CA2441599A1 - Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain - Google Patents
Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain Download PDFInfo
- Publication number
- CA2441599A1 CA2441599A1 CA002441599A CA2441599A CA2441599A1 CA 2441599 A1 CA2441599 A1 CA 2441599A1 CA 002441599 A CA002441599 A CA 002441599A CA 2441599 A CA2441599 A CA 2441599A CA 2441599 A1 CA2441599 A1 CA 2441599A1
- Authority
- CA
- Canada
- Prior art keywords
- c4alkyl
- phenyl
- compound
- substituted
- c6alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 208000002193 Pain Diseases 0.000 title claims abstract description 11
- 239000000085 vanilloid receptor antagonist Substances 0.000 title description 4
- 150000003222 pyridines Chemical class 0.000 title description 3
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- 239000003814 drug Substances 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 5
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 36
- 150000003839 salts Chemical group 0.000 claims description 34
- 239000002253 acid Substances 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 28
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical group 0.000 claims description 18
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
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- YYASVUNKUYCHIU-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-(dimethylamino)-4,4-dimethylpent-1-en-3-one Chemical compound CN(C)C=C(C(=O)C(C)(C)C)C1=CC=C(Cl)C=C1 YYASVUNKUYCHIU-UHFFFAOYSA-N 0.000 claims description 6
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- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107505A GB0107505D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0107505.0 | 2001-03-26 | ||
| US33828101P | 2001-12-06 | 2001-12-06 | |
| US60/338,281 | 2001-12-06 | ||
| PCT/EP2002/003332 WO2002076946A2 (en) | 2001-03-26 | 2002-03-25 | Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2441599A1 true CA2441599A1 (en) | 2002-10-03 |
Family
ID=26245894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002441599A Abandoned CA2441599A1 (en) | 2001-03-26 | 2002-03-25 | Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7915264B2 (enExample) |
| EP (1) | EP1377576A2 (enExample) |
| JP (1) | JP4205430B2 (enExample) |
| KR (1) | KR20030083755A (enExample) |
| CN (1) | CN1500089A (enExample) |
| BR (1) | BR0208338A (enExample) |
| CA (1) | CA2441599A1 (enExample) |
| CZ (1) | CZ20032561A3 (enExample) |
| HU (1) | HUP0303623A2 (enExample) |
| IL (1) | IL157815A0 (enExample) |
| MX (1) | MXPA03008754A (enExample) |
| NO (1) | NO326546B1 (enExample) |
| PE (1) | PE20021161A1 (enExample) |
| PL (1) | PL363907A1 (enExample) |
| RU (1) | RU2003130221A (enExample) |
| SK (1) | SK11952003A3 (enExample) |
| WO (1) | WO2002076946A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ523882A (en) | 2000-08-21 | 2004-11-26 | Pacific Corp | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| EP1311478B1 (en) | 2000-08-21 | 2006-06-07 | Pacific Corporation | Novel (thio)urea compounds and the pharmaceutical compositions containing the same |
| RS63204A (sr) | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina |
| AU2003212882A1 (en) | 2002-02-01 | 2003-09-02 | Euro-Celtique S.A. | 2 - piperazine - pyridines useful for treating pain |
| US6864261B2 (en) | 2002-05-02 | 2005-03-08 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| GB0229808D0 (en) | 2002-12-20 | 2003-01-29 | Glaxo Group Ltd | Novel compositions |
| US7531558B2 (en) | 2003-02-14 | 2009-05-12 | Glaxo Group Limited | Carboxamide derivatives |
| ATE556067T1 (de) | 2003-05-20 | 2012-05-15 | Ajinomoto Kk | Modulatoren des vanilloid rezeptors |
| GB0319150D0 (en) | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| EP1687306A1 (en) | 2003-11-14 | 2006-08-09 | MERCK SHARP & DOHME LTD. | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| WO2006019965A2 (en) * | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| JP2008508190A (ja) | 2004-07-19 | 2008-03-21 | ノボ ノルディスク アクティーゼルスカブ | 肥満または肥満に関連する疾患および障害の治療におけるカプサイシン受容体の活性の阻害 |
| DE102004039373A1 (de) * | 2004-08-12 | 2006-02-23 | Grünenthal GmbH | Para-Alkyl-substituierte N-(4-Hydroxy-3-methoxy-benzyl)-zimtsäureamide und deren Verwendung zur Herstellung von Arzneimitteln |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| WO2006098554A1 (en) * | 2005-03-16 | 2006-09-21 | Amorepacific Corporation | Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same |
| GB0506147D0 (en) * | 2005-03-24 | 2005-05-04 | Merck Sharp & Dohme | Therapeutic agents |
| GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| AU2006244027A1 (en) * | 2005-05-11 | 2006-11-16 | Merck Sharp & Dohme Limited | 2,3-substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilloid-1 receptor (VR1) |
| WO2007045462A2 (de) * | 2005-10-19 | 2007-04-26 | Grünenthal GmbH | Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| KR100761222B1 (ko) * | 2006-03-08 | 2007-10-04 | 성균관대학교산학협력단 | 약물의존중독을 예방 및 치료하기 위한 바닐로이드 수용체길항제 |
| GB0614471D0 (en) | 2006-07-20 | 2006-08-30 | Syngenta Ltd | Herbicidal Compounds |
| EA200900330A1 (ru) | 2006-08-23 | 2009-08-28 | Ньюроджен Корпорейшн | Аналоги 2-феноксипиримидинона |
| EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
| CL2008001112A1 (es) * | 2007-04-20 | 2008-12-19 | Novartis Ag | Usos de compuestos derivados de pirido[2,3-d]pirimidin-4-ona para tratar comezon o un trastorno relacionado con comezon; combinacion de los compuestos con otro farmaco; y uso de la combinacion para tratar la comezon o un trastorno relacionado con comezon. |
| ES2648225T3 (es) * | 2007-07-18 | 2017-12-29 | Novartis Ag | Combinaciones sinérgicas de antagonistas de VR-1 e inhibidores de COX-2 |
| GEP20125574B (en) * | 2008-01-11 | 2012-07-10 | Glenmark Pharmaceuticals Sa | Fused pyrimidine derivatives as trpv3 modulators |
| WO2009121036A2 (en) * | 2008-03-27 | 2009-10-01 | Neurogen Corporation | Substituted aryl pyrimidinone derivatives |
| CN101983197B (zh) | 2008-04-18 | 2015-04-22 | 大熊制药株式会社 | 新型苯并噁嗪苯并咪唑衍生物、含有该衍生物的药物组合物及其用途 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| WO2013164790A1 (en) | 2012-05-03 | 2013-11-07 | Novartis Ag | L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
| CN107108429B (zh) | 2015-12-23 | 2022-08-19 | 联邦科学与工业研究组织 | 化合物 |
| CN108863949B (zh) * | 2018-07-09 | 2021-01-15 | 湖南博隽生物医药有限公司 | 一种用于治疗慢性炎性痛的辣椒素受体拮抗剂及合成方法 |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
| CN114605408B (zh) * | 2022-03-30 | 2023-06-16 | 沈阳药科大学 | 5-羟基-1,3-二取代苯基吡啶并[2,3-d]嘧啶类化合物及其制法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2749344A (en) * | 1953-01-02 | 1956-06-05 | Burroughs Wellcome Co | Pyrimidine compounds |
| US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
| IL112235A (en) | 1994-01-03 | 2000-06-29 | Acea Pharm Inc | 1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them |
| FR2750862B1 (fr) | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques |
-
2002
- 2002-03-25 CZ CZ20032561A patent/CZ20032561A3/cs unknown
- 2002-03-25 CN CNA028073495A patent/CN1500089A/zh active Pending
- 2002-03-25 EP EP02730062A patent/EP1377576A2/en not_active Withdrawn
- 2002-03-25 RU RU2003130221/04A patent/RU2003130221A/ru not_active Application Discontinuation
- 2002-03-25 JP JP2002576207A patent/JP4205430B2/ja not_active Expired - Fee Related
- 2002-03-25 SK SK1195-2003A patent/SK11952003A3/sk unknown
- 2002-03-25 PL PL02363907A patent/PL363907A1/xx not_active Application Discontinuation
- 2002-03-25 WO PCT/EP2002/003332 patent/WO2002076946A2/en not_active Ceased
- 2002-03-25 CA CA002441599A patent/CA2441599A1/en not_active Abandoned
- 2002-03-25 BR BR0208338-8A patent/BR0208338A/pt not_active IP Right Cessation
- 2002-03-25 KR KR10-2003-7012460A patent/KR20030083755A/ko not_active Ceased
- 2002-03-25 MX MXPA03008754A patent/MXPA03008754A/es not_active Application Discontinuation
- 2002-03-25 US US10/469,756 patent/US7915264B2/en not_active Expired - Fee Related
- 2002-03-25 HU HU0303623A patent/HUP0303623A2/hu unknown
- 2002-03-25 IL IL15781502A patent/IL157815A0/xx unknown
- 2002-03-26 PE PE2002000241A patent/PE20021161A1/es not_active Application Discontinuation
-
2003
- 2003-09-16 NO NO20034122A patent/NO326546B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030083755A (ko) | 2003-10-30 |
| PL363907A1 (en) | 2004-11-29 |
| SK11952003A3 (sk) | 2004-03-02 |
| CN1500089A (zh) | 2004-05-26 |
| JP2004528312A (ja) | 2004-09-16 |
| HUP0303623A2 (hu) | 2004-03-01 |
| RU2003130221A (ru) | 2005-04-10 |
| US7915264B2 (en) | 2011-03-29 |
| NO20034122D0 (no) | 2003-09-16 |
| BR0208338A (pt) | 2004-03-09 |
| US20040138454A1 (en) | 2004-07-15 |
| JP4205430B2 (ja) | 2009-01-07 |
| WO2002076946A3 (en) | 2002-12-27 |
| EP1377576A2 (en) | 2004-01-07 |
| NO326546B1 (no) | 2009-01-05 |
| IL157815A0 (en) | 2004-03-28 |
| PE20021161A1 (es) | 2003-02-21 |
| CZ20032561A3 (cs) | 2003-12-17 |
| MXPA03008754A (es) | 2004-02-18 |
| WO2002076946A2 (en) | 2002-10-03 |
| NO20034122L (no) | 2003-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |