CA2274202A1 - Diaza-spiro[3,5]nonane derivatives - Google Patents

Diaza-spiro[3,5]nonane derivatives Download PDF

Info

Publication number
CA2274202A1
CA2274202A1 CA002274202A CA2274202A CA2274202A1 CA 2274202 A1 CA2274202 A1 CA 2274202A1 CA 002274202 A CA002274202 A CA 002274202A CA 2274202 A CA2274202 A CA 2274202A CA 2274202 A1 CA2274202 A1 CA 2274202A1
Authority
CA
Canada
Prior art keywords
phenyl
diaza
spiro
nonan
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002274202A
Other languages
English (en)
French (fr)
Inventor
Geo Adam
Andrea Cesura
Francois Jenck
Sabine Kolczewski
Stephan Rover
Jurgen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2274202A1 publication Critical patent/CA2274202A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
CA002274202A 1998-06-12 1999-06-09 Diaza-spiro[3,5]nonane derivatives Abandoned CA2274202A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12
EP98110804.6 1998-06-12

Publications (1)

Publication Number Publication Date
CA2274202A1 true CA2274202A1 (en) 1999-12-12

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274202A Abandoned CA2274202A1 (en) 1998-06-12 1999-06-09 Diaza-spiro[3,5]nonane derivatives

Country Status (28)

Country Link
US (1) US6113527A (cg-RX-API-DMAC7.html)
EP (1) EP0970957B1 (cg-RX-API-DMAC7.html)
JP (1) JP3286268B2 (cg-RX-API-DMAC7.html)
KR (1) KR100344732B1 (cg-RX-API-DMAC7.html)
CN (1) CN1107066C (cg-RX-API-DMAC7.html)
AR (1) AR019859A1 (cg-RX-API-DMAC7.html)
AT (1) ATE204279T1 (cg-RX-API-DMAC7.html)
AU (1) AU743983B2 (cg-RX-API-DMAC7.html)
BR (1) BR9902651A (cg-RX-API-DMAC7.html)
CA (1) CA2274202A1 (cg-RX-API-DMAC7.html)
DE (1) DE69900220T2 (cg-RX-API-DMAC7.html)
DK (1) DK0970957T3 (cg-RX-API-DMAC7.html)
ES (1) ES2162503T3 (cg-RX-API-DMAC7.html)
HR (1) HRP990188A2 (cg-RX-API-DMAC7.html)
HU (1) HU220894B1 (cg-RX-API-DMAC7.html)
ID (1) ID23304A (cg-RX-API-DMAC7.html)
IL (1) IL130377A0 (cg-RX-API-DMAC7.html)
MA (1) MA26644A1 (cg-RX-API-DMAC7.html)
NO (1) NO312590B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ336189A (cg-RX-API-DMAC7.html)
PE (1) PE20000548A1 (cg-RX-API-DMAC7.html)
PL (1) PL333695A1 (cg-RX-API-DMAC7.html)
PT (1) PT970957E (cg-RX-API-DMAC7.html)
SG (1) SG79259A1 (cg-RX-API-DMAC7.html)
SI (1) SI0970957T1 (cg-RX-API-DMAC7.html)
TR (1) TR199901381A2 (cg-RX-API-DMAC7.html)
YU (1) YU26499A (cg-RX-API-DMAC7.html)
ZA (1) ZA993852B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP4056977B2 (ja) 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
DK1519939T5 (da) * 2002-07-05 2011-01-24 Targacept Inc N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf
JP4712384B2 (ja) * 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
JP2008510711A (ja) * 2004-08-20 2008-04-10 ターガセプト，インコーポレイテッド 嗜癖治療におけるｎ−アリールジアザスピラ環状化合物の使用
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
US8703948B2 (en) * 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CA2683598C (en) * 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
TW202340202A (zh) * 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
AU3498799A (en) 1999-12-23
HUP9901911A1 (hu) 2000-05-28
TR199901381A3 (tr) 2000-01-21
SI0970957T1 (cg-RX-API-DMAC7.html) 2001-12-31
PL333695A1 (en) 1999-12-20
KR20000006060A (ko) 2000-01-25
AU743983B2 (en) 2002-02-14
MA26644A1 (fr) 2004-12-20
ID23304A (id) 2000-04-05
NO992873D0 (no) 1999-06-11
JP3286268B2 (ja) 2002-05-27
NO992873L (no) 1999-12-13
SG79259A1 (en) 2001-03-20
DE69900220T2 (de) 2002-05-08
HU220894B1 (en) 2002-06-29
ES2162503T3 (es) 2001-12-16
NO312590B1 (no) 2002-06-03
HU9901911D0 (en) 1999-08-30
EP0970957A1 (en) 2000-01-12
IL130377A0 (en) 2000-06-01
CN1242366A (zh) 2000-01-26
AR019859A1 (es) 2002-03-20
KR100344732B1 (ko) 2002-07-19
PE20000548A1 (es) 2000-07-15
YU26499A (sh) 2002-09-19
PT970957E (pt) 2002-02-28
JP2000053679A (ja) 2000-02-22
ZA993852B (en) 1999-12-13
NZ336189A (en) 2000-10-27
US6113527A (en) 2000-09-05
TR199901381A2 (xx) 2000-01-21
CN1107066C (zh) 2003-04-30
DK0970957T3 (da) 2001-12-03
HRP990188A2 (en) 2000-02-29
ATE204279T1 (de) 2001-09-15
BR9902651A (pt) 2000-05-16
EP0970957B1 (en) 2001-08-16
DE69900220D1 (de) 2001-09-20

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued