IT1291559B1 - Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile - Google Patents

Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile

Info

Publication number
IT1291559B1
IT1291559B1 IT97MI000856A ITMI970856A IT1291559B1 IT 1291559 B1 IT1291559 B1 IT 1291559B1 IT 97MI000856 A IT97MI000856 A IT 97MI000856A IT MI970856 A ITMI970856 A IT MI970856A IT 1291559 B1 IT1291559 B1 IT 1291559B1
Authority
IT
Italy
Prior art keywords
microparticles
protein
pharmaceutical composition
adsorbed
antibody
Prior art date
Application number
IT97MI000856A
Other languages
English (en)
Inventor
Dario Cremaschi
Cristina Porta
Original Assignee
Univ Degli Studi Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI000856A priority Critical patent/IT1291559B1/it
Application filed by Univ Degli Studi Milano filed Critical Univ Degli Studi Milano
Priority to CA002288970A priority patent/CA2288970C/en
Priority to PL98336207A priority patent/PL189918B1/pl
Priority to AU75260/98A priority patent/AU742079B2/en
Priority to DE69815828T priority patent/DE69815828T2/de
Priority to TR1999/02536T priority patent/TR199902536T2/xx
Priority to JP54350598A priority patent/JP2002503222A/ja
Priority to PCT/EP1998/002214 priority patent/WO1998046209A1/en
Priority to EP98922720A priority patent/EP0971703B9/en
Priority to PT98922720T priority patent/PT971703E/pt
Priority to IL13211498A priority patent/IL132114A/en
Priority to DK98922720T priority patent/DK0971703T3/da
Priority to EA199900934A priority patent/EA002324B1/ru
Priority to CNB988041731A priority patent/CN1135970C/zh
Priority to CZ0362499A priority patent/CZ298935B6/cs
Priority to SI9830505T priority patent/SI0971703T1/xx
Priority to HU0001752A priority patent/HU225523B1/hu
Priority to AT98922720T priority patent/ATE243502T1/de
Priority to ES98922720T priority patent/ES2201492T3/es
Priority to GEAP19985071A priority patent/GEP20022646B/en
Priority to KR10-1999-7009351A priority patent/KR100507449B1/ko
Priority to SK1422-99A priority patent/SK282398B6/sk
Priority to UA99116188A priority patent/UA62961C2/uk
Publication of ITMI970856A1 publication Critical patent/ITMI970856A1/it
Publication of IT1291559B1 publication Critical patent/IT1291559B1/it
Application granted granted Critical
Priority to BG103873A priority patent/BG64269B1/bg
Priority to US09/988,150 priority patent/US7235522B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IT97MI000856A 1997-04-14 1997-04-14 Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile IT1291559B1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT97MI000856A IT1291559B1 (it) 1997-04-14 1997-04-14 Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile
KR10-1999-7009351A KR100507449B1 (ko) 1997-04-14 1998-04-08 흡착된 단백질과 항체를 갖는 미세입자를 포함하는 비강내 투여용 약제 조성물
CNB988041731A CN1135970C (zh) 1997-04-14 1998-04-08 具有吸附其上的蛋白质和抗体的微粒在鼻内给药的药物组合物制备中的用途
DE69815828T DE69815828T2 (de) 1997-04-14 1998-04-08 Verwendung von mikropartikeln, auf denen ein protein und ein antikörper adsorbiert sind, zur herstellung eines arzneimittels zur intranasalen verabreichung
TR1999/02536T TR199902536T2 (xx) 1997-04-14 1998-04-08 Burundan i�eri verilmeye mahsus eczac�l��a ait bir terkip haz�rlamak �zere, bir proteini ve bunun �zerine yedirilmi� bir antikoru olan mikro zerrelerin kullan�m�.
JP54350598A JP2002503222A (ja) 1997-04-14 1998-04-08 吸着されたタンパク質および抗体を有する微粒子の、鼻腔内投与用医薬組成物の製造における使用
PCT/EP1998/002214 WO1998046209A1 (en) 1997-04-14 1998-04-08 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
EP98922720A EP0971703B9 (en) 1997-04-14 1998-04-08 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
PT98922720T PT971703E (pt) 1997-04-14 1998-04-08 Utilizacao de microparticulas que possuem uma proteina e um anticorpo adsorvido para preparar uma composicao farmaceutica para administracao intranasal
IL13211498A IL132114A (en) 1997-04-14 1998-04-08 Use of small particles with protein and an antibody attached to them to prepare pharmaceutical preparations for intravenous administration
DK98922720T DK0971703T3 (da) 1997-04-14 1998-04-08 Anvendelse af mikropartikler med et protein og et antistof adsorberet derpå til fremstilling af en farmaceutisk sammensætning til intranasal administration
EA199900934A EA002324B1 (ru) 1997-04-14 1998-04-08 Полимерная микрочастица, содержащая адсорбированные на ней белок и антитело, для получения фармацевтической композиции для интраназального введения
CA002288970A CA2288970C (en) 1997-04-14 1998-04-08 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
AU75260/98A AU742079B2 (en) 1997-04-14 1998-04-08 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
CZ0362499A CZ298935B6 (cs) 1997-04-14 1998-04-08 Použití mikrocástic obsahujících na sobe adsorbovaný protein a protilátku pro prípravu farmaceutického prostredku k intranasálnímu podání
HU0001752A HU225523B1 (en) 1997-04-14 1998-04-08 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
AT98922720T ATE243502T1 (de) 1997-04-14 1998-04-08 Verwendung von mikropartikeln, auf denen ein protein und ein antikörper adsorbiert sind, zur herstellung eines arzneimittels zur intranasalen verabreichung
ES98922720T ES2201492T3 (es) 1997-04-14 1998-04-08 Uso de microparticulas que comprenden una proteina y un anticuerpo adsorbido en la misma para la preparacion de una composicion farmaceutica de administracion intranasal.
GEAP19985071A GEP20022646B (en) 1997-04-14 1998-04-08 Use Of Microparticles Having A Protein And An Antibody Adsorbed Thereon For Preparing A Pharmaceutical Composition For Intranasal Administration
PL98336207A PL189918B1 (pl) 1997-04-14 1998-04-08 Zastosowanie polimerowych mikrocząstek z zaadsorbowanym na powierzchni białkiem i przeciwciałem
SK1422-99A SK282398B6 (sk) 1997-04-14 1998-04-08 Použitie mikročastíc obsahujúcich na sebe adsorbovaný proteín a protilátku na prípravu farmaceutického prostriedku na intranazálne podanie
SI9830505T SI0971703T1 (en) 1997-04-14 1998-04-08 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration
UA99116188A UA62961C2 (en) 1997-04-14 1998-08-04 Microparticles with absorbed proteins and antibodies designed for intranasal pharmaceutical composition
BG103873A BG64269B1 (bg) 1997-04-14 1999-11-10 ИЗПОЛЗВАН... НА МИКРО-А''И-И, 'ЪДЪРЖА(tm)И Б...Л'ЪК ' АД'ОРБИРАНО АН'И'ЯЛО, ЗА ПОЛ"-АВАН... НА "АРМА-...В'И-...Н 'Ъ''АВ ЗА ИН'РАНАЗАЛНО ПРИЛОЖ...НИ...
US09/988,150 US7235522B2 (en) 1997-04-14 2001-11-19 Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000856A IT1291559B1 (it) 1997-04-14 1997-04-14 Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile

Publications (2)

Publication Number Publication Date
ITMI970856A1 ITMI970856A1 (it) 1998-10-14
IT1291559B1 true IT1291559B1 (it) 1999-01-11

Family

ID=11376872

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI000856A IT1291559B1 (it) 1997-04-14 1997-04-14 Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile

Country Status (24)

Country Link
US (1) US7235522B2 (it)
EP (1) EP0971703B9 (it)
JP (1) JP2002503222A (it)
KR (1) KR100507449B1 (it)
CN (1) CN1135970C (it)
AT (1) ATE243502T1 (it)
AU (1) AU742079B2 (it)
BG (1) BG64269B1 (it)
CA (1) CA2288970C (it)
CZ (1) CZ298935B6 (it)
DE (1) DE69815828T2 (it)
DK (1) DK0971703T3 (it)
EA (1) EA002324B1 (it)
ES (1) ES2201492T3 (it)
GE (1) GEP20022646B (it)
HU (1) HU225523B1 (it)
IL (1) IL132114A (it)
IT (1) IT1291559B1 (it)
PL (1) PL189918B1 (it)
PT (1) PT971703E (it)
SK (1) SK282398B6 (it)
TR (1) TR199902536T2 (it)
UA (1) UA62961C2 (it)
WO (1) WO1998046209A1 (it)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2050425A1 (en) * 1990-09-03 1992-03-04 Yoshiaki Uda Pharmaceutical composition and its mucous use
RU2022562C1 (ru) * 1992-05-06 1994-11-15 Рубальский Олег Васильевич Способ лечения вирусной инфекции кожи и слизистых оболочек
GB9311454D0 (en) * 1993-06-03 1993-07-21 Agricultural & Food Res Pharmaceutical compositions
JP3414539B2 (ja) * 1994-05-11 2003-06-09 有限会社ドット 経鼻吸収用組成物
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced

Also Published As

Publication number Publication date
SK282398B6 (sk) 2002-01-07
US20020058069A1 (en) 2002-05-16
HU225523B1 (en) 2007-01-29
BG64269B1 (bg) 2004-08-31
CZ362499A3 (cs) 2000-04-12
EA002324B1 (ru) 2002-04-25
PL189918B1 (pl) 2005-10-31
CN1252712A (zh) 2000-05-10
UA62961C2 (en) 2004-01-15
EP0971703B9 (en) 2003-11-05
EP0971703A1 (en) 2000-01-19
DK0971703T3 (da) 2003-10-20
ES2201492T3 (es) 2004-03-16
ITMI970856A1 (it) 1998-10-14
EP0971703B1 (en) 2003-06-25
CA2288970A1 (en) 1998-10-22
CA2288970C (en) 2006-05-30
BG103873A (en) 2000-06-30
AU742079B2 (en) 2001-12-20
AU7526098A (en) 1998-11-11
DE69815828D1 (de) 2003-07-31
PT971703E (pt) 2003-11-28
EA199900934A1 (ru) 2000-04-24
HUP0001752A2 (hu) 2000-10-28
DE69815828T2 (de) 2004-05-19
TR199902536T2 (xx) 2000-02-21
PL336207A1 (en) 2000-06-05
HUP0001752A3 (en) 2001-10-29
IL132114A (en) 2004-07-25
KR100507449B1 (ko) 2005-08-10
SK142299A3 (en) 2000-09-12
JP2002503222A (ja) 2002-01-29
CN1135970C (zh) 2004-01-28
WO1998046209A1 (en) 1998-10-22
IL132114A0 (en) 2001-03-19
ATE243502T1 (de) 2003-07-15
US7235522B2 (en) 2007-06-26
GEP20022646B (en) 2002-03-25
CZ298935B6 (cs) 2008-03-12
KR20010006267A (ko) 2001-01-26

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