CA2439925C - Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use - Google Patents
Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use Download PDFInfo
- Publication number
- CA2439925C CA2439925C CA2439925A CA2439925A CA2439925C CA 2439925 C CA2439925 C CA 2439925C CA 2439925 A CA2439925 A CA 2439925A CA 2439925 A CA2439925 A CA 2439925A CA 2439925 C CA2439925 C CA 2439925C
- Authority
- CA
- Canada
- Prior art keywords
- hydrogel
- environmentally responsive
- responsive hydrogel
- hydrogels
- monomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 178
- 238000000034 method Methods 0.000 title abstract description 19
- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- 239000000178 monomer Substances 0.000 claims abstract description 56
- 239000008188 pellet Substances 0.000 claims abstract description 28
- 239000004971 Cross linker Substances 0.000 claims abstract description 19
- 239000002245 particle Substances 0.000 claims abstract description 15
- 239000011148 porous material Substances 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 7
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 6
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical group C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 6
- 229920000058 polyacrylate Polymers 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 12
- 229920000642 polymer Polymers 0.000 abstract description 11
- 239000011541 reaction mixture Substances 0.000 abstract description 9
- 238000002513 implantation Methods 0.000 abstract description 7
- 230000007613 environmental effect Effects 0.000 abstract description 3
- -1 filaments Substances 0.000 abstract description 2
- 239000003505 polymerization initiator Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 42
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 35
- 239000000463 material Substances 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 239000002904 solvent Substances 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 235000019441 ethanol Nutrition 0.000 description 10
- 238000011534 incubation Methods 0.000 description 9
- 239000003999 initiator Substances 0.000 description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 8
- 238000004132 cross linking Methods 0.000 description 8
- 230000008961 swelling Effects 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 7
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 6
- 230000005744 arteriovenous malformation Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 206010002329 Aneurysm Diseases 0.000 description 5
- 230000010102 embolization Effects 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 125000002843 carboxylic acid group Chemical group 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229910052697 platinum Inorganic materials 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 3
- 239000011837 N,N-methylenebisacrylamide Substances 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 229940047670 sodium acrylate Drugs 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000005595 deprotonation Effects 0.000 description 2
- 238000010537 deprotonation reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000005865 ionizing radiation Effects 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 230000005588 protonation Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000003894 surgical glue Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
- C08F22/36—Amides or imides
- C08F22/38—Amides
- C08F22/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0457—Semi-solid forms, ointments, gels, hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/804,935 | 2001-03-13 | ||
| US09/804,935 US6878384B2 (en) | 2001-03-13 | 2001-03-13 | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
| PCT/US2002/005988 WO2002071994A1 (en) | 2001-03-13 | 2002-02-28 | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2439925A1 CA2439925A1 (en) | 2002-09-19 |
| CA2439925C true CA2439925C (en) | 2014-01-14 |
Family
ID=25190260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2439925A Expired - Lifetime CA2439925C (en) | 2001-03-13 | 2002-02-28 | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6878384B2 (enExample) |
| EP (3) | EP2363104B1 (enExample) |
| JP (2) | JP4416151B2 (enExample) |
| CN (2) | CN1306916C (enExample) |
| AU (3) | AU2002306605B2 (enExample) |
| BR (1) | BRPI0208034B8 (enExample) |
| CA (1) | CA2439925C (enExample) |
| ES (3) | ES2408014T3 (enExample) |
| WO (1) | WO2002071994A1 (enExample) |
Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014200734B2 (en) * | 2001-03-13 | 2015-11-05 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
| US6878384B2 (en) | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
| AU2002305401A1 (en) * | 2001-05-04 | 2002-11-18 | Concentric Medical | Hydrogel filament vaso-occlusive device |
| WO2003000116A2 (en) * | 2001-06-20 | 2003-01-03 | Microvention, Inc. | Medical devices having full or partial polymer coatings and their methods of manufacture |
| US8252040B2 (en) * | 2001-07-20 | 2012-08-28 | Microvention, Inc. | Aneurysm treatment device and method of use |
| US7572288B2 (en) | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
| BR0307516A (pt) * | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Formas de dosagem de liberação imediata contendo dispersões de uma droga sólida |
| US8425549B2 (en) | 2002-07-23 | 2013-04-23 | Reverse Medical Corporation | Systems and methods for removing obstructive matter from body lumens and treating vascular defects |
| US7551749B2 (en) * | 2002-08-23 | 2009-06-23 | Bose Corporation | Baffle vibration reducing |
| DE10330269A1 (de) * | 2003-07-04 | 2005-01-27 | Instraction Gmbh | System umfassend Effektoren und volumenveränderbare Rezeptoren-modifizierte Elastomere, Verfahren zu ihrer Herstellung und ihrer Verwendung |
| JP2007509716A (ja) * | 2003-10-29 | 2007-04-19 | ジェンティス インコーポレイテッド | 組織工学用の重合可能なエマルション |
| EP1786485A4 (en) * | 2004-02-06 | 2012-05-30 | Georgia Tech Res Inst | CELLULAR IMPLANTATION WITH SURFACE ADHESION |
| CA2558661C (en) | 2004-02-06 | 2012-09-04 | Georgia Tech Research Corporation | Load bearing biocompatible device |
| EP1750619B1 (en) | 2004-05-25 | 2013-07-24 | Covidien LP | Flexible vascular occluding device |
| EP2419048A4 (en) | 2004-05-25 | 2014-04-09 | Covidien Lp | VACCINE PLANTATION FOR ANEURYSMA |
| US9675476B2 (en) | 2004-05-25 | 2017-06-13 | Covidien Lp | Vascular stenting for aneurysms |
| ATE509642T1 (de) * | 2004-09-10 | 2011-06-15 | Stichting Dutch Polymer Inst | Röntgendichte bandscheibenkernprothese |
| US7201918B2 (en) * | 2004-11-16 | 2007-04-10 | Microvention, Inc. | Compositions, systems and methods for treatment of defects in blood vessels |
| US7419486B2 (en) * | 2005-06-15 | 2008-09-02 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Treatment and diagnostic catheters with hydrogel electrodes |
| GB0523999D0 (en) * | 2005-11-25 | 2006-01-04 | Univ Manchester | Microgel particle |
| US7959676B2 (en) * | 2006-02-13 | 2011-06-14 | Lanx, Inc. | Method and apparatus for intervertebral disc support and repair |
| WO2007100556A1 (en) | 2006-02-22 | 2007-09-07 | Ev3 Inc. | Embolic protection systems having radiopaque filter mesh |
| US8377091B2 (en) | 2006-06-15 | 2013-02-19 | Microvention, Inc. | Embolization device constructed from expansile polymer |
| WO2008112826A1 (en) | 2007-03-12 | 2008-09-18 | Board Of Regents, The University Of Texas System | Method and process for the production of multi-coated recognitive and releasing systems |
| US8821899B2 (en) | 2007-03-12 | 2014-09-02 | Board Of Regents, The University Of Texas System | Method and process for the production of multi-coated recognitive and releasing systems |
| US8741316B2 (en) * | 2007-03-12 | 2014-06-03 | Board Of Regents, The University Of Texas System | Highly porous, recognitive polymer systems |
| US8771713B2 (en) | 2007-03-12 | 2014-07-08 | Board Of Regents, The University Of Texas System | Method and process for the production of multi-coated recognitive and releasing systems |
| EP2157937B1 (en) | 2007-06-04 | 2017-03-22 | Sequent Medical, Inc. | Devices for treatment of vascular defects |
| US9023094B2 (en) | 2007-06-25 | 2015-05-05 | Microvention, Inc. | Self-expanding prosthesis |
| CN101903051B (zh) * | 2007-12-21 | 2013-07-31 | 微温森公司 | 用于生物医药用途的水凝胶细丝 |
| US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
| ES2430117T3 (es) | 2008-04-21 | 2013-11-19 | Covidien Lp | Dispositivos embólicos de bola de trenza y sistemas de colocación |
| BRPI0911923B8 (pt) * | 2008-05-02 | 2021-06-22 | Sequent Medical Inc | dispositivo para tratamento de um aneurisma cerebral |
| WO2009140437A1 (en) | 2008-05-13 | 2009-11-19 | Nfocus Neuromedical, Inc. | Braid implant delivery systems |
| US8180076B2 (en) * | 2008-07-31 | 2012-05-15 | Bose Corporation | System and method for reducing baffle vibration |
| EP2172236A1 (en) * | 2008-10-03 | 2010-04-07 | Koninklijke Philips Electronics N.V. | Breast pump system |
| JP2010162063A (ja) * | 2009-01-13 | 2010-07-29 | Japan Health Science Foundation | 塞栓材 |
| JP2012100680A (ja) * | 2009-03-04 | 2012-05-31 | Terumo Corp | 血管内用処置材 |
| JP2010227172A (ja) * | 2009-03-26 | 2010-10-14 | Terumo Corp | 軟組織増大材料 |
| BRPI1014645B1 (pt) | 2009-04-30 | 2020-07-07 | Technip France | método e sistema para compartilhar linhas de amarração |
| US10639396B2 (en) | 2015-06-11 | 2020-05-05 | Microvention, Inc. | Polymers |
| US8409269B2 (en) | 2009-12-21 | 2013-04-02 | Covidien Lp | Procedures for vascular occlusion |
| KR20120090052A (ko) * | 2009-09-24 | 2012-08-16 | 마이크로벤션, 인코포레이티드 | 생물 의학적 사용을 위한 주사가능한 히드로겔 필라멘트 |
| JP5401254B2 (ja) * | 2009-10-13 | 2014-01-29 | 昌典 石原 | 多孔質合成樹脂製造方法および同多孔質合成樹脂製造方法により製造された多孔質合成樹脂材 |
| AU2010313530B2 (en) * | 2009-10-26 | 2015-12-17 | Microvention, Inc. | Embolization device constructed from expansile polymer |
| US20110152993A1 (en) * | 2009-11-05 | 2011-06-23 | Sequent Medical Inc. | Multiple layer filamentary devices or treatment of vascular defects |
| US8337448B2 (en) | 2010-01-29 | 2012-12-25 | Baxter International Inc. | Apparatus for monitoring and controlling peritoneal dialysis |
| EP2613735B1 (en) | 2010-09-10 | 2018-05-09 | Covidien LP | Devices for the treatment of vascular defects |
| US8998947B2 (en) | 2010-09-10 | 2015-04-07 | Medina Medical, Inc. | Devices and methods for the treatment of vascular defects |
| WO2012078678A1 (en) | 2010-12-06 | 2012-06-14 | Tyco Healthcare Group Lp | Vascular remodeling device |
| US9089332B2 (en) | 2011-03-25 | 2015-07-28 | Covidien Lp | Vascular remodeling device |
| WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
| EP2707077B1 (en) | 2011-05-11 | 2017-10-04 | Microvention, Inc. | Device for occluding a lumen |
| AU2012253583B2 (en) | 2011-05-11 | 2014-09-25 | Covidien Lp | Vascular remodeling device |
| EP2757964B1 (en) | 2011-05-26 | 2016-05-04 | Cartiva, Inc. | Tapered joint implant and related tools |
| US9060886B2 (en) | 2011-09-29 | 2015-06-23 | Covidien Lp | Vascular remodeling device |
| US9072620B2 (en) | 2011-11-04 | 2015-07-07 | Covidien Lp | Protuberant aneurysm bridging device deployment method |
| US9011480B2 (en) | 2012-01-20 | 2015-04-21 | Covidien Lp | Aneurysm treatment coils |
| US9011884B2 (en) | 2012-04-18 | 2015-04-21 | Microvention, Inc. | Embolic devices |
| US10350072B2 (en) | 2012-05-24 | 2019-07-16 | Cartiva, Inc. | Tooling for creating tapered opening in tissue and related methods |
| US9452070B2 (en) | 2012-10-31 | 2016-09-27 | Covidien Lp | Methods and systems for increasing a density of a region of a vascular device |
| CN108354645A (zh) | 2012-11-13 | 2018-08-03 | 柯惠有限合伙公司 | 封堵装置 |
| WO2014164357A1 (en) | 2013-03-11 | 2014-10-09 | Microvention, Inc. | Implantable device with adhesive properties |
| WO2014145012A2 (en) | 2013-03-15 | 2014-09-18 | Covidien Lp | Delivery and detachment mechanisms for vascular implants |
| CN105142545B (zh) | 2013-03-15 | 2018-04-06 | 柯惠有限合伙公司 | 闭塞装置 |
| US9955976B2 (en) | 2013-08-16 | 2018-05-01 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| US9078658B2 (en) | 2013-08-16 | 2015-07-14 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| US9963556B2 (en) | 2013-09-18 | 2018-05-08 | Senseonics, Incorporated | Critical point drying of hydrogels in analyte sensors |
| CA2923753C (en) | 2013-09-19 | 2021-10-12 | Terumo Corporation | Polymer particles |
| BR112016005768B1 (pt) * | 2013-09-19 | 2021-09-21 | Microvention, Inc | Películas de polímero |
| EP3065719A4 (en) | 2013-11-08 | 2017-08-09 | Terumo Corporation | Polymer particles |
| US9795400B2 (en) | 2013-11-13 | 2017-10-24 | Covidien Lp | Galvanically assisted attachment of medical devices to thrombus |
| JP6456969B2 (ja) * | 2014-02-21 | 2019-01-23 | マサチューセッツ インスティテュート オブ テクノロジー | 膨張顕微鏡法 |
| JP6645979B2 (ja) * | 2014-03-07 | 2020-02-14 | エンドーロジックス インコーポレイテッド | ヒドロゲルを形成する改善された方法およびその材料 |
| WO2015153996A1 (en) | 2014-04-03 | 2015-10-08 | Micro Vention, Inc. | Embolic devices |
| US9629635B2 (en) | 2014-04-14 | 2017-04-25 | Sequent Medical, Inc. | Devices for therapeutic vascular procedures |
| US9713475B2 (en) | 2014-04-18 | 2017-07-25 | Covidien Lp | Embolic medical devices |
| CN110433326A (zh) | 2014-04-29 | 2019-11-12 | 微仙美国有限公司 | 包含活性剂的聚合物 |
| WO2015167751A1 (en) | 2014-04-29 | 2015-11-05 | Microvention, Inc. | Polymers |
| JP2017515567A (ja) | 2014-05-12 | 2017-06-15 | トマス，ジェフリー，イー． | 光子活性化ゲルでコーティングされた頭蓋内ステントおよび塞栓コイル |
| BR112017000813B1 (pt) | 2014-07-17 | 2021-03-16 | The Regents Of The University Of California | sistemas de gel microporoso, usos de uma pluralidade de partículas de microgel em uma solução aquosa e um agente de recozimento, de camadas de sequestrantes covalentemente estabilizados de partículas de microgel, e de um sequestrante covalentemente estabilizado de partículas de microgel com espaços intersticiais, bem como método para a preparação de partículas de microgel |
| US9814466B2 (en) | 2014-08-08 | 2017-11-14 | Covidien Lp | Electrolytic and mechanical detachment for implant delivery systems |
| TW201625754A (zh) * | 2014-11-21 | 2016-07-16 | 艾倫塔斯有限公司 | 單一成份、儲存穩定、可硬化之聚矽氧組成物 |
| US9907880B2 (en) | 2015-03-26 | 2018-03-06 | Microvention, Inc. | Particles |
| AU2016243659B2 (en) | 2015-03-31 | 2020-04-23 | Cartiva, Inc. | Hydrogel implants with porous materials and methods |
| WO2016161026A1 (en) | 2015-03-31 | 2016-10-06 | Cartiva, Inc. | Carpometacarpal (cmc) implants and methods |
| US10526649B2 (en) | 2015-04-14 | 2020-01-07 | Massachusetts Institute Of Technology | Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information |
| US11408890B2 (en) | 2015-04-14 | 2022-08-09 | Massachusetts Institute Of Technology | Iterative expansion microscopy |
| US10059990B2 (en) | 2015-04-14 | 2018-08-28 | Massachusetts Institute Of Technology | In situ nucleic acid sequencing of expanded biological samples |
| WO2017023903A1 (en) * | 2015-08-03 | 2017-02-09 | President And Fellows Of Harvard College | Phase-transforming and switchable metamaterials |
| WO2017027368A1 (en) | 2015-08-07 | 2017-02-16 | Massachusetts Institute Of Technology | Protein retention expansion microscopy |
| CN108474029B (zh) | 2015-08-07 | 2021-07-23 | 麻省理工学院 | 通过扩展显微法的蛋白质和核酸的纳米级成像 |
| US10478194B2 (en) | 2015-09-23 | 2019-11-19 | Covidien Lp | Occlusive devices |
| US10314593B2 (en) | 2015-09-23 | 2019-06-11 | Covidien Lp | Occlusive devices |
| EP3373870A4 (en) | 2015-11-12 | 2019-07-10 | University Of Virginia Patent Foundation | COMPOSITIONS AND METHODS FOR VAS OCCLUSAL CONSUMER PREVENTION AND THEIR REVERSAL |
| WO2017142879A1 (en) | 2016-02-16 | 2017-08-24 | The Regents Of The University Of California | Methods for immune system modulation with microporous annealed particle gels |
| US10893869B2 (en) | 2016-03-24 | 2021-01-19 | Covidien Lp | Thin wall constructions for vascular flow diversion |
| US10828039B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment for implantable devices |
| US10828037B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment with fluid electrical connection |
| US11051822B2 (en) | 2016-06-28 | 2021-07-06 | Covidien Lp | Implant detachment with thermal activation |
| US20180028715A1 (en) | 2016-07-27 | 2018-02-01 | Contraline, Inc. | Carbon-based compositions useful for occlusive medical devices and methods of making and using them |
| US10478195B2 (en) | 2016-08-04 | 2019-11-19 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| CA3038642C (en) | 2016-09-28 | 2021-11-02 | Terumo Corporation | Polymer particles comprising polymerizable pharmaceutical agents |
| US20180206851A1 (en) * | 2016-10-19 | 2018-07-26 | Daniel E. Walzman | Hydrogel intrasaccular occlusion device |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| US11931928B2 (en) | 2016-12-29 | 2024-03-19 | Evonik Superabsorber Llc | Continuous strand superabsorbent polymerization |
| CA3051055A1 (en) | 2016-12-29 | 2018-07-26 | Tempo Therapeutics, Inc. | Methods and systems for treating a site of a medical implant |
| WO2018136856A1 (en) | 2017-01-23 | 2018-07-26 | Massachusetts Institute Of Technology | Multiplexed signal amplified fish via splinted ligation amplification and sequencing |
| US11385481B1 (en) | 2017-02-01 | 2022-07-12 | Ram Pattikonda | Advanced dynamic focus eyewear |
| WO2018157074A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for diagnosing neoplastic lesions |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| CN110709110B (zh) * | 2017-04-05 | 2023-05-16 | 赛特博恩医疗有限公司 | 性质改变的植入物 |
| CN107158560A (zh) * | 2017-04-27 | 2017-09-15 | 清华大学 | 基于水凝胶溶胀特性的可控自变形神经微电极 |
| US11180804B2 (en) | 2017-07-25 | 2021-11-23 | Massachusetts Institute Of Technology | In situ ATAC sequencing |
| US10675036B2 (en) | 2017-08-22 | 2020-06-09 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| WO2019082991A1 (ja) * | 2017-10-25 | 2019-05-02 | メディギア・インターナショナル株式会社 | 生体分解性及び生体代謝性の腫瘍封止剤 |
| US11873374B2 (en) | 2018-02-06 | 2024-01-16 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| US11065136B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US11065009B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| WO2020013833A1 (en) | 2018-07-13 | 2020-01-16 | Massachusetts Institute Of Technology | Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm) |
| US10912569B2 (en) | 2018-08-22 | 2021-02-09 | Covidien Lp | Aneurysm treatment coils and associated systems and methods of use |
| US10905432B2 (en) | 2018-08-22 | 2021-02-02 | Covidien Lp | Aneurysm treatment coils and associated systems and methods of use |
| US11730485B2 (en) | 2018-12-17 | 2023-08-22 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| CN111393563B (zh) * | 2019-01-02 | 2023-04-07 | 湖南工业大学 | 一种温敏性水凝胶的制备方法及监测模具 |
| CA3130889A1 (en) | 2019-02-22 | 2020-08-27 | Massachusetts Institute Of Technology | Iterative direct expansion microscopy |
| CN111686310B (zh) * | 2019-03-11 | 2022-03-29 | 国家纳米科学中心 | 一种抗菌导尿管及其制备方法和应用 |
| EP3908208A4 (en) | 2019-03-15 | 2022-10-19 | Sequent Medical, Inc. | FILAMENTAL DEVICES WITH A FLEXIBLE CONNECTION FOR TREATMENT OF VASCULAR DEFECTS |
| US11317921B2 (en) | 2019-03-15 | 2022-05-03 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| EP3908209A4 (en) | 2019-03-15 | 2022-10-19 | Sequent Medical, Inc. | FIBROUS DEVICES FOR TREATMENT OF VASCULAR DEFECTS |
| EP4054440B1 (en) | 2019-11-04 | 2024-06-05 | Covidien LP | Manufacturing method of devices for treatment of intracranial aneurysms |
| US12265004B2 (en) | 2019-11-05 | 2025-04-01 | Massachusetts Institute Of Technology | Membrane probes for expansion microscopy |
| US11802822B2 (en) | 2019-12-05 | 2023-10-31 | Massachusetts Institute Of Technology | Multiplexed expansion (MultiExM) pathology |
| US20210282789A1 (en) | 2020-03-11 | 2021-09-16 | Microvention, Inc. | Multiple layer devices for treatment of vascular defects |
| WO2021183793A2 (en) | 2020-03-11 | 2021-09-16 | Microvention, Inc. | Devices for treatment of vascular defects |
| US12070220B2 (en) | 2020-03-11 | 2024-08-27 | Microvention, Inc. | Devices having multiple permeable shells for treatment of vascular defects |
| CN111333866B (zh) * | 2020-03-20 | 2023-03-24 | 浙江理工大学 | 一种单层水凝胶、制备方法及用作柔性抓手的应用 |
| US11931041B2 (en) | 2020-05-12 | 2024-03-19 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| CN112300413B (zh) * | 2020-12-29 | 2021-04-09 | 北京泰杰伟业科技有限公司 | 一种超细均匀的丙烯酰胺类聚合物水凝胶丝的制备方法及应用 |
| US12364793B2 (en) | 2021-03-16 | 2025-07-22 | Covidien Lp | Injectable biopolymer compositions and associated systems and methods |
| US12351955B2 (en) * | 2021-05-25 | 2025-07-08 | Technische Universitat Dresden | Stimulus-responsive mesh |
| US12446891B2 (en) | 2021-08-30 | 2025-10-21 | Microvention, Inc. | Devices for treatment of vascular defects |
| CN114561237B (zh) * | 2022-04-19 | 2022-10-28 | 中国科学院兰州化学物理研究所 | 一种剪切响应性水基凝胶润滑剂的制备方法 |
| CN115746360B (zh) * | 2022-11-24 | 2023-12-12 | 无锡学院 | 一种间隙可调的柔性表面增强拉曼散射基底及其制备方法和应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6005161A (en) | 1986-01-28 | 1999-12-21 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
| US4990138A (en) * | 1989-07-18 | 1991-02-05 | Baxter International Inc. | Catheter apparatus, and compositions useful for producing same |
| US5635482A (en) | 1989-08-14 | 1997-06-03 | The Regents Of The University Of California | Synthetic compounds and compositions with enhanced cell binding |
| WO1991004732A1 (en) * | 1989-10-03 | 1991-04-18 | Advanced Polymer Systems, Inc. | Erodible macroporous hydrogel particles and preparation thereof |
| CA2080224A1 (en) | 1990-04-18 | 1991-10-19 | Jindrich Kopecek | Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting ph-dependent swelling |
| US5226902A (en) | 1991-07-30 | 1993-07-13 | University Of Utah | Pulsatile drug delivery device using stimuli sensitive hydrogel |
| US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
| US5447727A (en) * | 1992-10-14 | 1995-09-05 | The Dow Chemical Company | Water-absorbent polymer having improved properties |
| US5554147A (en) | 1994-02-01 | 1996-09-10 | Caphco, Inc. | Compositions and devices for controlled release of active ingredients |
| US5651979A (en) * | 1995-03-30 | 1997-07-29 | Gel Sciences, Inc. | Apparatus and method for delivering a biologically active compound into a biological environment |
| US5750585A (en) | 1995-04-04 | 1998-05-12 | Purdue Research Foundation | Super absorbent hydrogel foams |
| WO1997022365A1 (en) | 1995-12-19 | 1997-06-26 | Bracco Research S.A. | Compositions comprising tricodobenzene polymers for imaging the gastrointestinal tract |
| US5863551A (en) * | 1996-10-16 | 1999-01-26 | Organogel Canada Ltee | Implantable polymer hydrogel for therapeutic uses |
| WO1998043615A1 (en) | 1997-04-02 | 1998-10-08 | Purdue Research Foundation | Method for oral delivery of proteins |
| US6224893B1 (en) * | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
| US6271278B1 (en) * | 1997-05-13 | 2001-08-07 | Purdue Research Foundation | Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties |
| US5891192A (en) | 1997-05-22 | 1999-04-06 | The Regents Of The University Of California | Ion-implanted protein-coated intralumenal implants |
| US6077880A (en) * | 1997-08-08 | 2000-06-20 | Cordis Corporation | Highly radiopaque polyolefins and method for making the same |
| CN1714783A (zh) * | 1998-03-06 | 2006-01-04 | 生物领域医疗公司 | 用于组织膨胀和治疗的可植入颗粒 |
| US6165193A (en) * | 1998-07-06 | 2000-12-26 | Microvention, Inc. | Vascular embolization with an expansible implant |
| KR20000012970A (ko) | 1998-08-03 | 2000-03-06 | 김효근 | 썰폰아마이드기를 포함하는 ph 민감성 고분자 및 그의 제조방법 |
| JP4428729B2 (ja) * | 1998-08-13 | 2010-03-10 | 株式会社日本触媒 | 水膨潤性架橋重合体組成物およびその製法 |
| US5952232A (en) | 1998-09-17 | 1999-09-14 | Rothman; James Edward | Expandible microparticle intracellular delivery system |
| US6187024B1 (en) | 1998-11-10 | 2001-02-13 | Target Therapeutics, Inc. | Bioactive coating for vaso-occlusive devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| US6371904B1 (en) * | 1998-12-24 | 2002-04-16 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
| EP1031354A3 (en) | 1999-01-19 | 2003-02-05 | Rohm And Haas Company | Polymeric MRI Contrast agents |
| US6663607B2 (en) | 1999-07-12 | 2003-12-16 | Scimed Life Systems, Inc. | Bioactive aneurysm closure device assembly and kit |
| US7291673B2 (en) | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US6506408B1 (en) * | 2000-07-13 | 2003-01-14 | Scimed Life Systems, Inc. | Implantable or insertable therapeutic agent delivery device |
| US6878384B2 (en) * | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
| EP2319430B1 (en) | 2001-05-29 | 2013-11-13 | Microvention, Inc. | Vascular embolization device and method of manufacture |
| US20030014075A1 (en) * | 2001-07-16 | 2003-01-16 | Microvention, Inc. | Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation |
| EP1460982A4 (en) | 2001-11-16 | 2010-04-14 | Biocure Inc | METHODS FOR INITIATING IN SITU FORMATION OF HYDROGELS |
| AU2003234159A1 (en) | 2002-04-22 | 2003-11-03 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
| CN101919722A (zh) | 2002-07-31 | 2010-12-22 | 微温森公司 | 三部件同轴的血管闭塞装置 |
| US20050119687A1 (en) | 2003-09-08 | 2005-06-02 | Dacey Ralph G.Jr. | Methods of, and materials for, treating vascular defects with magnetically controllable hydrogels |
| US8377091B2 (en) | 2006-06-15 | 2013-02-19 | Microvention, Inc. | Embolization device constructed from expansile polymer |
-
2001
- 2001-03-13 US US09/804,935 patent/US6878384B2/en not_active Expired - Lifetime
-
2002
- 2002-02-28 ES ES10188595T patent/ES2408014T3/es not_active Expired - Lifetime
- 2002-02-28 JP JP2002570954A patent/JP4416151B2/ja not_active Expired - Lifetime
- 2002-02-28 ES ES02750563.5T patent/ES2478992T3/es not_active Expired - Lifetime
- 2002-02-28 EP EP10188595.2A patent/EP2363104B1/en not_active Expired - Lifetime
- 2002-02-28 CA CA2439925A patent/CA2439925C/en not_active Expired - Lifetime
- 2002-02-28 EP EP02750563.5A patent/EP1372553B1/en not_active Expired - Lifetime
- 2002-02-28 BR BRPI0208034A patent/BRPI0208034B8/pt not_active IP Right Cessation
- 2002-02-28 CN CNB028063848A patent/CN1306916C/zh not_active Expired - Lifetime
- 2002-02-28 WO PCT/US2002/005988 patent/WO2002071994A1/en not_active Ceased
- 2002-02-28 ES ES10188630T patent/ES2390605T3/es not_active Expired - Lifetime
- 2002-02-28 EP EP10188630A patent/EP2308431B1/en not_active Expired - Lifetime
- 2002-02-28 CN CNA2007100077925A patent/CN101024729A/zh active Pending
- 2002-02-28 AU AU2002306605A patent/AU2002306605B2/en not_active Expired
-
2005
- 2005-03-24 US US11/090,806 patent/US8231890B2/en not_active Expired - Lifetime
-
2007
- 2007-09-07 AU AU2007216682A patent/AU2007216682B2/en not_active Ceased
-
2009
- 2009-09-10 AU AU2009213041A patent/AU2009213041A1/en not_active Abandoned
- 2009-10-01 JP JP2009229839A patent/JP5154529B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-19 US US13/527,485 patent/US8465779B2/en not_active Expired - Fee Related
-
2013
- 2013-05-20 US US13/898,250 patent/US8734834B2/en not_active Expired - Fee Related
-
2014
- 2014-04-16 US US14/254,661 patent/US20140256837A1/en not_active Abandoned
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