PT804418E - Inibidores da agregacao de plaquetas - Google Patents

Inibidores da agregacao de plaquetas

Info

Publication number
PT804418E
PT804418E PT95944838T PT95944838T PT804418E PT 804418 E PT804418 E PT 804418E PT 95944838 T PT95944838 T PT 95944838T PT 95944838 T PT95944838 T PT 95944838T PT 804418 E PT804418 E PT 804418E
Authority
PT
Portugal
Prior art keywords
platelet inhibitors
compounds
platelet aggregation
mammals
inhibition
Prior art date
Application number
PT95944838T
Other languages
English (en)
Inventor
Peter Gerrard Ruminski
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT804418E publication Critical patent/PT804418E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PT95944838T 1995-01-17 1995-12-15 Inibidores da agregacao de plaquetas PT804418E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/375,338 US5602155A (en) 1995-01-17 1995-01-17 Platelet aggregation inhibitors

Publications (1)

Publication Number Publication Date
PT804418E true PT804418E (pt) 2003-08-29

Family

ID=23480498

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95944838T PT804418E (pt) 1995-01-17 1995-12-15 Inibidores da agregacao de plaquetas

Country Status (11)

Country Link
US (2) US5602155A (pt)
EP (1) EP0804418B1 (pt)
JP (1) JPH10512581A (pt)
AT (1) ATE235468T1 (pt)
AU (1) AU5710696A (pt)
CA (1) CA2210746A1 (pt)
DE (1) DE69530123T2 (pt)
DK (1) DK0804418T3 (pt)
ES (1) ES2194933T3 (pt)
PT (1) PT804418E (pt)
WO (1) WO1996023771A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602155A (en) * 1995-01-17 1997-02-11 G. D. Searle & Co. Platelet aggregation inhibitors
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
US6117842A (en) * 1998-03-09 2000-09-12 Merck & Co., Inc. Fibrinogen receptor antagonists
CZ20011872A3 (cs) * 1999-09-29 2002-03-13 Ortho-Mcneil Pharmaceutical, Inc. Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny
JP2004521079A (ja) * 2000-08-29 2004-07-15 ファルマシア・コーポレーション アルファーｖベータ３アンタゴニストとして有用な二環式環系を含有する化合物
US20020072500A1 (en) * 2000-09-27 2002-06-13 Thomas Rogers Hydroxy acid integrin antagonists
US6720327B2 (en) * 2000-09-27 2004-04-13 Pharmacia Corporation Lactone integrin antagonists
JP2004529918A (ja) * 2001-04-09 2004-09-30 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物
US20040019206A1 (en) * 2001-09-27 2004-01-29 Peter Ruminiski Lactone integrin antagonists
WO2003050261A2 (en) 2001-12-10 2003-06-19 Bristol-Myers Squibb Company (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
EP1572210A1 (en) * 2002-12-20 2005-09-14 Pharmacia Corporation The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
MX2015000794A (es) 2012-07-18 2015-10-12 Univ Saint Louis Derivados de aminoácido beta como antagonistas de integrina.
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
CN108779077A (zh) 2015-12-30 2018-11-09 圣路易斯大学 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
AU646411B2 (en) * 1989-09-29 1994-02-24 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
EP0570507A4 (en) * 1991-02-05 1994-09-21 Smithkline Beecham Corp Anti-aggregatory peptides containing an aromatic ester or amide
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
JPH07503944A (ja) * 1991-11-22 1995-04-27 イエダ　リサーチ　アンド　デベロツプメント　カンパニー　リミテツド Ａｒｇ−ｇｌｙ−ａｓｐ配列の非ペプチド代替物およびそれらからなる医薬組成物
US5614539A (en) * 1993-03-15 1997-03-25 G. D. Searle & Co. Urea compounds which are useful as platelet aggregation inhibitors
US5602155A (en) * 1995-01-17 1997-02-11 G. D. Searle & Co. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
US5602155A (en) 1997-02-11
WO1996023771A2 (en) 1996-08-08
EP0804418A2 (en) 1997-11-05
JPH10512581A (ja) 1998-12-02
US5798370A (en) 1998-08-25
CA2210746A1 (en) 1996-08-08
WO1996023771A3 (en) 1996-10-10
ATE235468T1 (de) 2003-04-15
DK0804418T3 (da) 2003-07-07
ES2194933T3 (es) 2003-12-01
DE69530123D1 (en) 2003-04-30
DE69530123T2 (de) 2004-02-05
AU5710696A (en) 1996-08-21
EP0804418B1 (en) 2003-03-26

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