BR9712959B1 - nitratos orgánicos anti-trombóticos de inibidores da ace. - Google Patents

nitratos orgánicos anti-trombóticos de inibidores da ace.

Info

Publication number
BR9712959B1
BR9712959B1 BRPI9712959-3A BR9712959A BR9712959B1 BR 9712959 B1 BR9712959 B1 BR 9712959B1 BR 9712959 A BR9712959 A BR 9712959A BR 9712959 B1 BR9712959 B1 BR 9712959B1
Authority
BR
Brazil
Prior art keywords
thrombotic
ace inhibitors
organic nitrates
compounds
nitrates
Prior art date
Application number
BRPI9712959-3A
Other languages
English (en)
Portuguese (pt)
Other versions
BR9712959A (pt
Inventor
Soldato Piero Del
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9712959A publication Critical patent/BR9712959A/pt
Publication of BR9712959B1 publication Critical patent/BR9712959B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Peptides Or Proteins (AREA)
BRPI9712959-3A 1996-11-14 1997-11-12 nitratos orgánicos anti-trombóticos de inibidores da ace. BR9712959B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
PCT/EP1997/006311 WO1998021193A1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates

Publications (2)

Publication Number Publication Date
BR9712959A BR9712959A (pt) 2000-02-01
BR9712959B1 true BR9712959B1 (pt) 2010-06-01

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9712959-3A BR9712959B1 (pt) 1996-11-14 1997-11-12 nitratos orgánicos anti-trombóticos de inibidores da ace.

Country Status (18)

Country Link
US (1) US6242432B1 (https=)
EP (1) EP0941218B1 (https=)
JP (1) JP4264137B2 (https=)
KR (1) KR100504122B1 (https=)
CN (1) CN1094931C (https=)
AT (1) ATE226199T1 (https=)
AU (1) AU729423B2 (https=)
BR (1) BR9712959B1 (https=)
CA (1) CA2272063C (https=)
DE (1) DE69716461T2 (https=)
DK (1) DK0941218T3 (https=)
ES (1) ES2186013T3 (https=)
HU (1) HUP0000667A3 (https=)
IL (1) IL129768A (https=)
IT (1) IT1295694B1 (https=)
PT (1) PT941218E (https=)
RU (1) RU2190594C2 (https=)
WO (1) WO1998021193A1 (https=)

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US6635273B1 (en) 1999-10-29 2003-10-21 Trustees Of Boston University Methods of treating vascular diseases characterized by nitric oxide insufficiency
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US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7499806B2 (en) 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
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US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
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US20060166894A1 (en) * 2002-11-29 2006-07-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
ATE424199T1 (de) 2003-06-19 2009-03-15 Nicox Sa Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen
JP2007502831A (ja) * 2003-08-20 2007-02-15 ニトロメッド インコーポレーティッド ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法
BRPI0417182A (pt) * 2003-12-02 2007-03-06 Nicox Sa composto e/ou os enantiÈmeros, diastereoisÈmeros e sais farmaceuticamente aceitáveis do mesmo, uso do mesmo, e, composição farmacêutica
RU2006119528A (ru) * 2003-12-02 2008-01-10 Никокс С.А. (Fr) Нитрооксипроизводные карведилола и других бета-блокаторов в качестве антигипертензивных средств
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AU2007217980A1 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
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RU2322972C1 (ru) * 2006-09-12 2008-04-27 Илья Николаевич Медведев Способ профилактики тромбозов у больных артериальной гипертонией с метаболическим синдромом
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CN102015682B (zh) * 2008-05-05 2014-07-16 埃科特莱茵药品有限公司 作为肾素抑制剂的3,4-取代的哌啶衍生物
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IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
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Also Published As

Publication number Publication date
DK0941218T3 (da) 2003-02-17
CA2272063A1 (en) 1998-05-22
BR9712959A (pt) 2000-02-01
HUP0000667A3 (en) 2000-08-28
CN1094931C (zh) 2002-11-27
ITMI962368A0 (it) 1996-11-14
JP4264137B2 (ja) 2009-05-13
IL129768A (en) 2004-02-19
DE69716461T2 (de) 2003-06-26
KR100504122B1 (ko) 2005-07-27
EP0941218B1 (en) 2002-10-16
CN1242768A (zh) 2000-01-26
US6242432B1 (en) 2001-06-05
PT941218E (pt) 2003-03-31
JP2001507676A (ja) 2001-06-12
WO1998021193A1 (en) 1998-05-22
DE69716461D1 (de) 2002-11-21
RU2190594C2 (ru) 2002-10-10
CA2272063C (en) 2008-05-27
EP0941218A1 (en) 1999-09-15
IT1295694B1 (it) 1999-05-27
KR20000053251A (ko) 2000-08-25
ITMI962368A1 (it) 1998-05-14
AU5551998A (en) 1998-06-03
IL129768A0 (en) 2000-02-29
HUP0000667A2 (en) 2000-07-28
AU729423B2 (en) 2001-02-01
ATE226199T1 (de) 2002-11-15
ES2186013T3 (es) 2003-05-01

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Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS NA PETICAO NO 020050046572/RJ DE 06/06/2005.

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