CA2263671A1 - Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire - Google Patents

Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire Download PDF

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Publication number
CA2263671A1
CA2263671A1 CA002263671A CA2263671A CA2263671A1 CA 2263671 A1 CA2263671 A1 CA 2263671A1 CA 002263671 A CA002263671 A CA 002263671A CA 2263671 A CA2263671 A CA 2263671A CA 2263671 A1 CA2263671 A1 CA 2263671A1
Authority
CA
Canada
Prior art keywords
alkylene
nr9r10
alkyl
compounds
nhr9
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002263671A
Other languages
English (en)
Inventor
Heinke Von Seggern
Werner Kramer
Gunther Wess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Research and Technologies GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2263671A1 publication Critical patent/CA2263671A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne des inhibiteurs polymères d'adsorption d'acide biliaire à effet simultané d'adsorption de l'acide biliaire, un procédé permettant de les préparer, des médicaments contenant lesdits composés et leur utilisation. L'invention concerne des copolymères vinyliques comportant les unités de la formule (I) dans laquelle R?1¿ à R?5¿, d, e, f, H, L, A, Y, Z et B ont la notation mentionnée dans la description, ainsi qu'un procédé permettant des les préparer. Les composés s'utilisent pour traiter des troubles du métabolisme lipidique.
CA002263671A 1996-08-19 1997-07-25 Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire Abandoned CA2263671A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19633268.0 1996-08-19
DE19633268A DE19633268A1 (de) 1996-08-19 1996-08-19 Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
PCT/EP1997/004049 WO1998007449A2 (fr) 1996-08-19 1997-07-25 Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire

Publications (1)

Publication Number Publication Date
CA2263671A1 true CA2263671A1 (fr) 1998-02-26

Family

ID=7802940

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002263671A Abandoned CA2263671A1 (fr) 1996-08-19 1997-07-25 Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire

Country Status (5)

Country Link
EP (1) EP0918544A2 (fr)
JP (1) JP2000517356A (fr)
CA (1) CA2263671A1 (fr)
DE (1) DE19633268A1 (fr)
WO (1) WO1998007449A2 (fr)

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US11685835B2 (en) 2016-05-11 2023-06-27 Sony Corporation Ultra bright dimeric or polymeric dyes
US11827661B2 (en) 2015-02-26 2023-11-28 Sony Group Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
US11931419B2 (en) 2017-11-16 2024-03-19 Sony Group Corporation Programmable polymeric drugs
US11939474B2 (en) 2013-08-22 2024-03-26 Sony Group Corporation Water soluble fluorescent or colored dyes and methods for their use
US11945955B2 (en) 2019-09-26 2024-04-02 Sony Group Corporation Polymeric tandem dyes with linker groups
US11981820B2 (en) 2016-04-01 2024-05-14 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US12006438B2 (en) 2018-06-27 2024-06-11 Sony Group Corporation Polymeric dyes with linker groups comprising deoxyribose
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same

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JP3942846B2 (ja) * 2001-06-21 2007-07-11 独立行政法人科学技術振興機構 組織特異的トランスポーター阻害剤
EP1555327A4 (fr) * 2002-10-16 2006-08-02 Kyowa Medex Co Ltd Procede et reactif servant a mesurer le cholesterol dans des lipoproteines haute densite
SG190433A1 (en) 2010-11-08 2013-06-28 Albireo Ab A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
DK2637668T3 (en) 2010-11-08 2016-08-29 Albireo Ab Ibat inhibitors for the treatment of liver diseases
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
JP6751020B2 (ja) 2014-06-25 2020-09-02 Ｅａファーマ株式会社 固形製剤及びその着色防止又は着色低減方法
EP3012252A1 (fr) 2014-10-24 2016-04-27 Ferring BV Formes crystallines d'Elobixibat
ES2874669T3 (es) 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
RU2750937C2 (ru) 2016-02-09 2021-07-06 Альбирео Аб Пероральный состав холестирамина и его применение
WO2019032026A1 (fr) 2017-08-09 2019-02-14 Albireo Ab Granules de cholestyramine, formulations orales de cholestyramine et leur utilisation
JP7328207B2 (ja) 2017-08-09 2023-08-16 アルビレオ・アクチボラグ コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用
KR20200098618A (ko) * 2017-12-13 2020-08-20 소니 주식회사 생물학적 활성 화합물을 함유하는 이온성 중합체
CA3100113A1 (fr) 2018-06-05 2019-12-12 Albireo Ab Composes de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2019245448A1 (fr) 2018-06-20 2019-12-26 Albireo Ab Modifications cristallines d'odévixibat
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
JP7504110B2 (ja) 2019-02-06 2024-06-21 アルビレオ・アクチボラグ ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
WO2020161217A1 (fr) 2019-02-06 2020-08-13 Albireo Ab Composés de benzothiadiazépine et leur utilisation en tant que modulateurs d'acide biliaire
JP2023504644A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
CN114761079B (zh) 2019-12-04 2024-05-28 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
TW202134220A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2021110887A1 (fr) 2019-12-04 2021-06-10 Albireo Ab Composés de benzothiazépine et leur utilisation en tant que modulateurs de l'acide biliaire
CA3158276A1 (fr) 2019-12-04 2021-06-10 Per-Goran Gillberg Composes de benzothia(di)azepine et leur utilisation en tant que modulateurs d'acide biliaire
JP2023504643A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
TW202134221A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻二氮呯化合物及其作為膽酸調節劑之用途
WO2021110884A1 (fr) 2019-12-04 2021-06-10 Albireo Ab Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs d'acide biliaire
AR120679A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores ácido biliar
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
JP2023537285A (ja) 2020-08-03 2023-08-31 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
AU2021379076A1 (en) 2020-11-12 2023-06-08 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
EP4255565A1 (fr) 2020-12-04 2023-10-11 Albireo AB Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire
WO2023237728A1 (fr) 2022-06-09 2023-12-14 Albireo Ab Traitement de l'hépatite

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OA08092A (fr) * 1984-05-11 1987-03-31 Bristol Myers Co Novel bile sequestrant resin and uses.
FI106800B (fi) * 1990-12-06 2001-04-12 Hoechst Ag Menetelmä uusien terapeuttisesti käyttökelpoisten dimeeristen sappihappojohdannaisten valmistamiseksi
NZ245504A (en) * 1991-12-20 1995-08-28 Hoechst Ag Bile acid derivatives containing an ethylenically unsaturated grouping
US5430116A (en) * 1991-12-20 1995-07-04 Hoechst Aktiengesellschaft Polymers and oligomers of bile acid derivatives, process for their preparation and their use as pharmaceuticals
EP0580078B1 (fr) * 1992-07-22 1997-10-15 Hoechst Aktiengesellschaft Dérivés de polyvinylamine présentant des groupes hydrophiles, leur procédé de préparation et leur application comme médicaments, supports de matières actives et ingrédients pour produits alimentaires
DK0580079T3 (da) * 1992-07-22 1997-06-30 Hoechst Ag Tværbundne, nitrogenholdige vinylcopolymerer, fremgangsmåde til deres fremstilling samt anvendelse af disse forbindelser
DE4234537A1 (de) * 1992-10-14 1994-04-21 Hoechst Ag Zubereitung, enthaltend Insulin und polymere Gallensäure
JPH06321785A (ja) * 1993-05-12 1994-11-22 Sekisui Chem Co Ltd 胆汁酸腸管吸収抑制剤
JPH06329543A (ja) * 1993-05-20 1994-11-29 Sekisui Chem Co Ltd 経口コレステロール低下剤
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11939474B2 (en) 2013-08-22 2024-03-26 Sony Group Corporation Water soluble fluorescent or colored dyes and methods for their use
US11827661B2 (en) 2015-02-26 2023-11-28 Sony Group Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
US11981820B2 (en) 2016-04-01 2024-05-14 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US11685835B2 (en) 2016-05-11 2023-06-27 Sony Corporation Ultra bright dimeric or polymeric dyes
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
US11931419B2 (en) 2017-11-16 2024-03-19 Sony Group Corporation Programmable polymeric drugs
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
US12006438B2 (en) 2018-06-27 2024-06-11 Sony Group Corporation Polymeric dyes with linker groups comprising deoxyribose
US11945955B2 (en) 2019-09-26 2024-04-02 Sony Group Corporation Polymeric tandem dyes with linker groups

Also Published As

Publication number Publication date
DE19633268A1 (de) 1998-02-26
JP2000517356A (ja) 2000-12-26
WO1998007449A3 (fr) 1998-06-25
WO1998007449A2 (fr) 1998-02-26
EP0918544A2 (fr) 1999-06-02

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