ES2194933T3 - Inhibidores de la agregacion plaquetaria. - Google Patents
Inhibidores de la agregacion plaquetaria.Info
- Publication number
- ES2194933T3 ES2194933T3 ES95944838T ES95944838T ES2194933T3 ES 2194933 T3 ES2194933 T3 ES 2194933T3 ES 95944838 T ES95944838 T ES 95944838T ES 95944838 T ES95944838 T ES 95944838T ES 2194933 T3 ES2194933 T3 ES 2194933T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- aggregation
- compounds
- plaquetary
- plaquetary aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE TIENEN LA FORMULA (I) O A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS QUE SON UTILES EN LA INHIBICION DE LA AGREGACION PLAQUETARIA, A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN EL COMPUESTO Y A UN METODO PARA INHIBIR LA AGREGACION PLAQUETARIA EN MAMIFEROS MEDIANTE AL ADMINISTRACION DE TALES COMPUESTOS Y COMPOSICIONES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/375,338 US5602155A (en) | 1995-01-17 | 1995-01-17 | Platelet aggregation inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194933T3 true ES2194933T3 (es) | 2003-12-01 |
Family
ID=23480498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95944838T Expired - Lifetime ES2194933T3 (es) | 1995-01-17 | 1995-12-15 | Inhibidores de la agregacion plaquetaria. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5602155A (es) |
EP (1) | EP0804418B1 (es) |
JP (1) | JPH10512581A (es) |
AT (1) | ATE235468T1 (es) |
AU (1) | AU5710696A (es) |
CA (1) | CA2210746A1 (es) |
DE (1) | DE69530123T2 (es) |
DK (1) | DK0804418T3 (es) |
ES (1) | ES2194933T3 (es) |
PT (1) | PT804418E (es) |
WO (1) | WO1996023771A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602155A (en) * | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US6087332A (en) * | 1997-12-23 | 2000-07-11 | Galler; Lawrence Isaac | Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy |
US6117842A (en) * | 1998-03-09 | 2000-09-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
CA2352957A1 (en) * | 1999-09-29 | 2001-04-05 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipecotamides for the treatment of integrin-mediated disorders |
US20040058915A1 (en) * | 2000-08-29 | 2004-03-25 | Khanna Ish Kumar | Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists |
US20020072500A1 (en) * | 2000-09-27 | 2002-06-13 | Thomas Rogers | Hydroxy acid integrin antagonists |
US6720327B2 (en) * | 2000-09-27 | 2004-04-13 | Pharmacia Corporation | Lactone integrin antagonists |
EP1389205B1 (en) * | 2001-04-09 | 2005-12-21 | Ortho-McNeil Pharmaceutical Research Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
US20040019206A1 (en) * | 2001-09-27 | 2004-01-29 | Peter Ruminiski | Lactone integrin antagonists |
WO2003050261A2 (en) | 2001-12-10 | 2003-06-19 | Bristol-Myers Squibb Company | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase |
AU2003299600A1 (en) * | 2002-12-20 | 2004-07-29 | Pharmacia Corpration | The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives |
US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
IN2015DN00099A (es) | 2012-07-18 | 2015-05-29 | Univ Saint Louis | |
RU2729518C2 (ru) | 2015-12-30 | 2020-08-07 | Сент-Луис Юниверсити | Мета-азациклические производные аминобензойной кислоты в качестве антагонистов пан-интегрина |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
CA2066047A1 (en) * | 1989-09-29 | 1991-03-30 | Scott I. Klein | Anti-thrombotic peptides and pseudopeptides |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
NZ239876A (en) * | 1990-09-27 | 1993-12-23 | Merck & Co Inc | Glycyl-b-alanine derivatives and pharmaceutical compositions thereof. |
JPH06505978A (ja) * | 1991-02-05 | 1994-07-07 | スミスクライン・ビーチャム・コーポレイション | 芳香族エステルまたはアミドを含有する抗凝集性ペプチド |
MX9201416A (es) * | 1991-03-28 | 1992-10-01 | Rhone Poulenc Rorer Int | Peptidos y pseudopeptidos antitromboticos. |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
CA2117282A1 (en) * | 1991-11-22 | 1993-05-27 | Ofer Lider | Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprosing them |
WO1994021602A1 (en) * | 1993-03-15 | 1994-09-29 | G.D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
US5602155A (en) * | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
-
1995
- 1995-01-17 US US08/375,338 patent/US5602155A/en not_active Expired - Fee Related
- 1995-12-15 WO PCT/US1995/015798 patent/WO1996023771A2/en active IP Right Grant
- 1995-12-15 EP EP95944838A patent/EP0804418B1/en not_active Expired - Lifetime
- 1995-12-15 JP JP8523510A patent/JPH10512581A/ja not_active Ceased
- 1995-12-15 AT AT95944838T patent/ATE235468T1/de not_active IP Right Cessation
- 1995-12-15 DE DE69530123T patent/DE69530123T2/de not_active Expired - Fee Related
- 1995-12-15 PT PT95944838T patent/PT804418E/pt unknown
- 1995-12-15 AU AU57106/96A patent/AU5710696A/en not_active Abandoned
- 1995-12-15 CA CA002210746A patent/CA2210746A1/en not_active Abandoned
- 1995-12-15 DK DK95944838T patent/DK0804418T3/da active
- 1995-12-15 ES ES95944838T patent/ES2194933T3/es not_active Expired - Lifetime
-
1996
- 1996-12-06 US US08/762,823 patent/US5798370A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0804418B1 (en) | 2003-03-26 |
ATE235468T1 (de) | 2003-04-15 |
DE69530123T2 (de) | 2004-02-05 |
CA2210746A1 (en) | 1996-08-08 |
WO1996023771A2 (en) | 1996-08-08 |
US5798370A (en) | 1998-08-25 |
DE69530123D1 (en) | 2003-04-30 |
DK0804418T3 (da) | 2003-07-07 |
JPH10512581A (ja) | 1998-12-02 |
AU5710696A (en) | 1996-08-21 |
PT804418E (pt) | 2003-08-29 |
EP0804418A2 (en) | 1997-11-05 |
US5602155A (en) | 1997-02-11 |
WO1996023771A3 (en) | 1996-10-10 |
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