CA2383146C - Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique - Google Patents
Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique Download PDFInfo
- Publication number
- CA2383146C CA2383146C CA2383146A CA2383146A CA2383146C CA 2383146 C CA2383146 C CA 2383146C CA 2383146 A CA2383146 A CA 2383146A CA 2383146 A CA2383146 A CA 2383146A CA 2383146 C CA2383146 C CA 2383146C
- Authority
- CA
- Canada
- Prior art keywords
- group
- neuropathic pain
- carbon atoms
- pain
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cette invention concerne des remèdes contre les douleurs neuropathiques dont les composés de principe actif sont représentés par la formule générale (I) (dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, A et B sont tels que définis dans le descriptif) ou sont des sels de ces composés acceptables au plan pharmacologique. L'invention porte également sur des modèles animaux préparés par l'administration de (+)-4a-(3-hydroxyphényle)-2-méthyle-1,2,3,4,4a,5,12,12a-octahydro-trans-quinolino[2,3-g]lisoquinoline. Ces remèdes et ces animaux modèles rendent possible le traitement médicamenteux des douleurs neuropathiques et permettent de surcroît d'évaluer les effets thérapeutiques desdits composés sur les douleurs neuropathiques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11/236778 | 1999-08-24 | ||
JP23677899 | 1999-08-24 | ||
PCT/JP2000/005690 WO2001014383A1 (fr) | 1999-08-24 | 2000-08-24 | Remedes contre les douleurs neuropathiques et modeles animaux de douleurs neuropathiques |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2383146A1 CA2383146A1 (fr) | 2001-03-01 |
CA2383146C true CA2383146C (fr) | 2010-11-16 |
Family
ID=17005666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2383146A Expired - Lifetime CA2383146C (fr) | 1999-08-24 | 2000-08-24 | Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique |
Country Status (8)
Country | Link |
---|---|
US (1) | US8637539B2 (fr) |
EP (1) | EP1219624B1 (fr) |
JP (1) | JP4867123B2 (fr) |
CN (1) | CN1204139C (fr) |
CA (1) | CA2383146C (fr) |
DE (1) | DE60039444D1 (fr) |
ES (1) | ES2308990T3 (fr) |
WO (1) | WO2001014383A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2632544T3 (es) * | 2001-06-07 | 2017-09-14 | Analgesic Neuropharmaceuticals, Llc | Tratamiento de dolor neuropático con el antagonista del receptor de N-metil-D-aspartato (NMDA) dextrometorfano |
JP4957489B2 (ja) * | 2002-10-09 | 2012-06-20 | 東レ株式会社 | 含窒素環状置換基を有するモルヒナン誘導体またはその薬理学的に許容される酸付加塩を含有する医薬 |
CA2521000A1 (fr) * | 2003-04-03 | 2004-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Agent therapeutique et/ou curatif pour les douleurs nevropathiques |
KR101324539B1 (ko) * | 2005-03-10 | 2013-11-01 | 도레이 카부시키가이샤 | 다발성 경화증에 따른 가려움의 치료에 사용하는 제품 |
PL2151240T3 (pl) | 2007-04-24 | 2014-01-31 | Toray Industries | Środek terapeutyczny lub profilaktyczny przeciw dyskinezie |
AU2008268202B2 (en) | 2007-06-22 | 2012-12-20 | Toray Industries, Inc. | Remedy or preventive for integration dysfunction syndrome |
CA2702032C (fr) | 2007-10-05 | 2013-04-02 | Shinji Ona | Agent therapeutique ameliorant les proprietes de la peau comprenant un derive du morphinane ou un de ses sels d'addition acides pharmacologiquement acceptables en tant qu'ingredient actif |
JP5867081B2 (ja) | 2010-01-29 | 2016-02-24 | 東レ株式会社 | 胆道疾患の治療又は予防剤 |
WO2012054566A2 (fr) * | 2010-10-19 | 2012-04-26 | Memorial Sloan-Kettering Cancer Center | Dérivés 6-amido de 4,5a-époxymorphinanes pour traiter une douleur |
CN103327977B (zh) | 2011-01-31 | 2016-05-04 | 东丽株式会社 | 恶液质的治疗或预防剂 |
EP2966074B1 (fr) * | 2013-03-08 | 2018-07-25 | The Kitasato Institute | Dérivé de morphinane |
WO2016176657A1 (fr) | 2015-04-30 | 2016-11-03 | Memorial Sloan-Kettering Cancer Center | Analogues de la mitragynine et leurs utilisations |
EP3761982B1 (fr) | 2018-03-08 | 2024-10-09 | Victoria Link Ltd | Utilisation de la nalfurafine pour le traitement de maladies démyélinisantes |
CN109662802A (zh) * | 2018-12-26 | 2019-04-23 | 南京大学 | 一种检测疼痛评价过程中运动协调性能的方法以及应用 |
US11214577B2 (en) | 2019-03-29 | 2022-01-04 | Humanwell Pharmaceutical US | Morphinans useful for treating medical disorders |
JP2024522192A (ja) | 2021-06-14 | 2024-06-11 | スコーピオン セラピューティクス インコーポレイテッド | がんを処置するために使用され得る尿素誘導体 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0846694A1 (fr) * | 1992-01-23 | 1998-06-10 | Toray Industries, Inc. | Dérivés de morphinane et utilisation en médicine |
US5852030A (en) * | 1992-09-29 | 1998-12-22 | Toray Industries, Inc. | Indole derivatives, process for producing the same and medicinal uses of the same |
ES2199220T3 (es) * | 1992-09-29 | 2004-02-16 | Toray Industries, Inc. | Derivado de indol, procedimiento para su produccion y usos medicinales del mismo. |
AU683664B2 (en) * | 1993-06-30 | 1997-11-20 | Toray Industries, Inc. | Antitussive |
WO1995003307A1 (fr) * | 1993-07-19 | 1995-02-02 | Toray Industries, Inc. | Agent de protection de cellules cerebrales |
WO1995003308A1 (fr) * | 1993-07-23 | 1995-02-02 | Toray Industries, Inc. | Derive de morphinane et application medicale |
KR970706258A (ko) * | 1995-07-20 | 1997-11-03 | 마에다 카쯔노수케 | 4a-아릴데카히드로이소키노린 화합물 및 그 의약 용도(4a-ARYLDECAHYDROISOQUINOLIN COMPOUND AND MEDICINAL USE OF THE SAME) |
JP3123080B2 (ja) * | 1995-09-26 | 2001-01-09 | 東レ株式会社 | 「インドール誘導体およびその医薬用途」 |
DE69732868T2 (de) * | 1996-11-25 | 2006-04-13 | Toray Industries, Inc. | Mittel gegen Juckreiz |
US6440987B1 (en) * | 1996-11-25 | 2002-08-27 | Toray Industries, Inc. | Antipruritic |
JP4110579B2 (ja) * | 1997-01-16 | 2008-07-02 | 東レ株式会社 | インドロモルヒナン誘導体および脳障害治療・予防剤 |
CA2256897C (fr) * | 1997-03-27 | 2006-10-03 | Toray Industries, Inc. | Derives de morphinane et usage medical de ces derniers |
EP0911334B1 (fr) * | 1997-03-31 | 2008-05-21 | Toray Industries, Inc. | Derives de quinolinomorphinane et leur usage medical |
WO2001014382A1 (fr) | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif |
-
2000
- 2000-08-24 JP JP2001518714A patent/JP4867123B2/ja not_active Expired - Lifetime
- 2000-08-24 DE DE60039444T patent/DE60039444D1/de not_active Expired - Lifetime
- 2000-08-24 CN CNB008147833A patent/CN1204139C/zh not_active Expired - Lifetime
- 2000-08-24 ES ES00954975T patent/ES2308990T3/es not_active Expired - Lifetime
- 2000-08-24 WO PCT/JP2000/005690 patent/WO2001014383A1/fr active IP Right Grant
- 2000-08-24 EP EP00954975A patent/EP1219624B1/fr not_active Expired - Lifetime
- 2000-08-24 CA CA2383146A patent/CA2383146C/fr not_active Expired - Lifetime
-
2005
- 2005-08-18 US US11/206,489 patent/US8637539B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1219624A1 (fr) | 2002-07-03 |
EP1219624A4 (fr) | 2004-06-16 |
WO2001014383A1 (fr) | 2001-03-01 |
ES2308990T3 (es) | 2008-12-16 |
CA2383146A1 (fr) | 2001-03-01 |
CN1382145A (zh) | 2002-11-27 |
US8637539B2 (en) | 2014-01-28 |
DE60039444D1 (de) | 2008-08-21 |
US20060094741A1 (en) | 2006-05-04 |
EP1219624B1 (fr) | 2008-07-09 |
CN1204139C (zh) | 2005-06-01 |
JP4867123B2 (ja) | 2012-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20200824 |