CA2434518A1 - Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-methyl-butyrylamino)-propionique (hmbpa) - Google Patents

Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-methyl-butyrylamino)-propionique (hmbpa) Download PDF

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Publication number
CA2434518A1
CA2434518A1 CA002434518A CA2434518A CA2434518A1 CA 2434518 A1 CA2434518 A1 CA 2434518A1 CA 002434518 A CA002434518 A CA 002434518A CA 2434518 A CA2434518 A CA 2434518A CA 2434518 A1 CA2434518 A1 CA 2434518A1
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CA
Canada
Prior art keywords
hmbpa
microorganism
gene
production
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002434518A
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English (en)
Inventor
Theron Hermann
Thomas A. Patterson
Janice G. Pero
Rogers R. Yocum
Kai-Uwe Baldenius
Christine Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2434518A1 publication Critical patent/CA2434518A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des procédés de production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique ("HMBPA") et d'.alpha.-hydroxyisovalérate (".alpha.-HIV") en utilisant des micro-organismes agissant comme des enzymes biosynthétiques modifiés de pantothénate. L'invention concerne également des micro-organismes de recombinaison et des états permettant leur culture. L'invention concerne enfin des compositions incluant le HMBPA ainsi que des compositions incluant le .alpha.-HIV.
CA002434518A 2001-01-19 2002-01-19 Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-methyl-butyrylamino)-propionique (hmbpa) Abandoned CA2434518A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26305301P 2001-01-19 2001-01-19
US60/263,053 2001-01-19
PCT/US2002/001887 WO2002057476A2 (fr) 2001-01-19 2002-01-19 Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa)

Publications (1)

Publication Number Publication Date
CA2434518A1 true CA2434518A1 (fr) 2002-07-25

Family

ID=23000176

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002434518A Abandoned CA2434518A1 (fr) 2001-01-19 2002-01-19 Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-methyl-butyrylamino)-propionique (hmbpa)

Country Status (7)

Country Link
EP (1) EP1377662A2 (fr)
JP (1) JP2005503758A (fr)
KR (1) KR20040004495A (fr)
CN (1) CN1496400A (fr)
AU (1) AU2002241944A1 (fr)
CA (1) CA2434518A1 (fr)
WO (1) WO2002057476A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012812A (es) 2002-07-03 2005-02-24 Basf Ag Microorganismos y proceso para la produccion aumentada de pantotenato.
CN101448950B (zh) 2006-05-16 2014-02-12 帝斯曼知识产权资产管理有限公司 用于生产泛醇的工艺
TW202122075A (zh) * 2019-12-11 2021-06-16 大江生醫股份有限公司 乳酸菌的代謝產物及其用於製備血管保健組合物之用途
CN112126666B (zh) * 2020-09-22 2022-04-08 廊坊梅花生物技术开发有限公司 核苷高产菌及其构建方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907567B4 (de) * 1999-02-22 2007-08-09 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen Herstellung von L-Valin
CN100543143C (zh) * 2001-01-19 2009-09-23 巴斯福股份公司 提高泛酸产量的方法

Also Published As

Publication number Publication date
EP1377662A2 (fr) 2004-01-07
KR20040004495A (ko) 2004-01-13
WO2002057476A2 (fr) 2002-07-25
JP2005503758A (ja) 2005-02-10
CN1496400A (zh) 2004-05-12
WO2002057476A9 (fr) 2003-04-10
AU2002241944A1 (en) 2002-07-30
WO2002057476A3 (fr) 2003-10-30

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