CA2338209A1 - Derives de biphenyle - Google Patents
Derives de biphenyle Download PDFInfo
- Publication number
- CA2338209A1 CA2338209A1 CA002338209A CA2338209A CA2338209A1 CA 2338209 A1 CA2338209 A1 CA 2338209A1 CA 002338209 A CA002338209 A CA 002338209A CA 2338209 A CA2338209 A CA 2338209A CA 2338209 A1 CA2338209 A1 CA 2338209A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- formula
- phenyl
- methoxy
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
L'invention concerne des dérivés de biphényle de la formule (I) dans laquelle R, X, Y, A?1¿, A?2¿, A?3¿, Q et n sont comme définis dans la revendication 1; ces dérivés de biphényle et leurs sels sont actifs sur le système nerveux central et possèdent des propriétés antagonistes de la sérotonine.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98113488.5 | 1998-07-20 | ||
EP98113488 | 1998-07-20 | ||
PCT/EP1999/004803 WO2000005225A1 (fr) | 1998-07-20 | 1999-07-08 | Derives de biphenyle |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2338209A1 true CA2338209A1 (fr) | 2000-02-03 |
Family
ID=8232308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002338209A Abandoned CA2338209A1 (fr) | 1998-07-20 | 1999-07-08 | Derives de biphenyle |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1098892A1 (fr) |
JP (1) | JP2002521377A (fr) |
KR (1) | KR20010070997A (fr) |
CN (1) | CN1309654A (fr) |
AR (1) | AR019415A1 (fr) |
AU (1) | AU5033899A (fr) |
BR (1) | BR9912299A (fr) |
CA (1) | CA2338209A1 (fr) |
HU (1) | HUP0102622A3 (fr) |
ID (1) | ID27846A (fr) |
NO (1) | NO20010333L (fr) |
PL (1) | PL345283A1 (fr) |
SK (1) | SK492001A3 (fr) |
WO (1) | WO2000005225A1 (fr) |
ZA (1) | ZA200101379B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002040024A1 (fr) * | 2000-11-14 | 2002-05-23 | Merck Patent Gmbh | Utilisations nouvelles d'agonistes 5-ht1a et d'inhibiteurs de recaptage de serotinine combines |
ATE338544T1 (de) | 2000-12-21 | 2006-09-15 | Nitromed Inc | Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren |
WO2002092585A1 (fr) | 2001-05-11 | 2002-11-21 | Biovitrum Ab | Composes arylsulfonamide pour le traitement de l'obesite, de diabetes de type ii et de troubles du systeme nerveux central |
US7718650B2 (en) | 2001-05-11 | 2010-05-18 | Biovitrum Ab | Aryl sulfonamide compounds for treating obesity |
CN1578663B (zh) | 2001-09-14 | 2011-05-25 | 梅特希尔基因公司 | 组蛋白脱乙酰化酶抑制剂 |
SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
EP1778679A1 (fr) | 2004-07-28 | 2007-05-02 | Glaxo Group Limited | Derives de piperazine convenant pour le traitement de troubles gastro-intestinaux |
ATE504566T1 (de) * | 2004-10-14 | 2011-04-15 | Abbott Gmbh & Co Kg | Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen |
WO2007077457A2 (fr) * | 2006-01-06 | 2007-07-12 | The Royal Veterinary College | Traitement de la fourbure chez le cheval |
PE20080176A1 (es) | 2006-03-31 | 2008-04-25 | Glaxo Group Ltd | Compuestos de arilpiperazina sulfonamida como agonista de los receptores de secretagogos de la hormona de crecimiento (ghs) |
EP2029528A1 (fr) * | 2006-04-19 | 2009-03-04 | Abbott GmbH & Co. KG | Arylsulfones hétérocycliques pouvant être employés pour traiter des troubles qui répondent à la modulation du récepteur de la sérotonine 5ht6 |
WO2007118900A1 (fr) | 2006-04-19 | 2007-10-25 | Abbott Gmbh & Co. Kg | Composés hétérocycliques pouvant être utilisés pour traiter des troubles qui répondent à la modulation du récepteur de sérotonine 5ht6 |
CN101432261A (zh) | 2006-05-19 | 2009-05-13 | 惠氏公司 | 作为组织胺-3拮抗剂的n-苯甲酰基-吡咯烷-3-基胺和n-苄基-吡咯烷-3-基胺 |
KR20090123977A (ko) | 2007-03-23 | 2009-12-02 | 애보트 게엠베하 운트 콤파니 카게 | 세로토닌 5-ht6 수용체의 조절에 반응하는 장애를 치료하는데 적합한 아제티딘 화합물 |
JP5444535B2 (ja) | 2007-06-05 | 2014-03-19 | インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー | 皮質カテコールアミン作動性神経伝達の調節物質としての新規な二置換フェニルピロリジン |
WO2008148851A1 (fr) | 2007-06-08 | 2008-12-11 | Janssen Pharmaceutica N.V. | Dérivés de piperidine/piperazine |
EP2152271B1 (fr) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Dérivés de piperidine/piperazine |
ES2536406T3 (es) | 2007-06-08 | 2015-05-25 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
PE20140572A1 (es) | 2008-06-05 | 2014-05-16 | Janssen Pharmaceutica Nv | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT533268E (pt) * | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
GB2273930A (en) * | 1992-12-30 | 1994-07-06 | Glaxo Group Ltd | Benzanilide derivatives |
GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
-
1999
- 1999-07-08 BR BR9912299-5A patent/BR9912299A/pt not_active Application Discontinuation
- 1999-07-08 KR KR1020017000849A patent/KR20010070997A/ko not_active Application Discontinuation
- 1999-07-08 PL PL99345283A patent/PL345283A1/xx unknown
- 1999-07-08 CN CN99808739A patent/CN1309654A/zh active Pending
- 1999-07-08 EP EP99934632A patent/EP1098892A1/fr not_active Withdrawn
- 1999-07-08 HU HU0102622A patent/HUP0102622A3/hu unknown
- 1999-07-08 SK SK49-2001A patent/SK492001A3/sk unknown
- 1999-07-08 JP JP2000561181A patent/JP2002521377A/ja active Pending
- 1999-07-08 ID IDW20010307A patent/ID27846A/id unknown
- 1999-07-08 AU AU50338/99A patent/AU5033899A/en not_active Abandoned
- 1999-07-08 CA CA002338209A patent/CA2338209A1/fr not_active Abandoned
- 1999-07-08 WO PCT/EP1999/004803 patent/WO2000005225A1/fr not_active Application Discontinuation
- 1999-07-16 AR ARP990103510A patent/AR019415A1/es not_active Application Discontinuation
-
2001
- 2001-01-19 NO NO20010333A patent/NO20010333L/no unknown
- 2001-02-19 ZA ZA200101379A patent/ZA200101379B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR019415A1 (es) | 2002-02-20 |
NO20010333D0 (no) | 2001-01-19 |
HUP0102622A2 (hu) | 2001-12-28 |
AU5033899A (en) | 2000-02-14 |
PL345283A1 (en) | 2001-12-03 |
HUP0102622A3 (en) | 2002-12-28 |
SK492001A3 (en) | 2001-08-06 |
ZA200101379B (en) | 2002-05-20 |
WO2000005225A1 (fr) | 2000-02-03 |
BR9912299A (pt) | 2001-11-20 |
CN1309654A (zh) | 2001-08-22 |
KR20010070997A (ko) | 2001-07-28 |
NO20010333L (no) | 2001-01-19 |
EP1098892A1 (fr) | 2001-05-16 |
JP2002521377A (ja) | 2002-07-16 |
ID27846A (id) | 2001-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |