IT1295694B1 - Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica - Google Patents

Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica

Info

Publication number
IT1295694B1
IT1295694B1 IT96MI002368A ITMI962368A IT1295694B1 IT 1295694 B1 IT1295694 B1 IT 1295694B1 IT 96MI002368 A IT96MI002368 A IT 96MI002368A IT MI962368 A ITMI962368 A IT MI962368A IT 1295694 B1 IT1295694 B1 IT 1295694B1
Authority
IT
Italy
Prior art keywords
preparation
medications
thrombinic
nitroxis
derivatives
Prior art date
Application number
IT96MI002368A
Other languages
English (en)
Italian (it)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ITMI962368A0 publication Critical patent/ITMI962368A0/it
Priority to IT96MI002368A priority Critical patent/IT1295694B1/it
Priority to KR10-1999-7004229A priority patent/KR100504122B1/ko
Priority to RU99112517/04A priority patent/RU2190594C2/ru
Priority to PT97951890T priority patent/PT941218E/pt
Priority to CN97181245A priority patent/CN1094931C/zh
Priority to JP52217998A priority patent/JP4264137B2/ja
Priority to IL12976897A priority patent/IL129768A/en
Priority to US09/297,933 priority patent/US6242432B1/en
Priority to PCT/EP1997/006311 priority patent/WO1998021193A1/en
Priority to CA002272063A priority patent/CA2272063C/en
Priority to HU0000667A priority patent/HUP0000667A3/hu
Priority to DE69716461T priority patent/DE69716461T2/de
Priority to BRPI9712959-3A priority patent/BR9712959B1/pt
Priority to AU55519/98A priority patent/AU729423B2/en
Priority to DK97951890T priority patent/DK0941218T3/da
Priority to EP97951890A priority patent/EP0941218B1/en
Priority to AT97951890T priority patent/ATE226199T1/de
Priority to SI9730450T priority patent/SI0941218T1/xx
Priority to ES97951890T priority patent/ES2186013T3/es
Publication of ITMI962368A1 publication Critical patent/ITMI962368A1/it
Application granted granted Critical
Publication of IT1295694B1 publication Critical patent/IT1295694B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Peptides Or Proteins (AREA)
IT96MI002368A 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica IT1295694B1 (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
HU0000667A HUP0000667A3 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
BRPI9712959-3A BR9712959B1 (pt) 1996-11-14 1997-11-12 nitratos orgánicos anti-trombóticos de inibidores da ace.
PT97951890T PT941218E (pt) 1996-11-14 1997-11-12 Nitratos organicos antitromboticos
CN97181245A CN1094931C (zh) 1996-11-14 1997-11-12 抗血栓有机硝酸酯
JP52217998A JP4264137B2 (ja) 1996-11-14 1997-11-12 抗血栓性有機硝酸塩
IL12976897A IL129768A (en) 1996-11-14 1997-11-12 Organic nitrates and anticoagulants containing them
US09/297,933 US6242432B1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
PCT/EP1997/006311 WO1998021193A1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
CA002272063A CA2272063C (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
KR10-1999-7004229A KR100504122B1 (ko) 1996-11-14 1997-11-12 항혈전성 유기질산염
DE69716461T DE69716461T2 (de) 1996-11-14 1997-11-12 Antithrombotische organische nitrate
RU99112517/04A RU2190594C2 (ru) 1996-11-14 1997-11-12 Органические нитраты и фармацевтическая композиция, обладающая ингибирующей агрегацию тромбоцитов активностью, на их основе
AU55519/98A AU729423B2 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
DK97951890T DK0941218T3 (da) 1996-11-14 1997-11-12 Antithrombotiske organiske nitrater
EP97951890A EP0941218B1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
AT97951890T ATE226199T1 (de) 1996-11-14 1997-11-12 Antithrombotische organische nitrate
SI9730450T SI0941218T1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
ES97951890T ES2186013T3 (es) 1996-11-14 1997-11-12 Nitratos organicos con actividad antitrombotica.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica

Publications (3)

Publication Number Publication Date
ITMI962368A0 ITMI962368A0 (it) 1996-11-14
ITMI962368A1 ITMI962368A1 (it) 1998-05-14
IT1295694B1 true IT1295694B1 (it) 1999-05-27

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica

Country Status (18)

Country Link
US (1) US6242432B1 (https=)
EP (1) EP0941218B1 (https=)
JP (1) JP4264137B2 (https=)
KR (1) KR100504122B1 (https=)
CN (1) CN1094931C (https=)
AT (1) ATE226199T1 (https=)
AU (1) AU729423B2 (https=)
BR (1) BR9712959B1 (https=)
CA (1) CA2272063C (https=)
DE (1) DE69716461T2 (https=)
DK (1) DK0941218T3 (https=)
ES (1) ES2186013T3 (https=)
HU (1) HUP0000667A3 (https=)
IL (1) IL129768A (https=)
IT (1) IT1295694B1 (https=)
PT (1) PT941218E (https=)
RU (1) RU2190594C2 (https=)
WO (1) WO1998021193A1 (https=)

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IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
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IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
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US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) * 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US6635273B1 (en) 1999-10-29 2003-10-21 Trustees Of Boston University Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
CA2393724A1 (en) * 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
WO2001061043A2 (en) 2000-02-16 2001-08-23 Illumina, Inc. Parallel genotyping of multiple patient samples
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
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US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
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US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
ATE424199T1 (de) 2003-06-19 2009-03-15 Nicox Sa Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen
JP2007502831A (ja) * 2003-08-20 2007-02-15 ニトロメッド インコーポレーティッド ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法
BRPI0417182A (pt) * 2003-12-02 2007-03-06 Nicox Sa composto e/ou os enantiÈmeros, diastereoisÈmeros e sais farmaceuticamente aceitáveis do mesmo, uso do mesmo, e, composição farmacêutica
RU2006119528A (ru) * 2003-12-02 2008-01-10 Никокс С.А. (Fr) Нитрооксипроизводные карведилола и других бета-блокаторов в качестве антигипертензивных средств
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US20080306041A1 (en) * 2005-01-21 2008-12-11 Garvey David S Cardiovascular Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use
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CN102015682B (zh) * 2008-05-05 2014-07-16 埃科特莱茵药品有限公司 作为肾素抑制剂的3,4-取代的哌啶衍生物
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IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
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WO1997031896A1 (en) * 1996-03-01 1997-09-04 Sankyo Company, Limited Thiazolidine derivatives

Also Published As

Publication number Publication date
DK0941218T3 (da) 2003-02-17
CA2272063A1 (en) 1998-05-22
BR9712959A (pt) 2000-02-01
HUP0000667A3 (en) 2000-08-28
CN1094931C (zh) 2002-11-27
ITMI962368A0 (it) 1996-11-14
JP4264137B2 (ja) 2009-05-13
IL129768A (en) 2004-02-19
DE69716461T2 (de) 2003-06-26
KR100504122B1 (ko) 2005-07-27
EP0941218B1 (en) 2002-10-16
CN1242768A (zh) 2000-01-26
US6242432B1 (en) 2001-06-05
PT941218E (pt) 2003-03-31
JP2001507676A (ja) 2001-06-12
WO1998021193A1 (en) 1998-05-22
DE69716461D1 (de) 2002-11-21
RU2190594C2 (ru) 2002-10-10
CA2272063C (en) 2008-05-27
EP0941218A1 (en) 1999-09-15
KR20000053251A (ko) 2000-08-25
ITMI962368A1 (it) 1998-05-14
BR9712959B1 (pt) 2010-06-01
AU5551998A (en) 1998-06-03
IL129768A0 (en) 2000-02-29
HUP0000667A2 (en) 2000-07-28
AU729423B2 (en) 2001-02-01
ATE226199T1 (de) 2002-11-15
ES2186013T3 (es) 2003-05-01

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