CA2373077A1 - Sels d'intermediaires de 2,2-dimethyl-1,3-dioxane et leur procede de preparation - Google Patents

Sels d'intermediaires de 2,2-dimethyl-1,3-dioxane et leur procede de preparation Download PDF

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Publication number
CA2373077A1
CA2373077A1 CA002373077A CA2373077A CA2373077A1 CA 2373077 A1 CA2373077 A1 CA 2373077A1 CA 002373077 A CA002373077 A CA 002373077A CA 2373077 A CA2373077 A CA 2373077A CA 2373077 A1 CA2373077 A1 CA 2373077A1
Authority
CA
Canada
Prior art keywords
acid
dimethyl
carboxylic acid
formula
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002373077A
Other languages
English (en)
Inventor
Jozsef Barkoczy
Laszlo Balazs
Gyula Simig
Peter Seres
Zoltan Greff
Zoltan Ratkai
Ferenc Bartha
Gyorgyi Vereczkeyne Donath
Peter Kotay Nagy
Kalman Nagy
Imre Doman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2373077A1 publication Critical patent/CA2373077A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Abstract

L'invention concerne des sels de (4R-cis) -(1,1-diméthyl -éthyl) -6-(2-aminoéthyl) -2,2-diméthyl -1,3-dioxane -4-acétate de formule (I), ces sels étant formés avec des acides organiques. Les nouveaux sels de cette invention sont stables et aptes à être facilement purifiés par recristallisation. Les nouveaux sels de cette invention constituent par ailleurs de précieux intermédiaires pharmaceutiques pouvant être utilisés par exemple pour préparer un agent hypolipidémique ci-après dénommé atorvastatine (selon la dénomination DCI). Cette invention concerne enfin la préparation de nouveaux sels du composé de formule (I) susmentionné.
CA002373077A 1999-05-06 2000-05-05 Sels d'intermediaires de 2,2-dimethyl-1,3-dioxane et leur procede de preparation Abandoned CA2373077A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP9901526 1999-05-06
HU9901526A HU227840B1 (en) 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them
PCT/HU2000/000042 WO2000068221A1 (fr) 1999-05-06 2000-05-05 Sels d'intermediaires de 2,2-dimethyl-1,3-dioxane et leur procede de preparation

Publications (1)

Publication Number Publication Date
CA2373077A1 true CA2373077A1 (fr) 2000-11-16

Family

ID=89998261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002373077A Abandoned CA2373077A1 (fr) 1999-05-06 2000-05-05 Sels d'intermediaires de 2,2-dimethyl-1,3-dioxane et leur procede de preparation

Country Status (14)

Country Link
EP (1) EP1178980A1 (fr)
JP (1) JP2002544207A (fr)
KR (1) KR20020033617A (fr)
CN (1) CN1349522A (fr)
AU (1) AU4600200A (fr)
CA (1) CA2373077A1 (fr)
CZ (1) CZ20013965A3 (fr)
HK (1) HK1046271A1 (fr)
HR (1) HRP20010846A2 (fr)
HU (1) HU227840B1 (fr)
PL (1) PL351145A1 (fr)
RU (1) RU2001133066A (fr)
SK (1) SK15842001A3 (fr)
WO (1) WO2000068221A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108191813A (zh) * 2017-12-20 2018-06-22 帕潘纳(北京)科技有限公司 一种缩酮的制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
WO2002057229A1 (fr) * 2001-01-19 2002-07-25 Biocon India Limited FORME V CRISTALLINE DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE)
CA2451159A1 (fr) 2001-07-06 2003-01-16 Teva Pharmaceutical Industries Ltd. Procede de preparation de derives d'acide 7-amino syn 3,5-dihydroxy heptanoique via des derives d'acide 6-cyano syn 3,5-dihydroxy hexanoique
EP1323717A1 (fr) 2001-12-27 2003-07-02 Dsm N.V. Procédé de Préparation de Dérivés de l'acide 2-(1,3-dioxane-4-yl substitué en 6) acétique
EP1375493A1 (fr) * 2002-06-17 2004-01-02 Dsm N.V. Procédé de fabrication d'un ester d'acide acétique de dioxane
ATE509009T1 (de) 2005-03-14 2011-05-15 C P Pharmaceuticals Internat C V Herstellung eines atorvastatin-zwischenprodukts unter anwendung einer paal-knorr-kondensation
WO2007034909A1 (fr) * 2005-09-22 2007-03-29 Kaneka Corporation Procédé pour la production d'un dérivé de l'acide (3r,5r)-7-amino-3,5-dihydroxyheptanoïque
WO2012032035A1 (fr) 2010-09-09 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Sels d'esters d'acides 7-amino-3,5-dihydroxyheptanoïques
WO2017022846A1 (fr) 2015-08-05 2017-02-09 株式会社エーピーアイ コーポレーション Procédé de production de pitavastatine calcique
CN109232353A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种阿托伐他汀钙缩合物的制备方法
CN109232354A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种高纯度阿托伐他汀钙原料药的制备方法
CN110940764B (zh) * 2019-12-31 2022-06-28 湖南九典制药股份有限公司 一种他汀类药物光学异构体的分离方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3652394B2 (ja) * 1995-01-27 2005-05-25 高砂香料工業株式会社 Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
CN1093126C (zh) * 1996-07-29 2002-10-23 沃尼尔·朗伯公司 合成被保护的(s)－3,4－二羟基丁酸酯的改进方法
HUP0103659A3 (en) * 1998-04-30 2003-01-28 Kaneka Corp Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108191813A (zh) * 2017-12-20 2018-06-22 帕潘纳(北京)科技有限公司 一种缩酮的制备方法

Also Published As

Publication number Publication date
WO2000068221A1 (fr) 2000-11-16
SK15842001A3 (sk) 2002-04-04
JP2002544207A (ja) 2002-12-24
CZ20013965A3 (cs) 2002-04-17
HK1046271A1 (zh) 2003-01-03
HRP20010846A2 (en) 2003-02-28
PL351145A1 (en) 2003-03-24
HU9901526D0 (en) 1999-07-28
HU227840B1 (en) 2012-05-02
EP1178980A1 (fr) 2002-02-13
RU2001133066A (ru) 2004-02-27
HUP9901526A2 (hu) 2001-04-28
AU4600200A (en) 2000-11-21
KR20020033617A (ko) 2002-05-07
CN1349522A (zh) 2002-05-15

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Legal Events

Date Code Title Description
FZDE Discontinued