CA2412270A1 - Pyrrole derivatives for treating aids - Google Patents

Pyrrole derivatives for treating aids Download PDF

Info

Publication number
CA2412270A1
CA2412270A1 CA002412270A CA2412270A CA2412270A1 CA 2412270 A1 CA2412270 A1 CA 2412270A1 CA 002412270 A CA002412270 A CA 002412270A CA 2412270 A CA2412270 A CA 2412270A CA 2412270 A1 CA2412270 A1 CA 2412270A1
Authority
CA
Canada
Prior art keywords
methyl
isopropyl
pyridyl
pyrrole
dichlorophenylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002412270A
Other languages
English (en)
French (fr)
Inventor
Brian William Dymock
Philip Stephen Jones
John Herbert Merrett
Martin John Parratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2412270A1 publication Critical patent/CA2412270A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA002412270A 2000-07-04 2001-04-30 Pyrrole derivatives for treating aids Abandoned CA2412270A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016453.3 2000-07-04
GBGB0016453.3A GB0016453D0 (en) 2000-07-04 2000-07-04 Pyrrole derivatives
PCT/EP2001/004832 WO2002002524A1 (en) 2000-07-04 2001-04-30 Pyrrole derivatives for treating aids

Publications (1)

Publication Number Publication Date
CA2412270A1 true CA2412270A1 (en) 2002-01-10

Family

ID=9895031

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002412270A Abandoned CA2412270A1 (en) 2000-07-04 2001-04-30 Pyrrole derivatives for treating aids

Country Status (17)

Country Link
US (1) US6737429B2 (enExample)
EP (1) EP1301481A1 (enExample)
JP (1) JP2004502674A (enExample)
KR (1) KR100549884B1 (enExample)
CN (1) CN1440385A (enExample)
AR (1) AR028602A1 (enExample)
AU (2) AU2001263874B2 (enExample)
BR (1) BR0112241A (enExample)
CA (1) CA2412270A1 (enExample)
EC (1) ECSP014109A (enExample)
GB (1) GB0016453D0 (enExample)
GT (1) GT200100111A (enExample)
MX (1) MXPA02012409A (enExample)
PA (1) PA8516201A1 (enExample)
PE (1) PE20020269A1 (enExample)
UY (1) UY26720A1 (enExample)
WO (1) WO2002002524A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1405849A1 (en) * 2002-10-04 2004-04-07 Corning Incorporated Halogenated styrene compounds and low-absorption-loss polymers obtainable therefrom
CA2551602C (en) * 2003-12-26 2013-03-26 Masatoshi Hagiwara Methods for controlling sr protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control sr protein activity
US8048909B2 (en) 2004-09-30 2011-11-01 Takeda Pharmaceutical Company Limited Proton pump inhibitors
TW200628446A (en) * 2004-12-14 2006-08-16 Takeda Pharmaceuticals Co Substituted pyrrole derivative
WO2006072833A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
US7977488B2 (en) 2005-08-30 2011-07-12 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
JP2010505834A (ja) * 2006-10-06 2010-02-25 メルク エンド カムパニー インコーポレーテッド 非ヌクレオシド系逆転写酵素阻害剤
WO2008058287A1 (en) * 2006-11-10 2008-05-15 Syndax Pharmaceuticals, Inc. COMBINATION OF ERα+ LIGANDS AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
WO2009015180A2 (en) * 2007-07-23 2009-01-29 Syndax Pharmaceuticals, Inc. Novel compounds and methods of using them
SG185313A1 (en) * 2007-10-16 2012-11-29 Nikon Corp Illumination optical system, exposure apparatus, and device manufacturing method
US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
KR101629181B1 (ko) 2008-08-27 2016-06-13 다케다 야쿠힌 고교 가부시키가이샤 피롤 화합물
GB0823001D0 (en) * 2008-12-17 2009-01-28 Syngenta Participations Ag Thiophene,furan and pyrrole derivatives with plant growth regulating properties
CN101775011B (zh) * 2009-01-13 2013-07-31 中国人民解放军军事医学科学院毒物药物研究所 N-取代苯基-3-甲烯杂环芳烃-2,5-二甲基吡咯类化合物及其抗hiv/aids的应用
CN114727987A (zh) * 2019-11-19 2022-07-08 纽约血库公司 具有hiv治疗活性的经取代杂环化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644631A (en) * 1969-05-13 1972-02-22 Endo Lab Therapeutic methods utilizing aryl pyrrol-3-yl ketones
US4282242A (en) * 1980-03-07 1981-08-04 Pfizer Inc. Antidiabetic pyrrolecarboxylic acids
US4347186A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
BR9307664A (pt) * 1992-12-17 1999-06-29 Pfizer Pirazóis substituídos como antagonistas
CA2192208C (en) * 1994-06-06 2002-09-10 Pfizer Limited Substituted pyrazoles
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
US6417202B1 (en) * 1996-07-11 2002-07-09 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin-and TNF antagonists
DE19963174A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Substituierte Pyrrol-Mannichbasen

Also Published As

Publication number Publication date
GT200100111A (es) 2002-03-18
UY26720A1 (es) 2001-11-30
WO2002002524A1 (en) 2002-01-10
AU6387401A (en) 2002-01-14
EP1301481A1 (en) 2003-04-16
GB0016453D0 (en) 2000-08-23
JP2004502674A (ja) 2004-01-29
KR100549884B1 (ko) 2006-02-06
MXPA02012409A (es) 2003-04-25
US20020032221A1 (en) 2002-03-14
PE20020269A1 (es) 2002-04-08
US6737429B2 (en) 2004-05-18
KR20030014321A (ko) 2003-02-15
CN1440385A (zh) 2003-09-03
BR0112241A (pt) 2003-06-24
ECSP014109A (es) 2002-02-25
PA8516201A1 (es) 2002-07-30
AU2001263874B2 (en) 2006-10-19
AR028602A1 (es) 2003-05-14

Similar Documents

Publication Publication Date Title
US8933105B2 (en) Pyrrole compounds
CA2412270A1 (en) Pyrrole derivatives for treating aids
ES2402362T3 (es) Inhibidores de la bomba de protones
ES2391757T3 (es) Derivados de 1-H-pirrol sustituidos con 1-heterociclilsulfonilo, 2-aminometilo, 5-heteroarilo como inhibidores de la secreción de ácido
TWI232216B (en) Prostaglandin endoperoxide H synthase biosynthesis inhibitors
KR101559597B1 (ko) ５―원 헤테로시클릭 화합물
WO2003037895A1 (en) 4-(6-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors
US20090156642A1 (en) 5-Membered heterocyclic compound
JP2010502617A (ja) 抗菌物質として有用なヒダントイン誘導体
WO2005014543A1 (ja) 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
EP1401826B1 (en) Pyrazole derivatives as hiv reverse transcriptase inhibitors
AU2001263874A1 (en) Pyrrole derivatives for treating aids
AU2010302572A1 (en) New histone deacetylase inhibitors based simultaneously on trisubstituted 1H-pyrroles and aromatic and heteroaromatic spacers
AU2002325221A1 (en) Pyrazole Derivatives as HIV Reverse Transcriptase Inhibitors
JPH09509925A (ja) インドールの新規な四置換誘導体、それらの製造法、得られる新規な中間体、それらの薬剤としての用途及びそれらを含有する製薬組成物
JP2008545756A (ja) 癌化学療法剤として有用な１−メチル−１ｈ−ピラゾール−４−カルボキサミド類
CA2858164A1 (en) Pyridone derivative and pharmaceutical containing same
CN101208328B (zh) 包含饱和连接基团的杂芳基取代的酰胺以及它们作为药物的用途
US6908940B2 (en) Imidazole compounds and their use as adenosine deaminase inhibitors
SK2312000A3 (en) Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors
HK1088304A1 (zh) 嘧啶酮衍生物作为治疗药物治疗急性和慢性炎性、缺血性和重建性病变
HK1088304B (en) Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued