CA2224074C - System and method for producing drug-loaded microparticles - Google Patents

System and method for producing drug-loaded microparticles Download PDF

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Publication number
CA2224074C
CA2224074C CA002224074A CA2224074A CA2224074C CA 2224074 C CA2224074 C CA 2224074C CA 002224074 A CA002224074 A CA 002224074A CA 2224074 A CA2224074 A CA 2224074A CA 2224074 C CA2224074 C CA 2224074C
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CA
Canada
Prior art keywords
icam
drug
alginate
stream
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002224074A
Other languages
English (en)
French (fr)
Other versions
CA2224074A1 (en
Inventor
David C. Bomberger
Paul G. Catz
Mark I. Smedley
Paul C. Stearns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc filed Critical SRI International Inc
Publication of CA2224074A1 publication Critical patent/CA2224074A1/en
Application granted granted Critical
Publication of CA2224074C publication Critical patent/CA2224074C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002224074A 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles Expired - Lifetime CA2224074C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/480,624 US5879712A (en) 1995-06-07 1995-06-07 Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US08/480,624 1995-06-07
PCT/US1996/010031 WO1996040069A1 (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Publications (2)

Publication Number Publication Date
CA2224074A1 CA2224074A1 (en) 1996-12-19
CA2224074C true CA2224074C (en) 2009-09-08

Family

ID=23908687

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224074A Expired - Lifetime CA2224074C (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Country Status (8)

Country Link
US (3) US5879712A (https=)
EP (1) EP0833614B1 (https=)
JP (1) JP4156665B2 (https=)
AT (1) ATE353631T1 (https=)
CA (1) CA2224074C (https=)
DE (1) DE69636904T2 (https=)
ES (1) ES2281084T3 (https=)
WO (1) WO1996040069A1 (https=)

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US6485747B1 (en) * 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
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DE19904785A1 (de) * 1999-02-05 2000-08-10 Ulrich Zimmermann Verfahren zur Herstellung von stabilem Alginatmaterial
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US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
WO2007001448A2 (en) * 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
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EP1933941A2 (en) 2005-08-25 2008-06-25 Philip R. Houle Treatment systems for delivery of sensitizer solutions
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
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WO2007137117A2 (en) * 2006-05-17 2007-11-29 Massachusetts Institute Of Technology Aptamer-directed drug delivery
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008019142A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008031780A2 (de) * 2006-09-13 2008-03-20 Basf Se Verfahren zur herstellung feinteiliger dispersionen
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
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US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
PT2506859T (pt) * 2009-12-04 2016-08-12 Magle Ab Microesferas de amido hidrolisado com ligandos endógenos carregados
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Also Published As

Publication number Publication date
US5879712A (en) 1999-03-09
WO1996040069A1 (en) 1996-12-19
EP0833614B1 (en) 2007-02-14
ES2281084T3 (es) 2007-09-16
ATE353631T1 (de) 2007-03-15
US7087245B2 (en) 2006-08-08
JP4156665B2 (ja) 2008-09-24
JPH11507382A (ja) 1999-06-29
DE69636904D1 (de) 2007-03-29
DE69636904T2 (de) 2007-11-15
US6375985B1 (en) 2002-04-23
EP0833614A4 (en) 2001-07-11
CA2224074A1 (en) 1996-12-19
US20030091649A1 (en) 2003-05-15
EP0833614A1 (en) 1998-04-08

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Effective date: 20160606