2007-05-31 | 2010-08-19 | 直久 友杉 | 活性型ヘプシジンを指標とした、急性虚血性疾患の診断方法 |
| ATE553778T1 (de) | 2007-10-02 | 2012-05-15 | Inst Nat Sante Rech Med | Für humanes hepcidin spezifische antikörper |
| EP2201382A4 (en) | 2007-10-26 | 2011-01-26 | Univ Utah Res Found | IDENTIFICATION OF THE HEPCIDIN BINDING PLACE OF FERROPORTIN |
| AR069062A1 (es) * | 2007-11-02 | 2009-12-23 | Lilly Co Eli | Anticuerpo anti-hepcidina |
| EP2816059A1 (en) | 2008-05-01 | 2014-12-24 | Amgen, Inc | Anti-hepcidin antibodies and methods of use |
| ES2432018T3 (es) * | 2008-08-06 | 2013-11-29 | Eli Lilly And Company | Anticuerpos selectivos anti-hepcidina-25 y usos de los mismos |
| US20100068737A1 (en) * | 2008-09-16 | 2010-03-18 | University Of Tennessee Research Foundation | Enzyme-linked Immunosorbent Assay (ELISA) for Canine Hepcidin |
| EP2349332B1 (en) * | 2008-11-13 | 2019-10-23 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation bmp-6 |
| US8999935B2 (en) * | 2009-02-11 | 2015-04-07 | New York University | Treatment of osteoporosis in peri- and post-menopausal women with hepcidin |
| DE102009034150A1 (de) | 2009-07-20 | 2011-01-27 | Fresenius Medical Care Deutschland Gmbh | Adsorbens zur Adsorption von Hepcidin |
| AR077892A1 (es) | 2009-08-20 | 2011-09-28 | Vifor Int Ag | Quinolinas antagonistas de la hepcidina |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| TW201113274A (en) | 2009-09-07 | 2011-04-16 | Vifor Int Ag | Novel ethanediamine hepcidine antagonists |
| AR078278A1 (es) | 2009-09-09 | 2011-10-26 | Vifor Int Ag | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| US9228188B2 (en) | 2011-06-21 | 2016-01-05 | Alnylam Pharmaceuticals, Inc. | Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression |
| WO2013002354A1 (ja) * | 2011-06-29 | 2013-01-03 | 株式会社ダナフォーム | 生体試料の前処理方法、ｒｎａの検出方法及び前処理キット |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| DK2968503T3 (en) | 2013-03-15 | 2018-12-03 | Intrinsic Lifesciences Llc | ANTI-HEPCIDIN ANTIBODIES AND APPLICATIONS THEREOF |
| US20160051556A1 (en) | 2013-03-21 | 2016-02-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and Pharmaceutical Composition for use in the Treatment of Chronic Liver Diseases Associated with a Low Hepcidin Expression |
| EP3197915A4 (en) | 2014-09-22 | 2018-12-19 | Intrinsic Lifesciences LLC | Humanized anti-hepcidin antibodies and uses thereof |
| EP3203991A4 (en) * | 2014-10-10 | 2018-06-20 | The Board of Regents of The University of Texas System | Hif-2 inhibitors for treating iron overload disorders |
| KR20180109917A (ko) * | 2016-01-08 | 2018-10-08 | 라 졸라 파마슈티칼 컴파니 | 헵시딘의 투여 방법 |
| WO2018165186A1 (en) * | 2017-03-07 | 2018-09-13 | Intrinsic Lifesciences Llc | Assessment of chronic iron deficiency |
| WO2019165252A1 (en) * | 2018-02-23 | 2019-08-29 | La Jolla Pharmaceutical Company | Compositions comprising hepcidin and methods of use thereof |
| US12011489B2 (en) | 2022-03-30 | 2024-06-18 | Christopher Key | Compositions and methods for treating inflammatory disease |
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| FR2766207B1 (fr) * | 1997-07-11 | 2000-12-08 | Rhone Poulenc Agrochimie | Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies |
| FR2770853B1 (fr) * | 1997-11-07 | 1999-12-31 | Rhone Poulenc Agrochimie | Gene codant pour la thanatine, vecteur le contenant et plantes transformees obtenues resistantes aux maladies |
| US7109292B2 (en) * | 1999-03-08 | 2006-09-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2000056879A1 (en) * | 1999-03-22 | 2000-09-28 | Universität Zürich | TRANSFORMING GROWTH FACTOR (TFG) β SUPERFAMILY ANTAGONISTS |
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