CA2381882C - Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases - Google Patents

Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases Download PDF

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Publication number
CA2381882C
CA2381882C CA2381882A CA2381882A CA2381882C CA 2381882 C CA2381882 C CA 2381882C CA 2381882 A CA2381882 A CA 2381882A CA 2381882 A CA2381882 A CA 2381882A CA 2381882 C CA2381882 C CA 2381882C
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Canada
Prior art keywords
substituted
disease
phenyl
aryl
heterocyclyl
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Expired - Fee Related
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CA2381882A
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English (en)
French (fr)
Other versions
CA2381882A1 (en
Inventor
Jeremy Green
Guy Bemis
Anne-Laure Grillot
Mark Ledeboer
Francis Salituro
Edmund Harrington
Huai Gao
Christopher Baker
Jingrong Cao
Michael Hale
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CA2381882A1 publication Critical patent/CA2381882A1/en
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Publication of CA2381882C publication Critical patent/CA2381882C/en
Anticipated expiration legal-status Critical
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
CA2381882A 1999-08-13 2000-08-11 Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases Expired - Fee Related CA2381882C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US60/148,795 1999-08-12
US14879599P 1999-08-13 1999-08-13
US16692299P 1999-11-22 1999-11-22
US60/166,922 1999-11-22
US21151700P 2000-06-14 2000-06-14
US60/211,517 2000-06-14
PCT/US2000/022445 WO2001012621A1 (en) 1999-08-13 2000-08-11 INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES

Publications (2)

Publication Number Publication Date
CA2381882A1 CA2381882A1 (en) 2001-02-22
CA2381882C true CA2381882C (en) 2011-01-25

Family

ID=27386739

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2381882A Expired - Fee Related CA2381882C (en) 1999-08-13 2000-08-11 Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases

Country Status (22)

Country Link
US (2) US6693108B2 (https=)
EP (1) EP1218369B1 (https=)
JP (1) JP2003531103A (https=)
KR (1) KR20020030791A (https=)
CN (1) CN1222520C (https=)
AR (1) AR032130A1 (https=)
AT (1) ATE402163T1 (https=)
AU (1) AU6909600A (https=)
BR (1) BR0013551A (https=)
CA (1) CA2381882C (https=)
CO (1) CO5200770A1 (https=)
CZ (1) CZ2002534A3 (https=)
DE (1) DE60039616D1 (https=)
HK (1) HK1045507A1 (https=)
HU (1) HUP0300340A3 (https=)
MX (1) MXPA02001565A (https=)
MY (1) MY133159A (https=)
NO (1) NO20020713L (https=)
NZ (1) NZ517694A (https=)
PL (1) PL366110A1 (https=)
SK (1) SK3572002A3 (https=)
WO (1) WO2001012621A1 (https=)

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US20040072888A1 (en) 1999-08-19 2004-04-15 Bennett Brydon L. Methods for treating inflammatory conditions or inhibiting JNK
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US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
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US7473691B2 (en) 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
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