CA2362560A1 - Controlling protein levels in eucaryotic organisms - Google Patents
Controlling protein levels in eucaryotic organisms Download PDFInfo
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- CA2362560A1 CA2362560A1 CA002362560A CA2362560A CA2362560A1 CA 2362560 A1 CA2362560 A1 CA 2362560A1 CA 002362560 A CA002362560 A CA 002362560A CA 2362560 A CA2362560 A CA 2362560A CA 2362560 A1 CA2362560 A1 CA 2362560A1
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- Prior art keywords
- ubiquitination
- target protein
- epsilon
- ahx
- compound
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Classifications
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11985199P | 1999-02-12 | 1999-02-12 | |
| US09/406,781 US6306663B1 (en) | 1999-02-12 | 1999-09-28 | Controlling protein levels in eucaryotic organisms |
| US09/406,781 | 1999-09-28 | ||
| US60/119,851 | 1999-09-28 | ||
| PCT/US2000/003436 WO2000047220A1 (en) | 1999-02-12 | 2000-02-11 | Controlling protein levels in eucaryotic organisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2362560A1 true CA2362560A1 (en) | 2000-08-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002362560A Abandoned CA2362560A1 (en) | 1999-02-12 | 2000-02-11 | Controlling protein levels in eucaryotic organisms |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6306663B1 (https=) |
| EP (1) | EP1156817B1 (https=) |
| JP (1) | JP2002536417A (https=) |
| AT (1) | ATE406170T1 (https=) |
| AU (1) | AU2989300A (https=) |
| CA (1) | CA2362560A1 (https=) |
| DE (1) | DE60040060D1 (https=) |
| WO (1) | WO2000047220A1 (https=) |
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| AU1113999A (en) * | 1997-10-21 | 1999-05-10 | Regents Of The University Of California, The | Target sequences for synthetic molecules and methods of using same |
| US6436392B1 (en) | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
| US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| JP4969002B2 (ja) * | 1999-06-08 | 2012-07-04 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | ｒＡＡＶ形質導入を増加するための化合物および方法 |
| US7122335B1 (en) | 1999-06-08 | 2006-10-17 | University Of Iowa Research Foundation | Compounds and methods to enhance rAAV transduction |
| US6979551B2 (en) * | 2000-04-03 | 2005-12-27 | Rigel Pharmaceuticals, Inc. | Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents |
| US6740495B1 (en) * | 2000-04-03 | 2004-05-25 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase assay |
| US7208157B2 (en) * | 2000-09-08 | 2007-04-24 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| US7041298B2 (en) | 2000-09-08 | 2006-05-09 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| US8241622B2 (en) | 2001-07-13 | 2012-08-14 | University Of Iowa Research Foundation | Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences |
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| US7223556B1 (en) * | 1998-10-09 | 2007-05-29 | President And Fellows Of Harvard College | Targeted proteolysis by recruitment to ubiquitin protein ligases |
| US6306663B1 (en) * | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| WO2000075184A1 (en) * | 1999-06-04 | 2000-12-14 | Yale University | Modulation of protein levels using the scf complex |
| US7041298B2 (en) * | 2000-09-08 | 2006-05-09 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
-
1999
- 1999-09-28 US US09/406,781 patent/US6306663B1/en not_active Expired - Fee Related
-
2000
- 2000-02-11 CA CA002362560A patent/CA2362560A1/en not_active Abandoned
- 2000-02-11 EP EP00908580A patent/EP1156817B1/en not_active Expired - Lifetime
- 2000-02-11 WO PCT/US2000/003436 patent/WO2000047220A1/en not_active Ceased
- 2000-02-11 JP JP2000598172A patent/JP2002536417A/ja active Pending
- 2000-02-11 AU AU29893/00A patent/AU2989300A/en not_active Abandoned
- 2000-02-11 DE DE60040060T patent/DE60040060D1/de not_active Expired - Fee Related
- 2000-02-11 AT AT00908580T patent/ATE406170T1/de not_active IP Right Cessation
-
2001
- 2001-06-14 US US09/880,132 patent/US6559280B2/en not_active Expired - Fee Related
- 2001-06-14 US US09/880,149 patent/US7074620B2/en not_active Expired - Fee Related
-
2003
- 2003-01-16 US US10/345,281 patent/US7273920B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030153727A1 (en) | 2003-08-14 |
| US6559280B2 (en) | 2003-05-06 |
| US20020146843A1 (en) | 2002-10-10 |
| EP1156817A4 (en) | 2006-01-11 |
| WO2000047220A1 (en) | 2000-08-17 |
| DE60040060D1 (de) | 2008-10-09 |
| US20020173049A1 (en) | 2002-11-21 |
| EP1156817A1 (en) | 2001-11-28 |
| AU2989300A (en) | 2000-08-29 |
| ATE406170T1 (de) | 2008-09-15 |
| US6306663B1 (en) | 2001-10-23 |
| JP2002536417A (ja) | 2002-10-29 |
| EP1156817B1 (en) | 2008-08-27 |
| US7074620B2 (en) | 2006-07-11 |
| US7273920B2 (en) | 2007-09-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |