WO2002057476A3 - Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa) - Google Patents

Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa) Download PDF

Info

Publication number
WO2002057476A3
WO2002057476A3 PCT/US2002/001887 US0201887W WO02057476A3 WO 2002057476 A3 WO2002057476 A3 WO 2002057476A3 US 0201887 W US0201887 W US 0201887W WO 02057476 A3 WO02057476 A3 WO 02057476A3
Authority
WO
WIPO (PCT)
Prior art keywords
hmbpa
microorganisms
butyrylamino
hydroxy
methyl
Prior art date
Application number
PCT/US2002/001887
Other languages
English (en)
Other versions
WO2002057476A9 (fr
WO2002057476A2 (fr
Inventor
Theron Hermann
Thomas A Patterson
Janice G Pero
Rogers Yocum R
Kai-Uwe Baldenius
Christine Beck
Original Assignee
Basf Ag
Theron Hermann
Thomas A Patterson
Janice G Pero
Rogers Yocum R
Kai-Uwe Baldenius
Christine Beck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Theron Hermann, Thomas A Patterson, Janice G Pero, Rogers Yocum R, Kai-Uwe Baldenius, Christine Beck filed Critical Basf Ag
Priority to AU2002241944A priority Critical patent/AU2002241944A1/en
Priority to CA002434518A priority patent/CA2434518A1/fr
Priority to JP2002558528A priority patent/JP2005503758A/ja
Priority to US10/466,642 priority patent/US20040048343A1/en
Priority to KR20037009570A priority patent/KR20040004495A/ko
Priority to EP02707543A priority patent/EP1377662A2/fr
Publication of WO2002057476A2 publication Critical patent/WO2002057476A2/fr
Publication of WO2002057476A9 publication Critical patent/WO2002057476A9/fr
Publication of WO2002057476A3 publication Critical patent/WO2002057476A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des procédés de production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique ('HMBPA') et d'α-hydroxyisovalérate ('α-HIV') en utilisant des micro-organismes agissant comme des enzymes biosynthétiques modifiés de pantothénate. L'invention concerne également des micro-organismes de recombinaison et des états permettant leur culture. L'invention concerne enfin des compositions incluant le HMBPA ainsi que des compositions incluant le α-HIV.
PCT/US2002/001887 2001-01-19 2002-01-19 Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa) WO2002057476A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002241944A AU2002241944A1 (en) 2001-01-19 2002-01-19 Methods and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
CA002434518A CA2434518A1 (fr) 2001-01-19 2002-01-19 Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-methyl-butyrylamino)-propionique (hmbpa)
JP2002558528A JP2005503758A (ja) 2001-01-19 2002-01-19 ３−（２−ヒドロキシ−３−メチル−ブチリルアミノ）−プロピオン酸（ｈｍｂｐａ）の製造方法及び微生物
US10/466,642 US20040048343A1 (en) 2002-01-19 2002-01-19 Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
KR20037009570A KR20040004495A (ko) 2001-01-19 2002-01-19 3-(2-히드록시-3-메틸-부티릴아미노)-프로피온산(ｈｍｂｐａ)의 제조 방법 및 이를 위한 미생물
EP02707543A EP1377662A2 (fr) 2001-01-19 2002-01-19 Procedes et micro-organismes destines a la production d'acide 3-(2-hydroxy-3-m thyl-butyrylamino)-propionique (hmbpa)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26305301P 2001-01-19 2001-01-19
US60/263,053 2001-01-19

Publications (3)

Publication Number Publication Date
WO2002057476A2 WO2002057476A2 (fr) 2002-07-25
WO2002057476A9 WO2002057476A9 (fr) 2003-04-10
WO2002057476A3 true WO2002057476A3 (fr) 2003-10-30

Family

ID=23000176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/001887 WO2002057476A2 (fr) 2001-01-19 2002-01-19 Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa)

Country Status (7)

Country Link
EP (1) EP1377662A2 (fr)
JP (1) JP2005503758A (fr)
KR (1) KR20040004495A (fr)
CN (1) CN1496400A (fr)
AU (1) AU2002241944A1 (fr)
CA (1) CA2434518A1 (fr)
WO (1) WO2002057476A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012812A (es) 2002-07-03 2005-02-24 Basf Ag Microorganismos y proceso para la produccion aumentada de pantotenato.
DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
TW202122075A (zh) * 2019-12-11 2021-06-16 大江生醫股份有限公司 乳酸菌的代謝產物及其用於製備血管保健組合物之用途
CN112126666B (zh) * 2020-09-22 2022-04-08 廊坊梅花生物技术开发有限公司 核苷高产菌及其构建方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907567A1 (de) * 1999-02-22 2000-08-24 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von L-Valin
WO2002057474A2 (fr) * 2001-01-19 2002-07-25 Basf Aktiengesellschaft Production amelioree de pantothenate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907567A1 (de) * 1999-02-22 2000-08-24 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von L-Valin
WO2002057474A2 (fr) * 2001-01-19 2002-07-25 Basf Aktiengesellschaft Production amelioree de pantothenate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GORDON E M ET AL: "SYNTHESIS OF SUBSTRATED-BASED INHIBITORS OF HMG COA REDUCTASE (II)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 1, no. 3, 1991, pages 161 - 164, XP000940927, ISSN: 0960-894X *
SCHUMMER A ET AL: "POLYFUNCTIONAL (R)-2-HYDROXYCARBOXYLIC ACIDS BY REDUCTION OF 2-OXO ACIDS WITH HYDROGEN GAS OR FORMATE AND RESTING CELLS OF PROTEUS VULGARIS", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 47, no. 43, 1991, pages 9019 - 9034, XP000196414, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
WO2002057476A9 (fr) 2003-04-10
JP2005503758A (ja) 2005-02-10
EP1377662A2 (fr) 2004-01-07
CN1496400A (zh) 2004-05-12
CA2434518A1 (fr) 2002-07-25
KR20040004495A (ko) 2004-01-13
AU2002241944A1 (en) 2002-07-30
WO2002057476A2 (fr) 2002-07-25

Similar Documents

Publication Publication Date Title
WO1999057325A3 (fr) Melanges d'enzymes
MXPA04000622A (es) Pirazolilcarboxanilidas como funguicidas.
EP1360314A4 (fr) Milieu chimiquement defini pour cellules mammaliennes cultivees
AU691714B2 (en) Bacillus-derived transglutaminase
WO2002057474A3 (fr) Production amelioree de pantothenate
AU5630999A (en) Endofucanases and method using same for preparing fuco-oligosaccharides from fucanes, bacterium producing endofucanases and uses of fuco-oligosaccharides for plant protection
AU2003258187A1 (en) Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
WO2000008196A3 (fr) Urate oxydase
AU2003275613A1 (en) Novel fructosyl peptide oxidase and utilization thereof
AU1430097A (en) Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
WO2001016285A3 (fr) Nouvelles proteases et leurs variants
WO2003060144A3 (fr) Compositions de polymerases d'adn de haute fidelite et utilisations leur convenant
WO2002061108A3 (fr) Micro-organismes et procedes de production amelioree de pantothenate
WO2002012530A8 (fr) Production d'acide 3-hydroxycarboxylique et utilisation dans des polymeres ramifies
WO2001062938A3 (fr) Oxydase de galactose de variant, acide nucleique codant pour cette enzyme et techniques d'utilisation de celle-ci
WO2004005525A3 (fr) Micro-organismes et procedes de production amelioree de pantothenate
EP1288931A3 (fr) Article d'enregistrement optique
WO2002057476A3 (fr) Procédés et micro-organismes destinés à la production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique (hmbpa)
MXPA02001721A (es) Procedimiento para la preparacion de o-acetil-l-serina por fermentacion.
WO2000004051A3 (fr) Promoteur de facteur de differenciation de croissance et ses utilisations
EP0896057A3 (fr) D-aminoacylase
AU2002316575A1 (en) Microorganisms and processes for enhanced production of pantothenate
AU2003273521A1 (en) Production method of iturin a and its homologues
WO2001042436A3 (fr) Genes impliques dans la voie de degradation de la cyclododecanone
WO2002022834A3 (fr) Procedes permettant de produire des cellules et des animaux comprenant la modification d'un gene cible et compositions associees

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 02803856.8

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
COP Corrected version of pamphlet

Free format text: PAGES 1/11-11/11, DRAWINGS, REPLACED BY NEW PAGES 1/11-11/11; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWE Wipo information: entry into national phase

Ref document number: 2002707543

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2434518

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002558528

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 10466642

Country of ref document: US

Ref document number: 1020037009570

Country of ref document: KR

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002707543

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020037009570

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 2002707543

Country of ref document: EP