CA2383146C - Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique - Google Patents

Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique Download PDF

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Publication number
CA2383146C
CA2383146C CA2383146A CA2383146A CA2383146C CA 2383146 C CA2383146 C CA 2383146C CA 2383146 A CA2383146 A CA 2383146A CA 2383146 A CA2383146 A CA 2383146A CA 2383146 C CA2383146 C CA 2383146C
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CA
Canada
Prior art keywords
group
neuropathic pain
carbon atoms
pain
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2383146A
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English (en)
Other versions
CA2383146A1 (fr
Inventor
Hiroshi Nagase
Takashi Endo
Kuniaki Kawamura
Toshiaki Tanaka
Tomohiko Suzuki
Tsutomu Suzuki
Yasushi Kuraishi
Kimiyasu Shiraki
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Toray Industries Inc
Original Assignee
Toray Industries Inc
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Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of CA2383146A1 publication Critical patent/CA2383146A1/fr
Application granted granted Critical
Publication of CA2383146C publication Critical patent/CA2383146C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne des remèdes contre les douleurs neuropathiques dont les composés de principe actif sont représentés par la formule générale (I) (dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, A et B sont tels que définis dans le descriptif) ou sont des sels de ces composés acceptables au plan pharmacologique. L'invention porte également sur des modèles animaux préparés par l'administration de (+)-4a-(3-hydroxyphényle)-2-méthyle-1,2,3,4,4a,5,12,12a-octahydro-trans-quinolino[2,3-g]lisoquinoline. Ces remèdes et ces animaux modèles rendent possible le traitement médicamenteux des douleurs neuropathiques et permettent de surcroît d'évaluer les effets thérapeutiques desdits composés sur les douleurs neuropathiques.
CA2383146A 1999-08-24 2000-08-24 Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique Expired - Lifetime CA2383146C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11/236778 1999-08-24
JP23677899 1999-08-24
PCT/JP2000/005690 WO2001014383A1 (fr) 1999-08-24 2000-08-24 Remedes contre les douleurs neuropathiques et modeles animaux de douleurs neuropathiques

Publications (2)

Publication Number Publication Date
CA2383146A1 CA2383146A1 (fr) 2001-03-01
CA2383146C true CA2383146C (fr) 2010-11-16

Family

ID=17005666

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2383146A Expired - Lifetime CA2383146C (fr) 1999-08-24 2000-08-24 Agent therapeutique contre la douleur neuropathique et modele animal de douleur neuropathique

Country Status (8)

Country Link
US (1) US8637539B2 (fr)
EP (1) EP1219624B1 (fr)
JP (1) JP4867123B2 (fr)
CN (1) CN1204139C (fr)
CA (1) CA2383146C (fr)
DE (1) DE60039444D1 (fr)
ES (1) ES2308990T3 (fr)
WO (1) WO2001014383A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2632544T3 (es) * 2001-06-07 2017-09-14 Analgesic Neuropharmaceuticals, Llc Tratamiento de dolor neuropático con el antagonista del receptor de N-metil-D-aspartato (NMDA) dextrometorfano
JP4957489B2 (ja) * 2002-10-09 2012-06-20 東レ株式会社 含窒素環状置換基を有するモルヒナン誘導体またはその薬理学的に許容される酸付加塩を含有する医薬
CA2521000A1 (fr) * 2003-04-03 2004-10-21 Kyowa Hakko Kogyo Co., Ltd. Agent therapeutique et/ou curatif pour les douleurs nevropathiques
KR101324539B1 (ko) * 2005-03-10 2013-11-01 도레이 카부시키가이샤 다발성 경화증에 따른 가려움의 치료에 사용하는 제품
PL2151240T3 (pl) 2007-04-24 2014-01-31 Toray Industries Środek terapeutyczny lub profilaktyczny przeciw dyskinezie
AU2008268202B2 (en) 2007-06-22 2012-12-20 Toray Industries, Inc. Remedy or preventive for integration dysfunction syndrome
CA2702032C (fr) 2007-10-05 2013-04-02 Shinji Ona Agent therapeutique ameliorant les proprietes de la peau comprenant un derive du morphinane ou un de ses sels d'addition acides pharmacologiquement acceptables en tant qu'ingredient actif
JP5867081B2 (ja) 2010-01-29 2016-02-24 東レ株式会社 胆道疾患の治療又は予防剤
WO2012054566A2 (fr) * 2010-10-19 2012-04-26 Memorial Sloan-Kettering Cancer Center Dérivés 6-amido de 4,5a-époxymorphinanes pour traiter une douleur
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
EP2966074B1 (fr) * 2013-03-08 2018-07-25 The Kitasato Institute Dérivé de morphinane
WO2016176657A1 (fr) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Analogues de la mitragynine et leurs utilisations
EP3761982B1 (fr) 2018-03-08 2024-10-09 Victoria Link Ltd Utilisation de la nalfurafine pour le traitement de maladies démyélinisantes
CN109662802A (zh) * 2018-12-26 2019-04-23 南京大学 一种检测疼痛评价过程中运动协调性能的方法以及应用
US11214577B2 (en) 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders
JP2024522192A (ja) 2021-06-14 2024-06-11 スコーピオン セラピューティクス インコーポレイテッド がんを処置するために使用され得る尿素誘導体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0846694A1 (fr) * 1992-01-23 1998-06-10 Toray Industries, Inc. Dérivés de morphinane et utilisation en médicine
US5852030A (en) * 1992-09-29 1998-12-22 Toray Industries, Inc. Indole derivatives, process for producing the same and medicinal uses of the same
ES2199220T3 (es) * 1992-09-29 2004-02-16 Toray Industries, Inc. Derivado de indol, procedimiento para su produccion y usos medicinales del mismo.
AU683664B2 (en) * 1993-06-30 1997-11-20 Toray Industries, Inc. Antitussive
WO1995003307A1 (fr) * 1993-07-19 1995-02-02 Toray Industries, Inc. Agent de protection de cellules cerebrales
WO1995003308A1 (fr) * 1993-07-23 1995-02-02 Toray Industries, Inc. Derive de morphinane et application medicale
KR970706258A (ko) * 1995-07-20 1997-11-03 마에다 카쯔노수케 4a-아릴데카히드로이소키노린 화합물 및 그 의약 용도(4a-ARYLDECAHYDROISOQUINOLIN COMPOUND AND MEDICINAL USE OF THE SAME)
JP3123080B2 (ja) * 1995-09-26 2001-01-09 東レ株式会社 「インドール誘導体およびその医薬用途」
DE69732868T2 (de) * 1996-11-25 2006-04-13 Toray Industries, Inc. Mittel gegen Juckreiz
US6440987B1 (en) * 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
JP4110579B2 (ja) * 1997-01-16 2008-07-02 東レ株式会社 インドロモルヒナン誘導体および脳障害治療・予防剤
CA2256897C (fr) * 1997-03-27 2006-10-03 Toray Industries, Inc. Derives de morphinane et usage medical de ces derniers
EP0911334B1 (fr) * 1997-03-31 2008-05-21 Toray Industries, Inc. Derives de quinolinomorphinane et leur usage medical
WO2001014382A1 (fr) 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif

Also Published As

Publication number Publication date
EP1219624A1 (fr) 2002-07-03
EP1219624A4 (fr) 2004-06-16
WO2001014383A1 (fr) 2001-03-01
ES2308990T3 (es) 2008-12-16
CA2383146A1 (fr) 2001-03-01
CN1382145A (zh) 2002-11-27
US8637539B2 (en) 2014-01-28
DE60039444D1 (de) 2008-08-21
US20060094741A1 (en) 2006-05-04
EP1219624B1 (fr) 2008-07-09
CN1204139C (zh) 2005-06-01
JP4867123B2 (ja) 2012-02-01

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Effective date: 20200824