CN101884780B - Hepcidin作为铁稳态调节剂的用途 - Google Patents
Hepcidin作为铁稳态调节剂的用途 Download PDFInfo
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- CN101884780B CN101884780B CN201010232752.2A CN201010232752A CN101884780B CN 101884780 B CN101884780 B CN 101884780B CN 201010232752 A CN201010232752 A CN 201010232752A CN 101884780 B CN101884780 B CN 101884780B
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Landscapes
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01401377 | 2001-05-25 | ||
| EP01401377.5 | 2001-05-25 | ||
| EP01401537.4 | 2001-06-14 | ||
| EP01401537A EP1262187A1 (en) | 2001-05-25 | 2001-06-14 | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| EP02290795 | 2002-03-29 | ||
| EP02290795.0 | 2002-03-29 | ||
| CN028148150A CN1612746B (zh) | 2001-05-25 | 2002-05-24 | Hepcidin作为制备铁稳态调节剂的用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN028148150A Division CN1612746B (zh) | 2001-05-25 | 2002-05-24 | Hepcidin作为制备铁稳态调节剂的用途 |
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| CN101884780A CN101884780A (zh) | 2010-11-17 |
| CN101884780B true CN101884780B (zh) | 2018-09-21 |
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| CN201010232752.2A Expired - Fee Related CN101884780B (zh) | 2001-05-25 | 2002-05-24 | Hepcidin作为铁稳态调节剂的用途 |
| CN028148150A Expired - Fee Related CN1612746B (zh) | 2001-05-25 | 2002-05-24 | Hepcidin作为制备铁稳态调节剂的用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN028148150A Expired - Fee Related CN1612746B (zh) | 2001-05-25 | 2002-05-24 | Hepcidin作为制备铁稳态调节剂的用途 |
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| EP (2) | EP2186524B1 (enExample) |
| JP (4) | JP4944360B2 (enExample) |
| CN (2) | CN101884780B (enExample) |
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| ES (2) | ES2326469T5 (enExample) |
| TR (1) | TR201806761T4 (enExample) |
| WO (1) | WO2002098444A2 (enExample) |
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| EP2186524B1 (en) | 2001-05-25 | 2018-02-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| US7411048B2 (en) | 2002-11-19 | 2008-08-12 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids |
| RU2359268C2 (ru) | 2002-11-19 | 2009-06-20 | ДиАрДжи ИНТЕРНЭШНЛ, ИНК. | Способ диагностики заболеваний путем скрининга тканей, крови или жидкостей организма животных или человека на предмет обнаружения нефизиологических уровней гепсидина и его терапевтическое применение |
| US8017737B2 (en) | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| DE10349124A1 (de) | 2003-10-22 | 2005-05-19 | Roche Diagnostics Gmbh | Differenzialdiagnostik mit Hepcidin |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| KR100679100B1 (ko) * | 2004-10-29 | 2007-02-06 | 엘지.필립스 엘시디 주식회사 | 수평 전계 인가형 액정 표시 패널 및 그 제조방법 |
| CA2597925A1 (en) | 2005-02-16 | 2006-08-24 | The General Hospital Corporation | Use of a human hemojuvelin product to regulate hepcidin-mediated iron metabolism |
| EP2016177A2 (en) * | 2006-04-12 | 2009-01-21 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to hepcidin |
| JP5410971B2 (ja) * | 2006-07-21 | 2014-02-05 | アムジエン・インコーポレーテツド | サンプル中のヘプシジンを検出および／または測定する方法 |
| CA2663581C (en) | 2006-09-21 | 2016-03-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the hamp gene |
| JPWO2008047485A1 (ja) * | 2006-10-17 | 2010-02-18 | 直久 友杉 | 活性型ヘプシジンを指標とした、鉄代謝異常の診断方法 |
| PE20090722A1 (es) * | 2007-02-02 | 2009-07-13 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| WO2008124768A1 (en) | 2007-04-09 | 2008-10-16 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| WO2008146903A1 (ja) * | 2007-05-31 | 2008-12-04 | Naohisa Tomosugi | 活性型ヘプシジンを指標とした、急性虚血性疾患の診断方法 |
| JP2010539969A (ja) | 2007-10-02 | 2010-12-24 | アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | ヒトヘプシジンに対して特異性を有する抗原結合タンパク質 |
| US8530619B2 (en) | 2007-10-26 | 2013-09-10 | University Of Utah Research Foundation | Identification of the hepcidin binding site on ferroportin |
| PE20091261A1 (es) | 2007-11-02 | 2009-08-17 | Lilly Co Eli | Anticuerpos anti-hepcidina |
| US9315577B2 (en) | 2008-05-01 | 2016-04-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| CA2733497C (en) * | 2008-08-06 | 2015-06-02 | Eli Lilly And Company | Anti-hepcidin-25 selective antibodies and uses thereof |
| US20100068737A1 (en) * | 2008-09-16 | 2010-03-18 | University Of Tennessee Research Foundation | Enzyme-linked Immunosorbent Assay (ELISA) for Canine Hepcidin |
| CN102215869B (zh) * | 2008-11-13 | 2015-05-13 | 通用医疗公司 | 用于通过调整bmp-6来调节铁稳态的方法和组合物 |
| US8999935B2 (en) * | 2009-02-11 | 2015-04-07 | New York University | Treatment of osteoporosis in peri- and post-menopausal women with hepcidin |
| DE102009034150A1 (de) | 2009-07-20 | 2011-01-27 | Fresenius Medical Care Deutschland Gmbh | Adsorbens zur Adsorption von Hepcidin |
| CN102574805A (zh) | 2009-08-20 | 2012-07-11 | 维福（国际）股份公司 | 新型喹啉铁调素拮抗剂 |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| TW201113274A (en) | 2009-09-07 | 2011-04-16 | Vifor Int Ag | Novel ethanediamine hepcidine antagonists |
| WO2011029832A1 (de) | 2009-09-09 | 2011-03-17 | Vifor (International) Ag | Neue thiazol- und oxazol-hepcidin-antagonisten |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| US9228188B2 (en) | 2011-06-21 | 2016-01-05 | Alnylam Pharmaceuticals, Inc. | Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression |
| CN103097531B (zh) * | 2011-06-29 | 2016-11-23 | 达纳福股份有限公司 | 生物样本的预处理方法、rna的检测方法及预处理试剂盒 |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| KR102218494B1 (ko) | 2013-03-15 | 2021-02-19 | 인트린식 라이프사이언시스, 엘엘씨 | 항-헵시딘 항체 및 그의 용도 |
| WO2014147246A1 (en) | 2013-03-21 | 2014-09-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression |
| US10323088B2 (en) | 2014-09-22 | 2019-06-18 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| WO2016057242A1 (en) * | 2014-10-10 | 2016-04-14 | The Board Of Regents Of The University Of Texas System | HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS |
| JP2019505517A (ja) * | 2016-01-08 | 2019-02-28 | ラ ホヤ ファーマシューティカル カンパニーＬａ Ｊｏｌｌａ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｍｐａｎｙ | ヘプシジンを投与する方法 |
| WO2018165186A1 (en) * | 2017-03-07 | 2018-09-13 | Intrinsic Lifesciences Llc | Assessment of chronic iron deficiency |
| WO2019165252A1 (en) * | 2018-02-23 | 2019-08-29 | La Jolla Pharmaceutical Company | Compositions comprising hepcidin and methods of use thereof |
| US12011489B2 (en) | 2022-03-30 | 2024-06-18 | Christopher Key | Compositions and methods for treating inflammatory disease |
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| FR2766207B1 (fr) * | 1997-07-11 | 2000-12-08 | Rhone Poulenc Agrochimie | Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies |
| FR2770853B1 (fr) * | 1997-11-07 | 1999-12-31 | Rhone Poulenc Agrochimie | Gene codant pour la thanatine, vecteur le contenant et plantes transformees obtenues resistantes aux maladies |
| US7109292B2 (en) * | 1999-03-08 | 2006-09-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU3269399A (en) * | 1999-03-22 | 2000-10-09 | Universitat Zurich | Transforming growth factor (tfg) beta superfamily antagonists |
| EP2186524B1 (en) * | 2001-05-25 | 2018-02-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| US8017737B2 (en) * | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| US7411048B2 (en) * | 2002-11-19 | 2008-08-12 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids |
| RU2359268C2 (ru) † | 2002-11-19 | 2009-06-20 | ДиАрДжи ИНТЕРНЭШНЛ, ИНК. | Способ диагностики заболеваний путем скрининга тканей, крови или жидкостей организма животных или человека на предмет обнаружения нефизиологических уровней гепсидина и его терапевтическое применение |
| CA2597925A1 (en) * | 2005-02-16 | 2006-08-24 | The General Hospital Corporation | Use of a human hemojuvelin product to regulate hepcidin-mediated iron metabolism |
| CN101522022B (zh) * | 2006-09-16 | 2013-05-08 | 大豆实验室公司 | 利用大豆肽降低总胆固醇水平和ldl胆固醇水平的产品和方法 |
| PE20090722A1 (es) † | 2007-02-02 | 2009-07-13 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| JP2010539969A (ja) * | 2007-10-02 | 2010-12-24 | アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | ヒトヘプシジンに対して特異性を有する抗原結合タンパク質 |
| WO2009097461A1 (en) | 2008-01-29 | 2009-08-06 | Neoguide Systems Inc. | Apparatus and methods for automatically controlling an endoscope |
| CN102245626A (zh) † | 2008-12-05 | 2011-11-16 | 加利福尼亚大学董事会 | 微型铁调素肽及其使用方法 |
| CA2855122A1 (en) | 2011-12-09 | 2013-06-13 | The Regents Of The University Of California | Modified mini-hepcidin peptides and methods of using thereof |
| CA2948283A1 (en) | 2014-04-07 | 2015-10-15 | Merganser Biotech, Inc. | Hepcidin mimetic peptides and uses thereof |
| US20170313754A1 (en) | 2014-06-27 | 2017-11-02 | Protagonist Therapeutics, Inc. | Hepcidin and mini-hepcidin analogues and uses thereof |
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