CA2293404A1 - Procede de preparation de composes de phenyloxyrane actifs sur le plan optique - Google Patents

Procede de preparation de composes de phenyloxyrane actifs sur le plan optique Download PDF

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Publication number
CA2293404A1
CA2293404A1 CA002293404A CA2293404A CA2293404A1 CA 2293404 A1 CA2293404 A1 CA 2293404A1 CA 002293404 A CA002293404 A CA 002293404A CA 2293404 A CA2293404 A CA 2293404A CA 2293404 A1 CA2293404 A1 CA 2293404A1
Authority
CA
Canada
Prior art keywords
group
formula
compound
hydrogen atom
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002293404A
Other languages
English (en)
Inventor
Mari Kusama
Hiroaki Arakawa
Naoyuki Harada
Tooru Kuroda
Tomiki Hashiyama
Yasuhiko Ozaki
Masahiko Seki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2293404A1 publication Critical patent/CA2293404A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention concerne un procédé de préparation d'un composé de phényloxyrane actif sur le plan optique, lequel composé correspond à la formule (II) où l'anneau A représente un anneau de benzène substitué ou non. R représente un groupe -CO¿2?R?q¿ ou un groupe pouvant être transformé en un groupe -CO¿2?R?q¿, étant entendu que R?q¿ représente un résidu d'ester. Le symbole * représente enfin un atome de carbone asymétrique. Ce procédé fait appel à un dérivé de styrène correspondant à la formule (I) où l'anneau A et R sont tels que définis précédemment. Ce procédé consiste à traiter le dérivé de styrène à l'aide d'un agent d'oxydation asymétrique qui se compose d'un composé de cétone chiral et d'un agent oxydant ou, encore, d'un composé de dioxyrane chiral.
CA002293404A 1997-06-11 1998-06-05 Procede de preparation de composes de phenyloxyrane actifs sur le plan optique Abandoned CA2293404A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP9/171042 1997-06-11
JP17104297 1997-06-11
JP35554697 1997-12-24
JP9/355546 1997-12-24
PCT/JP1998/002521 WO1998056762A2 (fr) 1997-06-11 1998-06-05 Procede de preparation de composes de phenyloxyrane actifs sur le plan optique

Publications (1)

Publication Number Publication Date
CA2293404A1 true CA2293404A1 (fr) 1998-12-17

Family

ID=26493875

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293404A Abandoned CA2293404A1 (fr) 1997-06-11 1998-06-05 Procede de preparation de composes de phenyloxyrane actifs sur le plan optique

Country Status (7)

Country Link
EP (1) EP0988297A2 (fr)
KR (1) KR20010013668A (fr)
CN (1) CN1266430A (fr)
AU (1) AU7551998A (fr)
CA (1) CA2293404A1 (fr)
IL (1) IL133095A0 (fr)
WO (1) WO1998056762A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046257A1 (fr) * 1998-03-11 1999-09-16 Tanabe Seiyaku Co., Ltd. Production de biaryldicarboxylate d'oxoalkylene
AU2960099A (en) * 1998-04-08 1999-11-01 Tanabe Seiyaku Co., Ltd. Process for producing hydroxylactone compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552695A (en) * 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
JPS59196881A (ja) * 1983-04-21 1984-11-08 Shionogi & Co Ltd 新規なエポキシド誘導体
JPS6013776A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸誘導体の製造法
US4885375A (en) * 1988-05-18 1989-12-05 Marion Laboratories, Inc. Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
FI95931C (fi) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi
JPH0678B2 (ja) * 1988-09-02 1994-01-05 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
IT1249777B (it) * 1990-05-17 1995-03-18 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.
JP2622251B2 (ja) * 1992-09-03 1997-06-18 田辺製薬株式会社 光学活性３−（４−メトキシフェニル）グリシッド酸エステル類化合物の製法
ZA94284B (en) * 1993-01-27 1994-08-17 Shionogi & Co Process for preparing benzothiazepine derivatives

Also Published As

Publication number Publication date
CN1266430A (zh) 2000-09-13
EP0988297A2 (fr) 2000-03-29
WO1998056762A2 (fr) 1998-12-17
IL133095A0 (en) 2001-03-19
AU7551998A (en) 1998-12-30
WO1998056762A3 (fr) 1999-03-25
KR20010013668A (ko) 2001-02-26

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Legal Events

Date Code Title Description
FZDE Discontinued