CA2272063C - Antithrombotic organic nitrates - Google Patents
Antithrombotic organic nitrates Download PDFInfo
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- CA2272063C CA2272063C CA002272063A CA2272063A CA2272063C CA 2272063 C CA2272063 C CA 2272063C CA 002272063 A CA002272063 A CA 002272063A CA 2272063 A CA2272063 A CA 2272063A CA 2272063 C CA2272063 C CA 2272063C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI96A002368 | 1996-11-14 | ||
| IT96MI002368A IT1295694B1 (it) | 1996-11-14 | 1996-11-14 | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| PCT/EP1997/006311 WO1998021193A1 (en) | 1996-11-14 | 1997-11-12 | Antithrombotic organic nitrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2272063A1 CA2272063A1 (en) | 1998-05-22 |
| CA2272063C true CA2272063C (en) | 2008-05-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002272063A Expired - Fee Related CA2272063C (en) | 1996-11-14 | 1997-11-12 | Antithrombotic organic nitrates |
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|---|---|
| US (1) | US6242432B1 (https=) |
| EP (1) | EP0941218B1 (https=) |
| JP (1) | JP4264137B2 (https=) |
| KR (1) | KR100504122B1 (https=) |
| CN (1) | CN1094931C (https=) |
| AT (1) | ATE226199T1 (https=) |
| AU (1) | AU729423B2 (https=) |
| BR (1) | BR9712959B1 (https=) |
| CA (1) | CA2272063C (https=) |
| DE (1) | DE69716461T2 (https=) |
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| ES (1) | ES2186013T3 (https=) |
| HU (1) | HUP0000667A3 (https=) |
| IL (1) | IL129768A (https=) |
| IT (1) | IT1295694B1 (https=) |
| PT (1) | PT941218E (https=) |
| RU (1) | RU2190594C2 (https=) |
| WO (1) | WO1998021193A1 (https=) |
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| GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
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| IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IE20000052A1 (en) * | 1999-04-29 | 2000-11-29 | Russinsky Ltd | Nitric acid salts of B-blockers |
| IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| AU7365900A (en) | 1999-09-08 | 2001-04-10 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
| US7708989B2 (en) | 1999-10-29 | 2010-05-04 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| US7537785B2 (en) * | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
| US6635273B1 (en) | 1999-10-29 | 2003-10-21 | Trustees Of Boston University | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| CA2393724A1 (en) * | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| WO2001061043A2 (en) | 2000-02-16 | 2001-08-23 | Illumina, Inc. | Parallel genotyping of multiple patient samples |
| CA2410632A1 (en) | 2000-06-22 | 2001-12-27 | David S. Garvey | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| AU5939901A (en) * | 2000-10-27 | 2002-05-06 | Nitromed Inc | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| US7011854B2 (en) | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
| US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
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| US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
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| WO2004047837A2 (en) * | 2002-11-22 | 2004-06-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-blockers having antioxidant and nitric oxide-donor activity |
| US20060166894A1 (en) * | 2002-11-29 | 2006-07-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Ace-inhibitors having antioxidant and no-donor activity |
| US20070207217A1 (en) * | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
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| JP2007502831A (ja) * | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
| BRPI0417182A (pt) * | 2003-12-02 | 2007-03-06 | Nicox Sa | composto e/ou os enantiÈmeros, diastereoisÈmeros e sais farmaceuticamente aceitáveis do mesmo, uso do mesmo, e, composição farmacêutica |
| RU2006119528A (ru) * | 2003-12-02 | 2008-01-10 | Никокс С.А. (Fr) | Нитрооксипроизводные карведилола и других бета-блокаторов в качестве антигипертензивных средств |
| MXPA06007678A (es) * | 2004-01-05 | 2006-09-01 | Nicox Sa | Nitroxiderivados de prostaglandinas. |
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| CN102015682B (zh) * | 2008-05-05 | 2014-07-16 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的3,4-取代的哌啶衍生物 |
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| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| MX2019005321A (es) | 2016-11-08 | 2019-10-14 | Bausch & Lomb | Derivados de prostaglandina que liberan oxido nitrico para el tratamiento de glaucoma de tension normal. |
| AU2020300002A1 (en) | 2019-07-01 | 2022-02-24 | Tonix Pharma Limited | Anti-CD154 antibodies and uses thereof |
| US20240059781A1 (en) | 2021-01-06 | 2024-02-22 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
| CN118146175A (zh) * | 2024-02-07 | 2024-06-07 | 广州楷石生物科技有限公司 | 右旋噻吗洛尔衍生物及其制备方法和应用 |
| WO2025248134A1 (en) | 2024-05-31 | 2025-12-04 | Tonix Pharma Limited | Treatment methods comprising administration of modified cd154 antibodies |
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|---|---|---|---|---|
| IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| ES2065291B1 (es) * | 1993-07-30 | 1995-10-01 | Prodesfarma Sa | "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente" |
| DE69412109T2 (de) | 1993-10-06 | 1999-01-21 | Nicox S.A., Paris | Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung |
| SI0759899T1 (en) * | 1994-05-10 | 1999-12-31 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
| WO1997031896A1 (en) * | 1996-03-01 | 1997-09-04 | Sankyo Company, Limited | Thiazolidine derivatives |
-
1996
- 1996-11-14 IT IT96MI002368A patent/IT1295694B1/it active IP Right Grant
-
1997
- 1997-11-12 RU RU99112517/04A patent/RU2190594C2/ru not_active IP Right Cessation
- 1997-11-12 US US09/297,933 patent/US6242432B1/en not_active Expired - Fee Related
- 1997-11-12 WO PCT/EP1997/006311 patent/WO1998021193A1/en not_active Ceased
- 1997-11-12 JP JP52217998A patent/JP4264137B2/ja not_active Expired - Fee Related
- 1997-11-12 DE DE69716461T patent/DE69716461T2/de not_active Expired - Lifetime
- 1997-11-12 AT AT97951890T patent/ATE226199T1/de active
- 1997-11-12 CN CN97181245A patent/CN1094931C/zh not_active Expired - Fee Related
- 1997-11-12 HU HU0000667A patent/HUP0000667A3/hu unknown
- 1997-11-12 IL IL12976897A patent/IL129768A/en not_active IP Right Cessation
- 1997-11-12 EP EP97951890A patent/EP0941218B1/en not_active Expired - Lifetime
- 1997-11-12 DK DK97951890T patent/DK0941218T3/da active
- 1997-11-12 ES ES97951890T patent/ES2186013T3/es not_active Expired - Lifetime
- 1997-11-12 AU AU55519/98A patent/AU729423B2/en not_active Ceased
- 1997-11-12 CA CA002272063A patent/CA2272063C/en not_active Expired - Fee Related
- 1997-11-12 KR KR10-1999-7004229A patent/KR100504122B1/ko not_active Expired - Fee Related
- 1997-11-12 BR BRPI9712959-3A patent/BR9712959B1/pt not_active IP Right Cessation
- 1997-11-12 PT PT97951890T patent/PT941218E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0941218T3 (da) | 2003-02-17 |
| CA2272063A1 (en) | 1998-05-22 |
| BR9712959A (pt) | 2000-02-01 |
| HUP0000667A3 (en) | 2000-08-28 |
| CN1094931C (zh) | 2002-11-27 |
| ITMI962368A0 (it) | 1996-11-14 |
| JP4264137B2 (ja) | 2009-05-13 |
| IL129768A (en) | 2004-02-19 |
| DE69716461T2 (de) | 2003-06-26 |
| KR100504122B1 (ko) | 2005-07-27 |
| EP0941218B1 (en) | 2002-10-16 |
| CN1242768A (zh) | 2000-01-26 |
| US6242432B1 (en) | 2001-06-05 |
| PT941218E (pt) | 2003-03-31 |
| JP2001507676A (ja) | 2001-06-12 |
| WO1998021193A1 (en) | 1998-05-22 |
| DE69716461D1 (de) | 2002-11-21 |
| RU2190594C2 (ru) | 2002-10-10 |
| EP0941218A1 (en) | 1999-09-15 |
| IT1295694B1 (it) | 1999-05-27 |
| KR20000053251A (ko) | 2000-08-25 |
| ITMI962368A1 (it) | 1998-05-14 |
| BR9712959B1 (pt) | 2010-06-01 |
| AU5551998A (en) | 1998-06-03 |
| IL129768A0 (en) | 2000-02-29 |
| HUP0000667A2 (en) | 2000-07-28 |
| AU729423B2 (en) | 2001-02-01 |
| ATE226199T1 (de) | 2002-11-15 |
| ES2186013T3 (es) | 2003-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20121113 |