CA2395129C - Process for producing nanometer particles by fluid bed spray-drying - Google Patents
Process for producing nanometer particles by fluid bed spray-drying Download PDFInfo
- Publication number
- CA2395129C CA2395129C CA002395129A CA2395129A CA2395129C CA 2395129 C CA2395129 C CA 2395129C CA 002395129 A CA002395129 A CA 002395129A CA 2395129 A CA2395129 A CA 2395129A CA 2395129 C CA2395129 C CA 2395129C
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- Prior art keywords
- compound
- particles
- agent
- excipient
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000012530 fluid Substances 0.000 title description 12
- 238000001694 spray drying Methods 0.000 title description 9
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- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 37
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- 239000007921 spray Substances 0.000 claims description 13
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 3
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Classifications
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Manufacturing Of Micro-Capsules (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17257399P | 1999-12-20 | 1999-12-20 | |
| US60/172,573 | 1999-12-20 | ||
| PCT/US2000/034606 WO2001045677A1 (en) | 1999-12-20 | 2000-12-19 | Process for producing nanometer particles by fluid bed spray-drying |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2395129A1 CA2395129A1 (en) | 2001-06-28 |
| CA2395129C true CA2395129C (en) | 2008-12-16 |
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| EP (1) | EP1239844B1 (enExample) |
| JP (3) | JP2003518038A (enExample) |
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| AU (2) | AU778931B2 (enExample) |
| CA (1) | CA2395129C (enExample) |
| DE (1) | DE60020732T2 (enExample) |
| ES (1) | ES2240222T3 (enExample) |
| MX (1) | MXPA02006079A (enExample) |
| WO (2) | WO2001045674A1 (enExample) |
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-
2000
- 2000-12-19 US US10/168,520 patent/US7078057B2/en not_active Expired - Lifetime
- 2000-12-19 AT AT00986607T patent/ATE297196T1/de not_active IP Right Cessation
- 2000-12-19 DE DE60020732T patent/DE60020732T2/de not_active Expired - Lifetime
- 2000-12-19 CA CA002395129A patent/CA2395129C/en not_active Expired - Lifetime
- 2000-12-19 AU AU22814/01A patent/AU778931B2/en not_active Ceased
- 2000-12-19 WO PCT/US2000/034479 patent/WO2001045674A1/en not_active Ceased
- 2000-12-19 AU AU25834/01A patent/AU2583401A/en not_active Abandoned
- 2000-12-19 ES ES00986607T patent/ES2240222T3/es not_active Expired - Lifetime
- 2000-12-19 EP EP00986607A patent/EP1239844B1/en not_active Expired - Lifetime
- 2000-12-19 MX MXPA02006079A patent/MXPA02006079A/es active IP Right Grant
- 2000-12-19 JP JP2001546416A patent/JP2003518038A/ja not_active Withdrawn
- 2000-12-19 WO PCT/US2000/034606 patent/WO2001045677A1/en not_active Ceased
-
2009
- 2009-11-27 JP JP2009270841A patent/JP2010090132A/ja active Pending
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2012
- 2012-01-12 JP JP2012004371A patent/JP2012102135A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1239844A1 (en) | 2002-09-18 |
| JP2012102135A (ja) | 2012-05-31 |
| AU2281401A (en) | 2001-07-03 |
| ES2240222T3 (es) | 2005-10-16 |
| EP1239844B1 (en) | 2005-06-08 |
| MXPA02006079A (es) | 2004-08-23 |
| AU778931B2 (en) | 2004-12-23 |
| CA2395129A1 (en) | 2001-06-28 |
| WO2001045677A1 (en) | 2001-06-28 |
| DE60020732D1 (de) | 2005-07-14 |
| JP2010090132A (ja) | 2010-04-22 |
| WO2001045674A1 (en) | 2001-06-28 |
| US7078057B2 (en) | 2006-07-18 |
| JP2003518038A (ja) | 2003-06-03 |
| US20030211162A1 (en) | 2003-11-13 |
| DE60020732T2 (de) | 2006-05-11 |
| AU2583401A (en) | 2001-07-03 |
| ATE297196T1 (de) | 2005-06-15 |
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