KR100549884B1 - 에이즈 치료용 피롤 유도체 - Google Patents

에이즈 치료용 피롤 유도체 Download PDF

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Publication number
KR100549884B1
KR100549884B1 KR1020037000138A KR20037000138A KR100549884B1 KR 100549884 B1 KR100549884 B1 KR 100549884B1 KR 1020037000138 A KR1020037000138 A KR 1020037000138A KR 20037000138 A KR20037000138 A KR 20037000138A KR 100549884 B1 KR100549884 B1 KR 100549884B1
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KR
South Korea
Prior art keywords
methyl
pyridyl
isopropyl
pyrrole
dichlorophenylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020037000138A
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English (en)
Korean (ko)
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KR20030014321A (ko
Inventor
다이모크브라이언윌리엄
존스필립스티븐
메레트존허버트
파라트마틴존
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20030014321A publication Critical patent/KR20030014321A/ko
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Publication of KR100549884B1 publication Critical patent/KR100549884B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020037000138A 2000-07-04 2001-04-30 에이즈 치료용 피롤 유도체 Expired - Fee Related KR100549884B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016453.3 2000-07-04
GBGB0016453.3A GB0016453D0 (en) 2000-07-04 2000-07-04 Pyrrole derivatives
PCT/EP2001/004832 WO2002002524A1 (en) 2000-07-04 2001-04-30 Pyrrole derivatives for treating aids

Publications (2)

Publication Number Publication Date
KR20030014321A KR20030014321A (ko) 2003-02-15
KR100549884B1 true KR100549884B1 (ko) 2006-02-06

Family

ID=9895031

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037000138A Expired - Fee Related KR100549884B1 (ko) 2000-07-04 2001-04-30 에이즈 치료용 피롤 유도체

Country Status (17)

Country Link
US (1) US6737429B2 (enExample)
EP (1) EP1301481A1 (enExample)
JP (1) JP2004502674A (enExample)
KR (1) KR100549884B1 (enExample)
CN (1) CN1440385A (enExample)
AR (1) AR028602A1 (enExample)
AU (2) AU2001263874B2 (enExample)
BR (1) BR0112241A (enExample)
CA (1) CA2412270A1 (enExample)
EC (1) ECSP014109A (enExample)
GB (1) GB0016453D0 (enExample)
GT (1) GT200100111A (enExample)
MX (1) MXPA02012409A (enExample)
PA (1) PA8516201A1 (enExample)
PE (1) PE20020269A1 (enExample)
UY (1) UY26720A1 (enExample)
WO (1) WO2002002524A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1405849A1 (en) * 2002-10-04 2004-04-07 Corning Incorporated Halogenated styrene compounds and low-absorption-loss polymers obtainable therefrom
CA2551602C (en) * 2003-12-26 2013-03-26 Masatoshi Hagiwara Methods for controlling sr protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control sr protein activity
US8048909B2 (en) 2004-09-30 2011-11-01 Takeda Pharmaceutical Company Limited Proton pump inhibitors
TW200628446A (en) * 2004-12-14 2006-08-16 Takeda Pharmaceuticals Co Substituted pyrrole derivative
WO2006072833A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
US7977488B2 (en) 2005-08-30 2011-07-12 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
JP2010505834A (ja) * 2006-10-06 2010-02-25 メルク エンド カムパニー インコーポレーテッド 非ヌクレオシド系逆転写酵素阻害剤
WO2008058287A1 (en) * 2006-11-10 2008-05-15 Syndax Pharmaceuticals, Inc. COMBINATION OF ERα+ LIGANDS AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
WO2009015180A2 (en) * 2007-07-23 2009-01-29 Syndax Pharmaceuticals, Inc. Novel compounds and methods of using them
SG185313A1 (en) * 2007-10-16 2012-11-29 Nikon Corp Illumination optical system, exposure apparatus, and device manufacturing method
US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
KR101629181B1 (ko) 2008-08-27 2016-06-13 다케다 야쿠힌 고교 가부시키가이샤 피롤 화합물
GB0823001D0 (en) * 2008-12-17 2009-01-28 Syngenta Participations Ag Thiophene,furan and pyrrole derivatives with plant growth regulating properties
CN101775011B (zh) * 2009-01-13 2013-07-31 中国人民解放军军事医学科学院毒物药物研究所 N-取代苯基-3-甲烯杂环芳烃-2,5-二甲基吡咯类化合物及其抗hiv/aids的应用
CN114727987A (zh) * 2019-11-19 2022-07-08 纽约血库公司 具有hiv治疗活性的经取代杂环化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644631A (en) * 1969-05-13 1972-02-22 Endo Lab Therapeutic methods utilizing aryl pyrrol-3-yl ketones
US4282242A (en) * 1980-03-07 1981-08-04 Pfizer Inc. Antidiabetic pyrrolecarboxylic acids
US4347186A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
BR9307664A (pt) * 1992-12-17 1999-06-29 Pfizer Pirazóis substituídos como antagonistas
CA2192208C (en) * 1994-06-06 2002-09-10 Pfizer Limited Substituted pyrazoles
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
US6417202B1 (en) * 1996-07-11 2002-07-09 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin-and TNF antagonists
DE19963174A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Substituierte Pyrrol-Mannichbasen

Also Published As

Publication number Publication date
CA2412270A1 (en) 2002-01-10
GT200100111A (es) 2002-03-18
UY26720A1 (es) 2001-11-30
WO2002002524A1 (en) 2002-01-10
AU6387401A (en) 2002-01-14
EP1301481A1 (en) 2003-04-16
GB0016453D0 (en) 2000-08-23
JP2004502674A (ja) 2004-01-29
MXPA02012409A (es) 2003-04-25
US20020032221A1 (en) 2002-03-14
PE20020269A1 (es) 2002-04-08
US6737429B2 (en) 2004-05-18
KR20030014321A (ko) 2003-02-15
CN1440385A (zh) 2003-09-03
BR0112241A (pt) 2003-06-24
ECSP014109A (es) 2002-02-25
PA8516201A1 (es) 2002-07-30
AU2001263874B2 (en) 2006-10-19
AR028602A1 (es) 2003-05-14

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