DK0970957T3 - Diaza-spiro[3.5]nonan-derivativer - Google Patents

Diaza-spiro[3.5]nonan-derivativer

Info

Publication number
DK0970957T3
DK0970957T3 DK99110943T DK99110943T DK0970957T3 DK 0970957 T3 DK0970957 T3 DK 0970957T3 DK 99110943 T DK99110943 T DK 99110943T DK 99110943 T DK99110943 T DK 99110943T DK 0970957 T3 DK0970957 T3 DK 0970957T3
Authority
DK
Denmark
Prior art keywords
diazaspiro
nonane derivatives
nonane
derivatives
Prior art date
Application number
DK99110943T
Other languages
Danish (da)
English (en)
Inventor
Geo Adam
Andrea Cesura
Francois Jenck
Sabine Kolczewski
Stephan Roever
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0970957T3 publication Critical patent/DK0970957T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DK99110943T 1998-06-12 1999-06-07 Diaza-spiro[3.5]nonan-derivativer DK0970957T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (1)

Publication Number Publication Date
DK0970957T3 true DK0970957T3 (da) 2001-12-03

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99110943T DK0970957T3 (da) 1998-06-12 1999-06-07 Diaza-spiro[3.5]nonan-derivativer

Country Status (28)

Country Link
US (1) US6113527A (cg-RX-API-DMAC7.html)
EP (1) EP0970957B1 (cg-RX-API-DMAC7.html)
JP (1) JP3286268B2 (cg-RX-API-DMAC7.html)
KR (1) KR100344732B1 (cg-RX-API-DMAC7.html)
CN (1) CN1107066C (cg-RX-API-DMAC7.html)
AR (1) AR019859A1 (cg-RX-API-DMAC7.html)
AT (1) ATE204279T1 (cg-RX-API-DMAC7.html)
AU (1) AU743983B2 (cg-RX-API-DMAC7.html)
BR (1) BR9902651A (cg-RX-API-DMAC7.html)
CA (1) CA2274202A1 (cg-RX-API-DMAC7.html)
DE (1) DE69900220T2 (cg-RX-API-DMAC7.html)
DK (1) DK0970957T3 (cg-RX-API-DMAC7.html)
ES (1) ES2162503T3 (cg-RX-API-DMAC7.html)
HR (1) HRP990188A2 (cg-RX-API-DMAC7.html)
HU (1) HU220894B1 (cg-RX-API-DMAC7.html)
ID (1) ID23304A (cg-RX-API-DMAC7.html)
IL (1) IL130377A0 (cg-RX-API-DMAC7.html)
MA (1) MA26644A1 (cg-RX-API-DMAC7.html)
NO (1) NO312590B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ336189A (cg-RX-API-DMAC7.html)
PE (1) PE20000548A1 (cg-RX-API-DMAC7.html)
PL (1) PL333695A1 (cg-RX-API-DMAC7.html)
PT (1) PT970957E (cg-RX-API-DMAC7.html)
SG (1) SG79259A1 (cg-RX-API-DMAC7.html)
SI (1) SI0970957T1 (cg-RX-API-DMAC7.html)
TR (1) TR199901381A2 (cg-RX-API-DMAC7.html)
YU (1) YU26499A (cg-RX-API-DMAC7.html)
ZA (1) ZA993852B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター1アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP4056977B2 (ja) 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
DK1519939T5 (da) * 2002-07-05 2011-01-24 Targacept Inc N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf
JP4712384B2 (ja) * 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Orl−1受容体介在障害の治療に有用なヒドロキシアルキル置換1,3,8−トリアザスピロ[4.5]デカン−4−オン誘導体
GB0323204D0 (en) * 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
JP2008510711A (ja) * 2004-08-20 2008-04-10 ターガセプト,インコーポレイテッド 嗜癖治療におけるn−アリールジアザスピラ環状化合物の使用
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
US8703948B2 (en) * 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CA2683598C (en) * 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
TW202340202A (zh) * 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
AU3498799A (en) 1999-12-23
HUP9901911A1 (hu) 2000-05-28
TR199901381A3 (tr) 2000-01-21
SI0970957T1 (cg-RX-API-DMAC7.html) 2001-12-31
PL333695A1 (en) 1999-12-20
KR20000006060A (ko) 2000-01-25
AU743983B2 (en) 2002-02-14
MA26644A1 (fr) 2004-12-20
ID23304A (id) 2000-04-05
NO992873D0 (no) 1999-06-11
JP3286268B2 (ja) 2002-05-27
NO992873L (no) 1999-12-13
SG79259A1 (en) 2001-03-20
DE69900220T2 (de) 2002-05-08
HU220894B1 (en) 2002-06-29
ES2162503T3 (es) 2001-12-16
NO312590B1 (no) 2002-06-03
HU9901911D0 (en) 1999-08-30
CA2274202A1 (en) 1999-12-12
EP0970957A1 (en) 2000-01-12
IL130377A0 (en) 2000-06-01
CN1242366A (zh) 2000-01-26
AR019859A1 (es) 2002-03-20
KR100344732B1 (ko) 2002-07-19
PE20000548A1 (es) 2000-07-15
YU26499A (sh) 2002-09-19
PT970957E (pt) 2002-02-28
JP2000053679A (ja) 2000-02-22
ZA993852B (en) 1999-12-13
NZ336189A (en) 2000-10-27
US6113527A (en) 2000-09-05
TR199901381A2 (xx) 2000-01-21
CN1107066C (zh) 2003-04-30
HRP990188A2 (en) 2000-02-29
ATE204279T1 (de) 2001-09-15
BR9902651A (pt) 2000-05-16
EP0970957B1 (en) 2001-08-16
DE69900220D1 (de) 2001-09-20

Similar Documents

Publication Publication Date Title
DE69800896D1 (de) 8-substituierte-1,3,8-Triazaspiro[4,5]decan-4-onderivate
NO20020391D0 (no) 8-Fenyl-6,9-dihydro-[1,2,4]-triazolo-[3,4-i]-purin-5-on- derivater
DE122011100004I1 (de) Triazolo[4,5-D]pyrimidin-derivate.
IS4570A (is) Imidazó[1,2-a]pýridín afleiður
IS2461B (is) Pýrróló [2,3-dl]pýrimídín efnasambönd
CZ20011556A3 (cs) Pyrazolopyridinové deriváty
DE60005850D1 (de) Imidazo[1,2-a]pyridin- und pyrazolo[2,3-a]pyridinderivate
ZA979593B (en) Naphthyridine derivatives.
DE69804273D1 (de) 5h-Thiazolo[3,2-a]pyrimidinderivate
DK0921125T3 (da) 1,3,8-triazaspiro[4.5]decan-4-on-derivater
DK0970957T3 (da) Diaza-spiro[3.5]nonan-derivativer
NO20011638D0 (no) Imidazo[4,5-c]pyridin-4-on-derivater med faktor Xa- inhiberende virkning
NO20013384D0 (no) Imidazo[4,5-c]pyridin-4-on-derivater
AU5065999A (en) Naphthyridine derivatives
FI971310L (fi) 2,7-substituoituja oktahydro-1H-pyrido/1,2-a/pyratsiinijohdannaisia
HUP0003692A3 (en) Pyrimido[4,5-b]indolyl-alkanecarboxamide derivatives
DE69905798D1 (de) Di- oder Triazaspiro[4,5]decanderivate
ID23283A (id) SPIRO [PIPERIDINA-4,1'-PIROLO (3,4-c) PIROLO]
PT1010699E (pt) Derivados de 3-oxadiazolil-1,6-naftiridina-2(h)-ona substituido em 5
FI963073A7 (fi) Makrosykliset difluorisatonijohdannaiset, jotka ovat käyttökelpoisia v iruksia vastustavina aineina
ZA966559B (en) Imidazopyridine derivatives.