HK1045507A1 - C-jun n-末端激酶(jnk)及其他蛋白质激酶的抑制物 - Google Patents

C-jun n-末端激酶(jnk)及其他蛋白质激酶的抑制物 Download PDF

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Publication number
HK1045507A1
HK1045507A1 HK02106918.4A HK02106918A HK1045507A1 HK 1045507 A1 HK1045507 A1 HK 1045507A1 HK 02106918 A HK02106918 A HK 02106918A HK 1045507 A1 HK1045507 A1 HK 1045507A1
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HK
Hong Kong
Prior art keywords
inhibitors
sub
sup
kinases
jnk
Prior art date
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HK02106918.4A
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English (en)
Chinese (zh)
Inventor
Green Jeremy
Bemis Guy
Grillot Anne-Laure
Ledeboer Mark
Salituro Francis
Harrington Edmund
Gao Huai
Baker Christopher
Cao Jingrong
Hale Michael
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Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of HK1045507A1 publication Critical patent/HK1045507A1/zh

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
HK02106918.4A 1999-08-12 2000-08-11 C-jun n-末端激酶(jnk)及其他蛋白质激酶的抑制物 HK1045507A1 (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US148795P 1999-08-12
US14879599P 1999-08-13 1999-08-13
US16692299P 1999-11-22 1999-11-22
US166922P 1999-11-22
US21151700P 2000-06-14 2000-06-14
US211517P 2000-06-14
PCT/US2000/022445 WO2001012621A1 (en) 1999-08-13 2000-08-11 INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES

Publications (1)

Publication Number Publication Date
HK1045507A1 true HK1045507A1 (zh) 2002-11-29

Family

ID=27386739

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106918.4A HK1045507A1 (zh) 1999-08-12 2000-08-11 C-jun n-末端激酶(jnk)及其他蛋白质激酶的抑制物

Country Status (22)

Country Link
US (2) US6693108B2 (https=)
EP (1) EP1218369B1 (https=)
JP (1) JP2003531103A (https=)
KR (1) KR20020030791A (https=)
CN (1) CN1222520C (https=)
AR (1) AR032130A1 (https=)
AT (1) ATE402163T1 (https=)
AU (1) AU6909600A (https=)
BR (1) BR0013551A (https=)
CA (1) CA2381882C (https=)
CO (1) CO5200770A1 (https=)
CZ (1) CZ2002534A3 (https=)
DE (1) DE60039616D1 (https=)
HK (1) HK1045507A1 (https=)
HU (1) HUP0300340A3 (https=)
MX (1) MXPA02001565A (https=)
MY (1) MY133159A (https=)
NO (1) NO20020713L (https=)
NZ (1) NZ517694A (https=)
PL (1) PL366110A1 (https=)
SK (1) SK3572002A3 (https=)
WO (1) WO2001012621A1 (https=)

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US20040072888A1 (en) 1999-08-19 2004-04-15 Bennett Brydon L. Methods for treating inflammatory conditions or inhibiting JNK
US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
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US7429599B2 (en) 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
US6989385B2 (en) 2000-12-21 2006-01-24 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
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JP4414219B2 (ja) 2001-07-23 2010-02-10 メルク セローノ ソシエテ アノニム Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）インヒビターとしてのアリールスルホンアミド誘導体
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JP2005518371A (ja) 2001-12-10 2005-06-23 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療に於けるこれらの使用
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