CA2263671A1 - Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire - Google Patents
Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire Download PDFInfo
- Publication number
- CA2263671A1 CA2263671A1 CA002263671A CA2263671A CA2263671A1 CA 2263671 A1 CA2263671 A1 CA 2263671A1 CA 002263671 A CA002263671 A CA 002263671A CA 2263671 A CA2263671 A CA 2263671A CA 2263671 A1 CA2263671 A1 CA 2263671A1
- Authority
- CA
- Canada
- Prior art keywords
- alkylene
- nr9r10
- alkyl
- compounds
- nhr9
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
L'invention concerne des inhibiteurs polymères d'adsorption d'acide biliaire à effet simultané d'adsorption de l'acide biliaire, un procédé permettant de les préparer, des médicaments contenant lesdits composés et leur utilisation. L'invention concerne des copolymères vinyliques comportant les unités de la formule (I) dans laquelle R?1¿ à R?5¿, d, e, f, H, L, A, Y, Z et B ont la notation mentionnée dans la description, ainsi qu'un procédé permettant des les préparer. Les composés s'utilisent pour traiter des troubles du métabolisme lipidique.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19633268.0 | 1996-08-19 | ||
DE19633268A DE19633268A1 (de) | 1996-08-19 | 1996-08-19 | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
PCT/EP1997/004049 WO1998007449A2 (fr) | 1996-08-19 | 1997-07-25 | Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2263671A1 true CA2263671A1 (fr) | 1998-02-26 |
Family
ID=7802940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002263671A Abandoned CA2263671A1 (fr) | 1996-08-19 | 1997-07-25 | Inhibiteurs polymeres de resorption d'acide biliaire a effet simultane d'adsorption de l'acide biliaire |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0918544A2 (fr) |
JP (1) | JP2000517356A (fr) |
CA (1) | CA2263671A1 (fr) |
DE (1) | DE19633268A1 (fr) |
WO (1) | WO1998007449A2 (fr) |
Cited By (7)
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---|---|---|---|---|
US11685835B2 (en) | 2016-05-11 | 2023-06-27 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
US11827661B2 (en) | 2015-02-26 | 2023-11-28 | Sony Group Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
US11931419B2 (en) | 2017-11-16 | 2024-03-19 | Sony Group Corporation | Programmable polymeric drugs |
US11939474B2 (en) | 2013-08-22 | 2024-03-26 | Sony Group Corporation | Water soluble fluorescent or colored dyes and methods for their use |
US11945955B2 (en) | 2019-09-26 | 2024-04-02 | Sony Group Corporation | Polymeric tandem dyes with linker groups |
US11981820B2 (en) | 2016-04-01 | 2024-05-14 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3942846B2 (ja) * | 2001-06-21 | 2007-07-11 | 独立行政法人科学技術振興機構 | 組織特異的トランスポーター阻害剤 |
EP1555327A4 (fr) * | 2002-10-16 | 2006-08-02 | Kyowa Medex Co Ltd | Procede et reactif servant a mesurer le cholesterol dans des lipoproteines haute densite |
HUE030062T2 (en) | 2010-11-08 | 2017-04-28 | Albireo Ab | IBAT inhibitors for the treatment of liver diseases |
PT2637646T (pt) | 2010-11-08 | 2016-08-17 | Albireo Ab | Uma combinação farmacêutica que compreende um inibidor do ibat e um sequestrador de ácido biliar |
JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
KR20220082931A (ko) | 2014-06-25 | 2022-06-17 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
EP3012252A1 (fr) | 2014-10-24 | 2016-04-27 | Ferring BV | Formes crystallines d'Elobixibat |
CA3011565C (fr) | 2016-02-09 | 2024-01-02 | Albireo Ab | Formulation orale de cholestyramine et utilisation associee |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
RU2750937C2 (ru) | 2016-02-09 | 2021-07-06 | Альбирео Аб | Пероральный состав холестирамина и его применение |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
CA3071285A1 (fr) | 2017-08-09 | 2019-02-14 | Albireo Ab | Granules de cholestyramine, formulations orales de cholestyramine et leur utilisation |
WO2019032027A1 (fr) | 2017-08-09 | 2019-02-14 | Albireo Ab | Pastilles de cholestyramine, formulations orales de cholestyramine et leur utilisation |
US20210128591A1 (en) * | 2017-12-13 | 2021-05-06 | Sony Corporation | Ionic polymers comprising biologically active compounds |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2019234077A1 (fr) | 2018-06-05 | 2019-12-12 | Albireo Ab | Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs de l'acide biliaire |
PE20210182A1 (es) | 2018-06-20 | 2021-01-29 | Albireo Ab | Modificaciones de cristales de odexibat |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
CN113453753A (zh) | 2019-02-06 | 2021-09-28 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
MX2021008981A (es) | 2019-02-06 | 2021-09-08 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar. |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
CN114761080A (zh) | 2019-12-04 | 2022-07-15 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
TW202134218A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其作為膽酸調節劑之用途 |
TW202134221A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
KR20220109450A (ko) | 2019-12-04 | 2022-08-04 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의 이의 용도 |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
TW202134222A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途 |
EP4069359B1 (fr) | 2019-12-04 | 2024-01-03 | Albireo AB | Composés de benzothia(di)azepine et leur utilisation en tant que modulateurs d'acide biliaire |
AR120679A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores ácido biliar |
WO2021110886A1 (fr) | 2019-12-04 | 2021-06-10 | Albireo Ab | Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs de l'acide biliaire |
CN114761018A (zh) | 2019-12-04 | 2022-07-15 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症(pfic)を処置するためのオデビキシバット |
BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
WO2023237728A1 (fr) | 2022-06-09 | 2023-12-14 | Albireo Ab | Traitement de l'hépatite |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3572985D1 (en) * | 1984-05-11 | 1989-10-19 | Bristol Myers Co | Novel bile sequestrant resin and uses |
DE59108326D1 (de) * | 1990-12-06 | 1996-12-12 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel |
FI108451B (fi) * | 1991-12-20 | 2002-01-31 | Hoechst Ag | Menetelmõ polymeeristen ja oligomeeristen sappihappojohdannaisten valmistamiseksi |
AU664059B2 (en) * | 1991-12-20 | 1995-11-02 | Hoechst Aktiengesellschaft | Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors |
ATE159262T1 (de) * | 1992-07-22 | 1997-11-15 | Hoechst Ag | Hydrophile zentren aufweisende polyvinylamin- derivate, verfahren zu ihrer herstellung sowie die verwendung der verbindungen als arzneimittel, wirkstoffträger und nahrungsmittelhilfsstoff |
ES2096150T3 (es) * | 1992-07-22 | 1997-03-01 | Hoechst Ag | Copolimeros vinilicos reticulados, procedimiento para su preparacion, asi como el empleo de estos compuestos. |
DE4234537A1 (de) * | 1992-10-14 | 1994-04-21 | Hoechst Ag | Zubereitung, enthaltend Insulin und polymere Gallensäure |
JPH06321785A (ja) * | 1993-05-12 | 1994-11-22 | Sekisui Chem Co Ltd | 胆汁酸腸管吸収抑制剤 |
JPH06329543A (ja) * | 1993-05-20 | 1994-11-29 | Sekisui Chem Co Ltd | 経口コレステロール低下剤 |
US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
-
1996
- 1996-08-19 DE DE19633268A patent/DE19633268A1/de not_active Withdrawn
-
1997
- 1997-07-25 EP EP97940028A patent/EP0918544A2/fr not_active Withdrawn
- 1997-07-25 CA CA002263671A patent/CA2263671A1/fr not_active Abandoned
- 1997-07-25 WO PCT/EP1997/004049 patent/WO1998007449A2/fr not_active Application Discontinuation
- 1997-07-25 JP JP10510319A patent/JP2000517356A/ja active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11939474B2 (en) | 2013-08-22 | 2024-03-26 | Sony Group Corporation | Water soluble fluorescent or colored dyes and methods for their use |
US11827661B2 (en) | 2015-02-26 | 2023-11-28 | Sony Group Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
US11981820B2 (en) | 2016-04-01 | 2024-05-14 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
US11685835B2 (en) | 2016-05-11 | 2023-06-27 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
US11931419B2 (en) | 2017-11-16 | 2024-03-19 | Sony Group Corporation | Programmable polymeric drugs |
US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
US11945955B2 (en) | 2019-09-26 | 2024-04-02 | Sony Group Corporation | Polymeric tandem dyes with linker groups |
Also Published As
Publication number | Publication date |
---|---|
WO1998007449A2 (fr) | 1998-02-26 |
JP2000517356A (ja) | 2000-12-26 |
WO1998007449A3 (fr) | 1998-06-25 |
DE19633268A1 (de) | 1998-02-26 |
EP0918544A2 (fr) | 1999-06-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |