ATE353631T1 - System und verfahren zur herstellung arzneistoffbeladener mikropartikel - Google Patents

System und verfahren zur herstellung arzneistoffbeladener mikropartikel

Info

Publication number
ATE353631T1
ATE353631T1 AT96918456T AT96918456T ATE353631T1 AT E353631 T1 ATE353631 T1 AT E353631T1 AT 96918456 T AT96918456 T AT 96918456T AT 96918456 T AT96918456 T AT 96918456T AT E353631 T1 ATE353631 T1 AT E353631T1
Authority
AT
Austria
Prior art keywords
microparticles
emulsion
mixing chamber
drug
linking agent
Prior art date
Application number
AT96918456T
Other languages
English (en)
Inventor
David C Bomberger
Paul G Catz
Mark I Smedley
Paul C Stearns
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Application granted granted Critical
Publication of ATE353631T1 publication Critical patent/ATE353631T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96918456T 1995-06-07 1996-06-06 System und verfahren zur herstellung arzneistoffbeladener mikropartikel ATE353631T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/480,624 US5879712A (en) 1995-06-07 1995-06-07 Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced

Publications (1)

Publication Number Publication Date
ATE353631T1 true ATE353631T1 (de) 2007-03-15

Family

ID=23908687

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96918456T ATE353631T1 (de) 1995-06-07 1996-06-06 System und verfahren zur herstellung arzneistoffbeladener mikropartikel

Country Status (8)

Country Link
US (3) US5879712A (de)
EP (1) EP0833614B1 (de)
JP (1) JP4156665B2 (de)
AT (1) ATE353631T1 (de)
CA (1) CA2224074C (de)
DE (1) DE69636904T2 (de)
ES (1) ES2281084T3 (de)
WO (1) WO1996040069A1 (de)

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PT2301965E (pt) 2002-10-16 2015-05-20 Purdue Pharma Lp Anticorpos que se ligam a ca 125/0722p associado a células e métodos para a sua utilização
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US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
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CA2632183A1 (en) 2005-08-25 2007-03-01 Philip R. Houle Treatment systems for delivery of sensitizer solutions
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
WO2008105773A2 (en) * 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
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US9381477B2 (en) * 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008019142A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008031780A2 (de) * 2006-09-13 2008-03-20 Basf Se Verfahren zur herstellung feinteiliger dispersionen
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
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US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
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KR20160085269A (ko) * 2013-11-13 2016-07-15 틸로츠 파마 아게 다중-미립자 약물전달 시스템
WO2016184450A1 (de) * 2015-05-21 2016-11-24 LÖSLER, Arnold Matrixmembranschicht auf alginatbasis
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Also Published As

Publication number Publication date
EP0833614B1 (de) 2007-02-14
US7087245B2 (en) 2006-08-08
CA2224074C (en) 2009-09-08
ES2281084T3 (es) 2007-09-16
US20030091649A1 (en) 2003-05-15
EP0833614A1 (de) 1998-04-08
JPH11507382A (ja) 1999-06-29
DE69636904T2 (de) 2007-11-15
DE69636904D1 (de) 2007-03-29
EP0833614A4 (de) 2001-07-11
US6375985B1 (en) 2002-04-23
WO1996040069A1 (en) 1996-12-19
CA2224074A1 (en) 1996-12-19
US5879712A (en) 1999-03-09
JP4156665B2 (ja) 2008-09-24

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