CA2224074C - System and method for producing drug-loaded microparticles - Google Patents

System and method for producing drug-loaded microparticles Download PDF

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Publication number
CA2224074C
CA2224074C CA002224074A CA2224074A CA2224074C CA 2224074 C CA2224074 C CA 2224074C CA 002224074 A CA002224074 A CA 002224074A CA 2224074 A CA2224074 A CA 2224074A CA 2224074 C CA2224074 C CA 2224074C
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CA
Canada
Prior art keywords
icam
drug
alginate
stream
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002224074A
Other languages
English (en)
French (fr)
Other versions
CA2224074A1 (en
Inventor
David C. Bomberger
Paul G. Catz
Mark I. Smedley
Paul C. Stearns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc filed Critical SRI International Inc
Publication of CA2224074A1 publication Critical patent/CA2224074A1/en
Application granted granted Critical
Publication of CA2224074C publication Critical patent/CA2224074C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002224074A 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles Expired - Lifetime CA2224074C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/480,624 1995-06-07
US08/480,624 US5879712A (en) 1995-06-07 1995-06-07 Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
PCT/US1996/010031 WO1996040069A1 (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Publications (2)

Publication Number Publication Date
CA2224074A1 CA2224074A1 (en) 1996-12-19
CA2224074C true CA2224074C (en) 2009-09-08

Family

ID=23908687

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224074A Expired - Lifetime CA2224074C (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Country Status (8)

Country Link
US (3) US5879712A (enExample)
EP (1) EP0833614B1 (enExample)
JP (1) JP4156665B2 (enExample)
AT (1) ATE353631T1 (enExample)
CA (1) CA2224074C (enExample)
DE (1) DE69636904T2 (enExample)
ES (1) ES2281084T3 (enExample)
WO (1) WO1996040069A1 (enExample)

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US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
ATE242001T1 (de) 1996-03-06 2003-06-15 Boehringer Ingelheim Pharma Pulverförmiges arzneimittel enthaltend interzelluläres adhäsionsmolekül
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
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US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
WO1999022768A1 (en) * 1997-10-31 1999-05-14 Monsanto Company Controlled release compositions comprising gellan gum gels
US6395298B1 (en) * 1997-10-31 2002-05-28 Pharmacia Corporation Gellan gum tablet coating
DE69817009T2 (de) * 1997-11-10 2004-06-09 Quest International B.V. Verkapseltes aktives material in einer alginatmatrix
US6485747B1 (en) * 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
US6248321B1 (en) * 1999-01-14 2001-06-19 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
DE19904785A1 (de) * 1999-02-05 2000-08-10 Ulrich Zimmermann Verfahren zur Herstellung von stabilem Alginatmaterial
US6927223B1 (en) 2000-05-26 2005-08-09 Washington State University Research Foundation Use of serotonin agents for adjunct therapy in the treatment of cancer
CN1458846A (zh) * 2000-09-08 2003-11-26 格莱风治疗公司 促红细胞生成性合成蛋白
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
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EP2075256A2 (en) 2002-01-14 2009-07-01 William Herman Multispecific binding molecules
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US20030206957A1 (en) * 2002-05-06 2003-11-06 Scherr George H. Orally administered medicament delivery systems
GB2399084B (en) * 2002-07-30 2007-01-31 Univ Liverpool Porous beads and method of production thereof
KR20050083774A (ko) 2002-10-16 2005-08-26 유로-셀티크 소시에떼 아노뉨 세포-연관된 ｃａ 125/ｏ772ｐ에 결합하는 항체들 및그것의 용도의 방법들
JP4463109B2 (ja) * 2002-11-07 2010-05-12 アドバンスド バイオニュートリション コーポレーション 栄養補助食品および水生動物の給餌方法
US20050053655A1 (en) * 2003-09-05 2005-03-10 Pharmaceutical Industry Technology And Development Center Rapid disintegrating tablets (RDTs) for pharmaceutical use and method for preparing the same
US7410978B2 (en) * 2003-11-04 2008-08-12 Supernus Pharmaceuticals, Inc. Once daily dosage forms of trospium
AU2004289222B2 (en) 2003-11-04 2010-01-21 Supernus Pharmaceuticals Inc. Compositions of quaternary ammonium containing bioavailability enhancers
US20050260258A1 (en) * 2003-12-18 2005-11-24 The Texas A&M University System Use of vitelline protein B as a microencapsulating additive
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
AR048220A1 (es) * 2005-01-28 2006-04-12 Lkm S A Lab Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido
WO2007025244A2 (en) 2005-08-25 2007-03-01 Houle Philip R Treatment systems for delivery of sensitizer solutions
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
WO2008105773A2 (en) * 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008031780A2 (de) * 2006-09-13 2008-03-20 Basf Se Verfahren zur herstellung feinteiliger dispersionen
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US20100015240A1 (en) * 2008-07-16 2010-01-21 Danielle Biggs Process for preparing microparticles containing bioactive peptides
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
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DE112016001911A5 (de) * 2015-05-21 2018-01-11 Arnold Lösler Matrixmembranschicht auf Alginatbasis
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Also Published As

Publication number Publication date
EP0833614A4 (en) 2001-07-11
US20030091649A1 (en) 2003-05-15
US5879712A (en) 1999-03-09
JPH11507382A (ja) 1999-06-29
US7087245B2 (en) 2006-08-08
CA2224074A1 (en) 1996-12-19
ATE353631T1 (de) 2007-03-15
EP0833614A1 (en) 1998-04-08
WO1996040069A1 (en) 1996-12-19
DE69636904D1 (de) 2007-03-29
JP4156665B2 (ja) 2008-09-24
US6375985B1 (en) 2002-04-23
DE69636904T2 (de) 2007-11-15
EP0833614B1 (en) 2007-02-14
ES2281084T3 (es) 2007-09-16

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